Featured Research

from universities, journals, and other organizations

NYU Chemists Use Computer Simulation To Enhance Understanding Of DNA Transcription

Date:
June 6, 2005
Source:
New York University
Summary:
New York University chemists have employed a computer simulation whose results have enhanced scientific understanding of the DNA transcription process. The study, funded by the National Institutes of Health, appears in the June 7 issue of the Proceedings of the National Academy of Sciences.

Snapshots of the nucleosomal array under different salt concentrations, which, moving left to right, show folding occurring over time.
Credit: Image courtesy of New York University

New York University chemists have employed a computer simulation whose results have enhanced scientific understanding of the DNA transcription process. The study, funded by the National Institutes of Health, appears in the June 7 issue of the Proceedings of the National Academy of Sciences.

Related Articles


Previous research has indicated that chromatin--a chromosome's substance consisting of histone proteins and DNA--exhibits salt-dependent conformations. Specifically, chains of nucleosomes, the building blocks of chromatin that appear as bead-like structures along DNA, fold into a condensed fiber as salt increases. This folding and the interplay between chromatin structures regulate fundamental gene expression. However, the molecular mechanism underlying this process remains unclear.

The research team, which included NYU chemists Tamar Schlick, Jian Sun (now at the Cornell Medical School), and Qing Zhang, analyzed a 12-nucleosome array. Using a variety of salt conditions, the researchers found that the nucleosomal array formed irregular three-dimensional zig-zag structures at high salt concentrations and "beads-on-a-string" structures at low salt, demonstrating that the structure of chromatin strongly depends on its salt environment.

To Schlick and her colleagues, these results revealed that in a low-salt environment, linker DNAs in the array were repelled, preventing array folding and resulting in a bead-like structure. However, under high-salt conditions, screening of linker DNA repulsion allows close contacts and attraction between nucleosomes, allowing the array to fold. As chromatin folding or unfolding prevents or allows the transcriptional machinery's access to the DNA in a chromosome, this computer simulation study helps to understand the mechanism of gene expression and silencing.


Story Source:

The above story is based on materials provided by New York University. Note: Materials may be edited for content and length.


Cite This Page:

New York University. "NYU Chemists Use Computer Simulation To Enhance Understanding Of DNA Transcription." ScienceDaily. ScienceDaily, 6 June 2005. <www.sciencedaily.com/releases/2005/06/050605234721.htm>.
New York University. (2005, June 6). NYU Chemists Use Computer Simulation To Enhance Understanding Of DNA Transcription. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2005/06/050605234721.htm
New York University. "NYU Chemists Use Computer Simulation To Enhance Understanding Of DNA Transcription." ScienceDaily. www.sciencedaily.com/releases/2005/06/050605234721.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Matter & Energy News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gas Production Cut on Earthquake Fears

Gas Production Cut on Earthquake Fears

Reuters - Business Video Online (Mar. 5, 2015) — The Dutch government has cut production at Europe&apos;s largest gas field in Groningen amid concerns over earthquakes which are damaging local churches. As Amy Pollock reports the decision - largely politically-motivated - could have big economic conseqeunces. Video provided by Reuters
Powered by NewsLook.com
Star Wars-Inspired Prototype Creates Holographic Display

Star Wars-Inspired Prototype Creates Holographic Display

Reuters - Innovations Video Online (Mar. 5, 2015) — A prototype holographic display named Leia - after the Star Wars princess who appeared in holographic form asking Obi-Wan Kenobu for help - is demonstrated at the Mobile World Congress in Barcelona. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
IKEA and Samsung Launch Embedded Wireless Charging Range

IKEA and Samsung Launch Embedded Wireless Charging Range

Reuters - Innovations Video Online (Mar. 5, 2015) — Samsung and IKEA hope their new embedded wireless charging products, launched at Barcelona&apos;s Mobile World Congress, will tempt consumers eager for plugless power. Jim Drury reports. Video provided by Reuters
Powered by NewsLook.com
Samsung Unveils $30,000 'Dream Doghouse'

Samsung Unveils $30,000 'Dream Doghouse'

Buzz60 (Mar. 5, 2015) — On display at the Crufts dog show in England, the &apos;dog kennel of the future&apos; comes with features like a doggie treadmill and Samsung tablet. Mike Janela (@mikejanela) has more. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins