Featured Research

from universities, journals, and other organizations

Oral Rinse Predictor Of Marrow Transplant Effectiveness, Indicates Whether Infection Will Develop

Date:
June 23, 2005
Source:
University Of Toronto
Summary:
Simple analysis of a bone marrow transplant patient's oral rinse can give medical personnel a quick indication of the transplant's effectiveness and predict whether an infection will develop, says a University of Toronto researcher.

Simple analysis of a bone marrow transplant patient's oral rinse can give medical personnel a quick indication of the transplant's effectiveness and predict whether an infection will develop, says a University of Toronto researcher. Dr. Michael Glogauer, a U of T dentistry professor with the CIHR Group in Matrix Dynamics, Dr. Yigal Dror, a professor at the U of T Faculty of Medicine and a hematologist at the Hospital for Sick Children, and dentistry doctoral candidate Chrissy Cheretakis conducted the study, which received advance online publication this month in Bone Marrow Transplantation. "This test is telling you something you can't yet see in a blood test," says Glogauer, "and we obtained the information simply by having patients rinse their mouths, which is something they'd be doing anyway to counteract the oral mucositis caused by their treatment regimen."

The researchers monitored the oral rinses of 29 pediatric bone marrow transplant patients, testing the basic sodium bicarbonate solutions for the return of neutrophils, specialized white blood cells which fight infection. Their test was able to detect the white blood cells about a week earlier than the blood test which is commonly used to confirm a successful bone marrow transplant.

The gap between the time their test showed the presence of white blood cells in the mouth and the time the cells appeared in a blood test also indicated those patients who would likely be prone to infection during their recovery. A difference of less than four days was an excellent indicator of patients who were susceptible to infection, Glogauer says.

"It shows promise as a non-invasive way to track a patient's recovery," he says. "We are using mice to study the underlying mechanisms at work here to help us better understand white blood cell recovery and function during bone marrow transplant therapy."

"Dr. Glogauer's work is an excellent example of the way in which research is unravelling the complex relationship between oral health and systemic conditions," says Dr. Cy Frank, Scientific Director of CIHR's Institute of Musculoskeletal Health and Arthritis. "We applaud Dr. Glogauer and his colleagues for the creation of new knowledge that will greatly benefit patients requiring bone marrow transplants."

The researchers are now experimenting with ways to make the test applicable at the bedside by developing a reaction that will cause the rinse to turn colour when the presence of white blood cells is detected.

###

Dr. Glogauer is a CIHR clinician scientist and the study was funded by the Hospital for Sick Children Foundation.


Story Source:

The above story is based on materials provided by University Of Toronto. Note: Materials may be edited for content and length.


Cite This Page:

University Of Toronto. "Oral Rinse Predictor Of Marrow Transplant Effectiveness, Indicates Whether Infection Will Develop." ScienceDaily. ScienceDaily, 23 June 2005. <www.sciencedaily.com/releases/2005/06/050622131257.htm>.
University Of Toronto. (2005, June 23). Oral Rinse Predictor Of Marrow Transplant Effectiveness, Indicates Whether Infection Will Develop. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2005/06/050622131257.htm
University Of Toronto. "Oral Rinse Predictor Of Marrow Transplant Effectiveness, Indicates Whether Infection Will Develop." ScienceDaily. www.sciencedaily.com/releases/2005/06/050622131257.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Cases Keep Coming for Monrovia's Island Hospital

Ebola Cases Keep Coming for Monrovia's Island Hospital

AFP (Oct. 1, 2014) A look inside Monrovia's Island Hospital, a key treatment centre in the fight against Ebola in Liberia's capital city. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Ebola Puts Stress on Liberian Health Workers

Ebola Puts Stress on Liberian Health Workers

AP (Oct. 1, 2014) The Ebola outbreak is putting stress on first responders in Liberia. Ambulance drivers say they are struggling with chronic shortages of safety equipment and patients who don't want to go to the hospital. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Newsy (Sep. 30, 2014) After the announcement that the first U.S. patient had been diagnosed with Ebola, doctors were quick to say a U.S. outbreak is highly unlikely. Video provided by Newsy
Powered by NewsLook.com
TX Hospital Confirms Patient Admitted With Ebola

TX Hospital Confirms Patient Admitted With Ebola

AP (Sep. 30, 2014) Medical officials from Texas Health Presbyterian Hospital confirm they are treating a patient with the Ebola virus, the first case found in the US. (Sept. 30 Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins