Featured Research

from universities, journals, and other organizations

Oral Rinse Predictor Of Marrow Transplant Effectiveness, Indicates Whether Infection Will Develop

Date:
June 23, 2005
Source:
University Of Toronto
Summary:
Simple analysis of a bone marrow transplant patient's oral rinse can give medical personnel a quick indication of the transplant's effectiveness and predict whether an infection will develop, says a University of Toronto researcher.

Simple analysis of a bone marrow transplant patient's oral rinse can give medical personnel a quick indication of the transplant's effectiveness and predict whether an infection will develop, says a University of Toronto researcher. Dr. Michael Glogauer, a U of T dentistry professor with the CIHR Group in Matrix Dynamics, Dr. Yigal Dror, a professor at the U of T Faculty of Medicine and a hematologist at the Hospital for Sick Children, and dentistry doctoral candidate Chrissy Cheretakis conducted the study, which received advance online publication this month in Bone Marrow Transplantation. "This test is telling you something you can't yet see in a blood test," says Glogauer, "and we obtained the information simply by having patients rinse their mouths, which is something they'd be doing anyway to counteract the oral mucositis caused by their treatment regimen."

Related Articles


The researchers monitored the oral rinses of 29 pediatric bone marrow transplant patients, testing the basic sodium bicarbonate solutions for the return of neutrophils, specialized white blood cells which fight infection. Their test was able to detect the white blood cells about a week earlier than the blood test which is commonly used to confirm a successful bone marrow transplant.

The gap between the time their test showed the presence of white blood cells in the mouth and the time the cells appeared in a blood test also indicated those patients who would likely be prone to infection during their recovery. A difference of less than four days was an excellent indicator of patients who were susceptible to infection, Glogauer says.

"It shows promise as a non-invasive way to track a patient's recovery," he says. "We are using mice to study the underlying mechanisms at work here to help us better understand white blood cell recovery and function during bone marrow transplant therapy."

"Dr. Glogauer's work is an excellent example of the way in which research is unravelling the complex relationship between oral health and systemic conditions," says Dr. Cy Frank, Scientific Director of CIHR's Institute of Musculoskeletal Health and Arthritis. "We applaud Dr. Glogauer and his colleagues for the creation of new knowledge that will greatly benefit patients requiring bone marrow transplants."

The researchers are now experimenting with ways to make the test applicable at the bedside by developing a reaction that will cause the rinse to turn colour when the presence of white blood cells is detected.

###

Dr. Glogauer is a CIHR clinician scientist and the study was funded by the Hospital for Sick Children Foundation.


Story Source:

The above story is based on materials provided by University Of Toronto. Note: Materials may be edited for content and length.


Cite This Page:

University Of Toronto. "Oral Rinse Predictor Of Marrow Transplant Effectiveness, Indicates Whether Infection Will Develop." ScienceDaily. ScienceDaily, 23 June 2005. <www.sciencedaily.com/releases/2005/06/050622131257.htm>.
University Of Toronto. (2005, June 23). Oral Rinse Predictor Of Marrow Transplant Effectiveness, Indicates Whether Infection Will Develop. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2005/06/050622131257.htm
University Of Toronto. "Oral Rinse Predictor Of Marrow Transplant Effectiveness, Indicates Whether Infection Will Develop." ScienceDaily. www.sciencedaily.com/releases/2005/06/050622131257.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins