Featured Research

from universities, journals, and other organizations

Genomic Instability And Premature Aging

Date:
July 1, 2005
Source:
Karolinska Institutet
Summary:
Premature aging syndromes often result from mutations in nuclear proteins involved in genomic integrity. Lack of an enzyme responsible for the maturation of prelamin A, also results in progeroid phenotypes in mice and humans. In Nature Medicine Online researchers at Karolinska Institutet and the University of Hong Kong describe this enzyme's importance for the stability of DNA.

Premature aging syndromes often result from mutations in nuclear proteins involved in genomic integrity. For example Hutchinson-Gilford progerial syndrome (HGPS), a severe form of early-onset premature aging, is caused by truncation in the protein lamin A. Lamin A is a nuclear protein important for chromatin attachment, DNA replication and nuclear organization. Lack of an enzyme responsible for the maturation of prelamin A, also results in progeroid phenotypes in mice and humans.

Related Articles


In Nature Medicine Online researchers at Karolinska Institutet and the University of Hong Kong describe this enzyme's importance for the stability of DNA. The results indicate that mutations in prelamin A and lamin A perturb DNA damage response and repair, resulting in genomic instability which might contribute to certain types of premature aging.

Dr Zhongjun Zhou started this research during his period as doctoral student at Karolinska Institutet. After his dissertation 2004 he has continued the research at the University of Hong Kong.

###

Publication:

Genomic instability in laminopathy-based premature agingLiu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang J, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadinanos J, Lopez-Otin C, Tse HF, Hutchinson C, Chen J, Cao Y, Cheah KSE, Tryggvason K, Zhou Z.Nature Medicine Online 26 June, 2005.


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Cite This Page:

Karolinska Institutet. "Genomic Instability And Premature Aging." ScienceDaily. ScienceDaily, 1 July 2005. <www.sciencedaily.com/releases/2005/06/050630064229.htm>.
Karolinska Institutet. (2005, July 1). Genomic Instability And Premature Aging. ScienceDaily. Retrieved March 3, 2015 from www.sciencedaily.com/releases/2005/06/050630064229.htm
Karolinska Institutet. "Genomic Instability And Premature Aging." ScienceDaily. www.sciencedaily.com/releases/2005/06/050630064229.htm (accessed March 3, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 3, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mom Triumphs Over Tragedy, Helps Other Families

Mom Triumphs Over Tragedy, Helps Other Families

AP (Mar. 3, 2015) After her son, Dax, died from a rare form of leukemia, Julie Locke decided to give back to the doctors at St. Jude Children&apos;s Research Hospital who tried to save his life. She raised $1.6M to help other patients and their families. (March 3) Video provided by AP
Powered by NewsLook.com
Looted and Leaking, South Sudan's Oil Wells Pose Health Risk

Looted and Leaking, South Sudan's Oil Wells Pose Health Risk

AFP (Mar. 3, 2015) Thick black puddles and a looted, leaking ruin are all that remain of the Thar Jath oil treatment facility, once a crucial part of South Sudan&apos;s mainstay industry. Duration: 01:13 Video provided by AFP
Powered by NewsLook.com
Woman Convicted of Poisoning Son

Woman Convicted of Poisoning Son

AP (Mar. 3, 2015) A woman who blogged for years about her son&apos;s constant health woes was convicted Monday of poisoning him to death by force-feeding heavy concentrations of sodium through his stomach tube. (March 3) Video provided by AP
Powered by NewsLook.com
Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins