Featured Research

from universities, journals, and other organizations

DNA-scanning Technology Finds Possible Sites Of Cancer Genes In Chromosomes Of Lung Cancer Cell

Date:
July 8, 2005
Source:
Dana-Farber Cancer Institute
Summary:
With equipment designed to probe the smallest segments of the genetic code, researchers at Dana-Farber Cancer Institute and collaborating institutions have found something much larger: sections of the chromosomes of lung cancer cells where cancer-related genes may lurk.

With equipment designed to probe the smallest segments of the genetic code, researchers at Dana-Farber Cancer Institute and collaborating institutions have found something much larger: sections of the chromosomes of lung cancer cells where cancer-related genes may lurk.

Related Articles


In a study in the July 1 issue of the journal Cancer Research, the researchers used single nucleotide polymorphism (SNP) array technology, which focuses on the building blocks of individual genes, to identify regions of chromosomes where genes were either left out or multiplied over and over -- mistakes that are often associated with cancer. In this effort, SNP (pronounced "snip") arrays have been used to find gene-copy errors in lung cancer cells.

"In a previous study, we showed that SNP arrays offer a unique way of locating copy-number changes in cell chromosomes and of determining when genes on a pair of chromosomes are mismatched," says the study's senior author, Matthew Meyerson, MD, PhD, of Dana-Farber. "The current study demonstrates that high-resolution SNP technology is powerful enough to identify copy-number alterations that previously hadn't been found in lung cancer cells."

Working with 70 specimens of lung cancer tissue and 31 laboratory-grown lines of lung cancer cells, the investigators used high-resolution machinery to scan the cells' chromosomes in 115,000 locations. They found several areas that had already been identified as having copy-number errors, plus five new ones -- two where genes had been deleted, and three where they had been highly over-copied.

The next step will be to identify the specific genes involved in these alterations. That, in turn, could lead to new diagnostic tests and treatments for lung cancer, by far the most common form of cancer in the United States, and one of the most difficult to treat.

There is increasing evidence that therapies aimed at specific gene abnormalities can be effective in treating cancer. Last year, for example, Meyerson and colleagues demonstrated that the drug Iressa shrank tumors in patients with the most common form of lung cancer who carry an abnormality, or mutation, in a single gene.

Meyerson points out that the presence of copy-number changes doesn't guarantee that genes in the identified regions are involved in cancer. "We'll need to characterize the genes in these regions in detail to understand their role and whether they are cancer-causing or cancer-preventing genes," he remarks.

Co-authors of the study are Barbara Weir, PhD, Thomas LaFramboise, MD, Ming Lin, Rameen Beroukhim, MD, PhD, Levi Garraway, MD, PhD, Javad Beheshti, MD, Jeffrey Lee, Pasi Janne, MD, PhD, Cheng Li, PhD, and William Sellers, MD, of Dana-Farber; Katsuhiko Naoki, MD, PhD, of Yokohama Municipal Citizen's Hospital in Yokohama, Japan; William Richards, PhD, David Sugarbaker, MD, Fei Chen, and Mark Rubin, MD, of Brigham and Women's Hospital; Luc Girard, PhD, and John Minna, MD, of the University of Texas Southwestern Medical Center in Dallas; and David Christiani, MD, of the Harvard School of Public Health.

The study was funded in part by grants from the National Institutes of Health, the National Cancer Institute, the American Cancer Society, the Flight Attendant Medical Research Institute, and the Arthur and Rochelle Belfer Foundation.

Dana-Farber Cancer Institute is a principal teaching affiliate of the Harvard Medical School and is among the leading cancer research and care centers in the United States. It is a founding member of the Dana-Farber/Harvard Cancer Center (DF/HCC), designated a comprehensive cancer center by the National Cancer Institute.


Story Source:

The above story is based on materials provided by Dana-Farber Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Dana-Farber Cancer Institute. "DNA-scanning Technology Finds Possible Sites Of Cancer Genes In Chromosomes Of Lung Cancer Cell." ScienceDaily. ScienceDaily, 8 July 2005. <www.sciencedaily.com/releases/2005/07/050708060612.htm>.
Dana-Farber Cancer Institute. (2005, July 8). DNA-scanning Technology Finds Possible Sites Of Cancer Genes In Chromosomes Of Lung Cancer Cell. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2005/07/050708060612.htm
Dana-Farber Cancer Institute. "DNA-scanning Technology Finds Possible Sites Of Cancer Genes In Chromosomes Of Lung Cancer Cell." ScienceDaily. www.sciencedaily.com/releases/2005/07/050708060612.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) — Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com
Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins