Featured Research

from universities, journals, and other organizations

Protein Amplification In Melanoma Is Possible Drug Target

Date:
July 12, 2005
Source:
Yale University
Summary:
Researchers have pinpointed specific gene and protein over-production in metastatic melanoma, pointing the way to a possible new drug target.

Researchers have pinpointed specific gene and protein over-production in metastatic melanoma, pointing the way to a possible new drug target, according to a study published in Nature July 7.

Gene amplification is a process that often happens in cancer cells when the normal DNA replication process is altered, causing many copies of the gene to be produced instead of a single copy of a region of a chromosome.

The researchers found that the MITF (microphthalmia-associated transcription factor) master regulator is the target of gene amplification in melanoma. MITF amplification also was more prevalent in metastatic disease and was correlated with decreased overall patient survival.

Collaborators at Yale, using the technology AQUA (Automated Quantitative Analysis) to quantitatively measure protein expression in melanoma tissue microarrays, also found an over-expression of the protein.

"According to the study, these data suggest that MITF represents a distinct class of 'lineage survival' or 'lineage addiction' oncogenes required for both tissue-specific development and tumor progression," said David Rimm, M.D., an author on the study and associate professor in the Department of Pathology at Yale School of Medicine.

Another Yale author on the study was Aaron Berger, a student in Rimm's laboratory. The corresponding author was William Sellers of Dana-Farber Cancer Institute in Boston. Co-authors included researchers at Brigham and Women's Hospital, Harvard, the Massachusetts Institute of Technology, Massachusetts General Hospital, and the Medical University of Vienna.

The AQUA technology is the property of HistoRx, Inc., a New Haven-based bioscience company offering novel digital technologies for in situ diagnostics developed at Yale School of Medicine. It enables researchers to localize and quantify proteins in tissue while maintaining spatial relationships--a process that was previously impossible with conventional methods of pathology analysis and which vastly increases the quality and amount of information for analysis.

###

Nature 436: 117-122 (July 7, 2005)


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Protein Amplification In Melanoma Is Possible Drug Target." ScienceDaily. ScienceDaily, 12 July 2005. <www.sciencedaily.com/releases/2005/07/050710201817.htm>.
Yale University. (2005, July 12). Protein Amplification In Melanoma Is Possible Drug Target. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2005/07/050710201817.htm
Yale University. "Protein Amplification In Melanoma Is Possible Drug Target." ScienceDaily. www.sciencedaily.com/releases/2005/07/050710201817.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins