Featured Research

from universities, journals, and other organizations

Rats' Response To 'Stop Snacking' Signal Diminished By High Fat Diet

Date:
August 2, 2005
Source:
Penn State
Summary:
Rats fed a high fat diet were less sensitive to a hormonal 'stop eating' signal than rats on a low fat diet when they were given access to a high calorie, high fat snack that the animals find yummy.

Rats fed a high fat diet were less sensitive to a hormonal 'stop eating' signal than rats on a low fat diet when they were given access to a high calorie, high fat snack that the animals find yummy.

Dr. Mihai Covasa, assistant professor of nutritional sciences and a member of the Penn State Neuroscience Institute, led the study. He says, "When we gave the rats doses of a 'stop eating' hormone, the rats on the low fat diet significantly suppressed their intake of the snack but not the rats on the high fat diet."

Covasa adds, "These results suggest that a long-term, high-fat diet may actually promote short-term overconsumption of highly palatable foods high in dietary fat by reducing sensitivity to at least one important feedback signal which would ordinarily limit eating."

The results are detailed in the current (August) issue of the Journal of Nutrition in a paper, Adaptation to a High-Fat Diet Leads to Hyperphagia and Diminished Sensitivity to Cholecystokinin in Rats. The authors are David M. Savastano, who recently earned his master's degree under Covasa's direction, and Covasa.

The 'stop eating' hormone used in the study was cholecystokinin or CCK. CCK is released by cells in the small intestine when fat or protein is present. The hormone's release activates nerves that connect the intestine with the brain where the decision to stop eating is made.

Previous studies with human subjects showed that those on a high fat diet have more CCK in their bloodstream but are less responsive to it. They typically report feeling increased hunger and declining fullness and eat more.

No human study of snacking and CCK has been reported. This study, with rats, is the first to link diminished sensitivity to CCK following exposure to a high fat diet and overconsumption of a high calorie, high fat snack.

In the current study, the rats were only given access to the high calorie, high fat snack for three hours a day. The rest of the time they received either low fat or high fat rat chow. The high and low fat chows were regulated so that they were equivalent in calories and both groups of rats gained weight at the same rate.

Even though the rats on the high fat diet ate, on average 40 percent more of the high calorie, high fat snack than the rats on the low fat diet, they didn't gain extra weight. Rats, unlike humans, cut back on their usual chow when they snack.

Covasa says, "Rats are notorious in compensating for food to maintain a constant body weight. Although adaptation to the high fat diet led to overconsumption of the high calorie, high fat snack, there was no difference in weight gain between the two groups of rats during the 20 days of testing because the rats compensated by eating less of their maintenance diet."

###

The study was supported by a PSU College of Health and Human Development research grant.


Story Source:

The above story is based on materials provided by Penn State. Note: Materials may be edited for content and length.


Cite This Page:

Penn State. "Rats' Response To 'Stop Snacking' Signal Diminished By High Fat Diet." ScienceDaily. ScienceDaily, 2 August 2005. <www.sciencedaily.com/releases/2005/08/050802061100.htm>.
Penn State. (2005, August 2). Rats' Response To 'Stop Snacking' Signal Diminished By High Fat Diet. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2005/08/050802061100.htm
Penn State. "Rats' Response To 'Stop Snacking' Signal Diminished By High Fat Diet." ScienceDaily. www.sciencedaily.com/releases/2005/08/050802061100.htm (accessed September 20, 2014).

Share This



More Mind & Brain News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Food Addiction Might Be Caused By PTSD

Food Addiction Might Be Caused By PTSD

Newsy (Sep. 18, 2014) New research shows that women who suffer from PTSD are three times more likely to develop a food addiction. Video provided by Newsy
Powered by NewsLook.com
Corporal Punishment on Decline, Debate Renews

Corporal Punishment on Decline, Debate Renews

AP (Sep. 16, 2014) Corporal punishment in the United States is on the decline, but there is renewed debate over its use after Minnesota Vikings running back Adrian Peterson was charged with child abuse. (Sept. 16) Video provided by AP
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins