Featured Research

from universities, journals, and other organizations

Researchers Discover New Tumor Defense System

Date:
August 10, 2005
Source:
American Society for Biochemistry and Molecular Biology
Summary:
Researchers have discovered that tumors release fatty acids that interfere with the cells that are trying to kill them. Consequently, strategies that reduce the amount of fatty acids surrounding the tumors may give a boost to anti-cancer therapeutics. The details of these findings appear in the September issue of the Journal of Lipid Research, an American Society for Biochemistry and Molecular Biology journal.

Bethesda, MD -- Researchers have discovered that tumors release fattyacids that interfere with the cells that are trying to kill them.Consequently, strategies that reduce the amount of fatty acidssurrounding the tumors may give a boost to anti-cancer therapeutics.The details of these findings appear in the September issue of the Journal of Lipid Research, an American Society for Biochemistry and Molecular Biology journal.

Several forms of anti-cancer therapy rely on what is known asimmunotherapeutic anti-cancer strategies, therapies that encourage thebody's natural defenses, such as cytotoxic T lymphocytes, to aid indestroying tumors. However, immunotherapeutic methods are often noteffective at removing established tumors for a number of reasonsincluding a loss of the ability of the cytotoxic T lymphocytes torecognize the tumor and a physical barrier separating the lymphocytesand the tumor.

Now, Dr. Alan M. Kleinfeld and Clifford Okada of the TorreyPines Institute for Molecular Studies in San Diego, CA, have addedanother reason to this list. They discovered that tumors secrete fattyacids which inhibit the cytotoxic T lymphocytes' ability to kill tumorcells.

"We found two things," explains Dr. Kleinfeld. "First, the mostcommon type of free fatty acids, which at normal levels are essentialfor life, at high levels prevents the cytotoxic T lymphocytes fromdestroying tumor cells. The second thing is that human breast cancercells, but not normal tissue from the same breast, produce very largeamounts of the type of free fatty acids that block the cytotoxic Tlymphocytes. Thus the cancer may have a way of defending itself againstattack by the immune system, thereby reducing the potential efficacy ofnovel anti cancer therapies that rely on a functioning immune system."

The free fatty acids act against cytotoxic T lymphocytes byblocking a number of the lymphocytes' signaling events. For example,they keep certain proteins from being phosphorylated and they alsoprevent an increase in intracellular calcium that is essential for thecytotoxic T lymphocytes to kill the tumor cells. Dr. Kleinfeld suspectsthat these signaling events are being blocked at the cells' membranes.

These results from the Torrey Pines Institute for MolecularStudies raise the possibilities of new therapeutic targets for cancer,such as those that may transport free fatty acids out of the tumor.Alternatively, free fatty acid levels in the blood could be used tohelp gauge the aggressive potential of a tumor.

###

The American Society for Biochemistry and Molecular Biology (ASBMB)is a nonprofit scientific and educational organization with over 11,000members in the United States and internationally. Most members teachand conduct research at colleges and universities. Others conductresearch in various government laboratories, nonprofit researchinstitutions, and industry.

Founded in 1906, the Society is based in Bethesda, Maryland, onthe campus of the Federation of American Societies for ExperimentalBiology. The Society's primary purpose is to advance the sciences ofbiochemistry and molecular biology through its publications, theJournal of Biological Chemistry, the Journal of Lipid Research,Molecular and Cellular Proteomics, and Biochemistry and MolecularBiology Education, and the holding of scientific meetings.

For more information about ASBMB, see the Society's website at www.asbmb.org.

The manuscript for the Journal of Lipid Research paper can be downloaded from the following URL:http://www.jlr.org/cgi/content/abstract/M500151-JLR200


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Biochemistry and Molecular Biology. "Researchers Discover New Tumor Defense System." ScienceDaily. ScienceDaily, 10 August 2005. <www.sciencedaily.com/releases/2005/08/050810134419.htm>.
American Society for Biochemistry and Molecular Biology. (2005, August 10). Researchers Discover New Tumor Defense System. ScienceDaily. Retrieved September 19, 2014 from www.sciencedaily.com/releases/2005/08/050810134419.htm
American Society for Biochemistry and Molecular Biology. "Researchers Discover New Tumor Defense System." ScienceDaily. www.sciencedaily.com/releases/2005/08/050810134419.htm (accessed September 19, 2014).

Share This



More Health & Medicine News

Friday, September 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com
What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
U.S. Food Makers Surpass Calorie-Cutting Pledge

U.S. Food Makers Surpass Calorie-Cutting Pledge

Newsy (Sep. 18, 2014) Sixteen large food and beverage companies in the United States that committed to cut calories in their products far surpassed their target. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins