Featured Research

from universities, journals, and other organizations

Immune System Discovery Offers Hope For Cancer, AIDS Patients

Date:
August 15, 2005
Source:
Research Australia
Summary:
Monash University scientists have rejuvenated the immune systems of mice and humans using a common hormone.

Monash University scientists have rejuvenated the immune systems of mice and humans using a common hormone.

Related Articles


The scientists, led by Associate Professor Richard Boyd and Dr JayneSutherland from the Monash Immunology and Stem Cell Laboratories, haverevitalised the thymus which produces the T cells required to fightinfection but which shuts down from early adulthood.

Their achievement, published in the August issue of the Journalof Immunology, has offered new hope for patients with cancer, AIDS andother immunodeficiencies and for transplant patients.

The Monash study showed inhibiting sex steroids through theLeuteinizing Hormone-Releasing Hormone could help regrow the thymus,increase output of new T cells, enhance T cell responses and improverecovery following bone marrow transplants. It also showed, for thefirst time, that prostate cancer patients who had their sex steroidstemporarily blocked had increased levels of new T cells in their blood.

The researchers found inhibiting sex steroids improved theproduction of haemopoietic stem cells in bone marrow. These cellsprovide 'fuel' for the bone marrow and thymus to produce blood cells.

Associate Professor Boyd said the immune system deterioratedseverely with age, and was further destroyed by severe viral infectionand common cancer treatments such as chemotherapy and radiotherapy.

"The resulting immunodeficiency can allow cancer relapse andleave patients at greater risk of infections which are often fatal," hesaid. "The ability to overcome these immune system deficienciesprovides a completely new approach to treating cancer and may work inmany other severe clinical conditions such as HIV/AIDS. It may alsoboost the effectiveness of vaccines to cancer and infections."

Because the scientists have been able to manipulate the way thethymus grows back, they believe they should be able to rebuild theimmune system of patients who are receiving transplants so donormaterial is not rejected.

The group has initiated pre-clinical trials using thistechnology to induce immune tolerance to organ transplants. The trials,led by clinical immunologist Dr David Sachs, are being undertaken atthe Massachusetts General Hospital, the largest teaching affiliate ofHarvard Medical School.

The technology, licensed to Norwood Immunology, is also aboutto be used in clinical trials in leading US cancer centres on patientsreceiving chemotherapy and haemopoietic stem cell transplants.



Story Source:

The above story is based on materials provided by Research Australia. Note: Materials may be edited for content and length.


Cite This Page:

Research Australia. "Immune System Discovery Offers Hope For Cancer, AIDS Patients." ScienceDaily. ScienceDaily, 15 August 2005. <www.sciencedaily.com/releases/2005/08/050810135027.htm>.
Research Australia. (2005, August 15). Immune System Discovery Offers Hope For Cancer, AIDS Patients. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2005/08/050810135027.htm
Research Australia. "Immune System Discovery Offers Hope For Cancer, AIDS Patients." ScienceDaily. www.sciencedaily.com/releases/2005/08/050810135027.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins