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Penn Researchers Discover Key To How SARS Virus Infects Cells

Date:
August 16, 2005
Source:
University of Pennsylvania School of Medicine
Summary:
Researchers from the University of Pennsylvania School of Medicine have found that inhibitors of an enzyme called cathepsin L prevent the SARS (severe acute respiratory syndrome) virus from entering target cells. This study also demonstrates a new mechanism for how viral proteins are activated within host cells.

A proposed model of how SARS coronavirus enters the host cell. To gain entry, the virus binds to receptors on the cell surface as is taken up into a vesicle (endocytosis). Cathepsin L proteases facilitate fusion of the viral membrane and the vesicle membrane. Credit: Graham Simmons, PhD and Paul Bates, PhD (University of Pennsylvania School of Medicine)

Researchers from the University of Pennsylvania School of Medicine have found that inhibitors of an enzyme called cathepsin L prevent the SARS (severe acute respiratory syndrome) virus from entering target cells. SARS is caused by an emergent coronavirus. There is no effective treatment at this time.


Story Source:

The above story is based on materials provided by University of Pennsylvania School of Medicine. Note: Materials may be edited for content and length.


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University of Pennsylvania School of Medicine. "Penn Researchers Discover Key To How SARS Virus Infects Cells." ScienceDaily. ScienceDaily, 16 August 2005. <www.sciencedaily.com/releases/2005/08/050814171056.htm>.
University of Pennsylvania School of Medicine. (2005, August 16). Penn Researchers Discover Key To How SARS Virus Infects Cells. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2005/08/050814171056.htm
University of Pennsylvania School of Medicine. "Penn Researchers Discover Key To How SARS Virus Infects Cells." ScienceDaily. www.sciencedaily.com/releases/2005/08/050814171056.htm (accessed April 18, 2014).

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