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Boosting The BCG Vaccine To Beat Tuberculosis

Date:
August 20, 2005
Source:
Journal of Clinical Investigation
Summary:
In a new JCI study scientists describe a novel vaccine strain with high efficacy against tuberculosis. The new BCG vaccine strain protects mice against tuberculosis significantly better than the parental BCG. Superior protection is not only induced against the laboratory strain of M. tuberculosis but also against a clinical isolate of the Beijing/W family, a straing of tuberculosis that is spreading all over the world, is drug-resistant, and is responsible for the most threatening disease outbreaks.

Tuberculosis remains a major global health threat. Although more than 3 billion doses of the BCG vaccine have been administered to fight tuberculosis, the ability of the BCG vaccine to protect adults is very limited, as is its efficacy against newly emerging isolates.

In a study appearing online on August 18 in advance of print publication of the September 1 issue of the Journal of Clinical Investigation, Stefan Kaufmann and colleagues from the Max Planck Institute devise a strategy to boost the immunogenicity of BCG and describe a novel vaccine strain with high efficacy against tuberculosis. The researchers engineer a BCG strain that secretes the listeriolysin protein, which punches holes in the membranes of phagosomes where M. tuberculosis is located, allowing better T cell-mediated immunity. Because listeriolysin works optimally at a pH of 5.8, the researchers also deleted the urease C gene of BCG, which normally plays a role in pH neutralization of the phagosome. The lack of urease C allows phagosomal acidification and provides an ideal pH environment for listeriolysin.

The new BCG vaccine strain protects mice against tuberculosis significantly better than the parental BCG. Superior protection is not only induced against the laboratory strain of M. tuberculosis but also against a clinical isolate of the Beijing/W family, a straing of tuberculosis that is spreading all over the world, is drug-resistant, and is responsible for the most threatening disease outbreaks.

###

TITLE: Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guιrin mutants that secrete listeriolysin

View the PDF of this article at: https://www.the-jci.org/article.php?id=24617


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Boosting The BCG Vaccine To Beat Tuberculosis." ScienceDaily. ScienceDaily, 20 August 2005. <www.sciencedaily.com/releases/2005/08/050819133159.htm>.
Journal of Clinical Investigation. (2005, August 20). Boosting The BCG Vaccine To Beat Tuberculosis. ScienceDaily. Retrieved April 25, 2014 from www.sciencedaily.com/releases/2005/08/050819133159.htm
Journal of Clinical Investigation. "Boosting The BCG Vaccine To Beat Tuberculosis." ScienceDaily. www.sciencedaily.com/releases/2005/08/050819133159.htm (accessed April 25, 2014).

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