Featured Research

from universities, journals, and other organizations

Boosting The BCG Vaccine To Beat Tuberculosis

Date:
August 20, 2005
Source:
Journal of Clinical Investigation
Summary:
In a new JCI study scientists describe a novel vaccine strain with high efficacy against tuberculosis. The new BCG vaccine strain protects mice against tuberculosis significantly better than the parental BCG. Superior protection is not only induced against the laboratory strain of M. tuberculosis but also against a clinical isolate of the Beijing/W family, a straing of tuberculosis that is spreading all over the world, is drug-resistant, and is responsible for the most threatening disease outbreaks.

Tuberculosis remains a major global health threat. Although morethan 3 billion doses of the BCG vaccine have been administered to fighttuberculosis, the ability of the BCG vaccine to protect adults is verylimited, as is its efficacy against newly emerging isolates.

In a study appearing online on August 18 in advance of print publication of the September 1 issue of the Journal of Clinical Investigation,Stefan Kaufmann and colleagues from the Max Planck Institute devise astrategy to boost the immunogenicity of BCG and describe a novelvaccine strain with high efficacy against tuberculosis. The researchersengineer a BCG strain that secretes the listeriolysin protein, whichpunches holes in the membranes of phagosomes where M. tuberculosis islocated, allowing better T cell-mediated immunity. Becauselisteriolysin works optimally at a pH of 5.8, the researchers alsodeleted the urease C gene of BCG, which normally plays a role in pHneutralization of the phagosome. The lack of urease C allows phagosomalacidification and provides an ideal pH environment for listeriolysin.

The new BCG vaccine strain protects mice against tuberculosissignificantly better than the parental BCG. Superior protection is notonly induced against the laboratory strain of M. tuberculosis but alsoagainst a clinical isolate of the Beijing/W family, a straing oftuberculosis that is spreading all over the world, is drug-resistant,and is responsible for the most threatening disease outbreaks.

###

TITLE: Increased vaccine efficacy against tuberculosis ofrecombinant Mycobacterium bovis bacille Calmette-Guιrin mutants thatsecrete listeriolysin

View the PDF of this article at: https://www.the-jci.org/article.php?id=24617


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Boosting The BCG Vaccine To Beat Tuberculosis." ScienceDaily. ScienceDaily, 20 August 2005. <www.sciencedaily.com/releases/2005/08/050819133159.htm>.
Journal of Clinical Investigation. (2005, August 20). Boosting The BCG Vaccine To Beat Tuberculosis. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2005/08/050819133159.htm
Journal of Clinical Investigation. "Boosting The BCG Vaccine To Beat Tuberculosis." ScienceDaily. www.sciencedaily.com/releases/2005/08/050819133159.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) — Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) — The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) — Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) — New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins