Featured Research

from universities, journals, and other organizations

Boosting The BCG Vaccine To Beat Tuberculosis

Date:
August 20, 2005
Source:
Journal of Clinical Investigation
Summary:
In a new JCI study scientists describe a novel vaccine strain with high efficacy against tuberculosis. The new BCG vaccine strain protects mice against tuberculosis significantly better than the parental BCG. Superior protection is not only induced against the laboratory strain of M. tuberculosis but also against a clinical isolate of the Beijing/W family, a straing of tuberculosis that is spreading all over the world, is drug-resistant, and is responsible for the most threatening disease outbreaks.

Tuberculosis remains a major global health threat. Although morethan 3 billion doses of the BCG vaccine have been administered to fighttuberculosis, the ability of the BCG vaccine to protect adults is verylimited, as is its efficacy against newly emerging isolates.

In a study appearing online on August 18 in advance of print publication of the September 1 issue of the Journal of Clinical Investigation,Stefan Kaufmann and colleagues from the Max Planck Institute devise astrategy to boost the immunogenicity of BCG and describe a novelvaccine strain with high efficacy against tuberculosis. The researchersengineer a BCG strain that secretes the listeriolysin protein, whichpunches holes in the membranes of phagosomes where M. tuberculosis islocated, allowing better T cell-mediated immunity. Becauselisteriolysin works optimally at a pH of 5.8, the researchers alsodeleted the urease C gene of BCG, which normally plays a role in pHneutralization of the phagosome. The lack of urease C allows phagosomalacidification and provides an ideal pH environment for listeriolysin.

The new BCG vaccine strain protects mice against tuberculosissignificantly better than the parental BCG. Superior protection is notonly induced against the laboratory strain of M. tuberculosis but alsoagainst a clinical isolate of the Beijing/W family, a straing oftuberculosis that is spreading all over the world, is drug-resistant,and is responsible for the most threatening disease outbreaks.

###

TITLE: Increased vaccine efficacy against tuberculosis ofrecombinant Mycobacterium bovis bacille Calmette-Guιrin mutants thatsecrete listeriolysin

View the PDF of this article at: https://www.the-jci.org/article.php?id=24617


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Boosting The BCG Vaccine To Beat Tuberculosis." ScienceDaily. ScienceDaily, 20 August 2005. <www.sciencedaily.com/releases/2005/08/050819133159.htm>.
Journal of Clinical Investigation. (2005, August 20). Boosting The BCG Vaccine To Beat Tuberculosis. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2005/08/050819133159.htm
Journal of Clinical Investigation. "Boosting The BCG Vaccine To Beat Tuberculosis." ScienceDaily. www.sciencedaily.com/releases/2005/08/050819133159.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) — Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) — At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) — The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:  

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile iPhone Android Web
      Follow Facebook Twitter Google+
      Subscribe RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins