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Penn Study Finds A New Role For RNA In Human Immune Response

Date:
August 24, 2005
Source:
University of Pennsylvania School of Medicine
Summary:
Researchers at the University of Pennsylvania School of Medicine have published the first study to test the role of RNA chemical modifications on immunity. They have demonstrated that RNA from bacteria stimulates immune cells to orchestrate destruction of invading pathogens. The authors concluded that the potential of RNA to activate immunity seems to be inversely correlated with the extent of its chemical modification.

Philadelphia, PA - Researchers at the University of Pennsylvania School of Medicine have published the first study to test the role of RNA chemical modifications on immunity. They have demonstrated that RNA from bacteria stimulates immune cells to orchestrate destruction of invading pathogens. Most RNA from human cells is recognized as being self and does not stimulate an immune response to the same extent as invading bacteria or viruses. The researchers hypothesize that if this self-recognition fails, then autoimmune diseases such as systemic lupus erythematosus could result.


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The above story is based on materials provided by University of Pennsylvania School of Medicine. Note: Materials may be edited for content and length.


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University of Pennsylvania School of Medicine. "Penn Study Finds A New Role For RNA In Human Immune Response." ScienceDaily. ScienceDaily, 24 August 2005. <www.sciencedaily.com/releases/2005/08/050824082351.htm>.
University of Pennsylvania School of Medicine. (2005, August 24). Penn Study Finds A New Role For RNA In Human Immune Response. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2005/08/050824082351.htm
University of Pennsylvania School of Medicine. "Penn Study Finds A New Role For RNA In Human Immune Response." ScienceDaily. www.sciencedaily.com/releases/2005/08/050824082351.htm (accessed April 18, 2014).

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