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New Dye Could Offer Early Test For Alzheimer's; MIT Technique Is Noninvasive

Date:
August 26, 2005
Source:
Massachusetts Institute of Technology
Summary:
MIT scientists have developed a new dye that could offer noninvasive early diagnosis of Alzheimer's disease, a discovery that could aid in monitoring the progression of the disease and in studying the efficacy of new treatments to stop it. The new dye, called NIAD-4, was developed through a targeted design process based on a set of specific requirements, including the ability to enter the brain rapidly upon injection, bind to amyloid plaques, absorb and fluoresce radiation in the right spectral range, and provide sharp contrast between the plaques and the surrounding tissue.

MIT scientists have found a new way to monitor Alzheimer's disease using a fluorescent marker (“bubbles” in the background). The dye enters the brain after an intravenous injection and selectively binds to the plaques associated with the disease. Subsequent scanning with a near-infrared laser beam (hv) makes it possible to monitor the plaques through the characteristic fluorescence of the dye (black circle).
Credit: Image courtesy of Evgueni Nesterov

CAMBRIDGE, Mass.--MIT scientists have developed a new dye that could offer noninvasive early diagnosis of Alzheimer's disease, a discovery that could aid in monitoring the progression of the disease and in studying the efficacy of new treatments to stop it.


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The above story is based on materials provided by Massachusetts Institute of Technology. Note: Materials may be edited for content and length.


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Massachusetts Institute of Technology. "New Dye Could Offer Early Test For Alzheimer's; MIT Technique Is Noninvasive." ScienceDaily. ScienceDaily, 26 August 2005. <www.sciencedaily.com/releases/2005/08/050826075318.htm>.
Massachusetts Institute of Technology. (2005, August 26). New Dye Could Offer Early Test For Alzheimer's; MIT Technique Is Noninvasive. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2005/08/050826075318.htm
Massachusetts Institute of Technology. "New Dye Could Offer Early Test For Alzheimer's; MIT Technique Is Noninvasive." ScienceDaily. www.sciencedaily.com/releases/2005/08/050826075318.htm (accessed April 20, 2014).

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