Featured Research

from universities, journals, and other organizations

Oral Contraceptive Effective In Controlling Premenstrual Disorder

Date:
August 31, 2005
Source:
Yale University
Summary:
A new study led by researchers at Yale School of Medicine shows for the first time that a low dose oral contraceptive is effective in treating symptoms of premenstrual dysphoric disorder (PMDD), the most severe form of premenstrual syndrome.

New Haven, Conn.-A new study led by researchers at Yale School ofMedicine shows for the first time that a low dose oral contraceptivewith a unique progestin and dosing regimen is effective in treatingsymptoms of premenstrual dysphoric disorder (PMDD), the most severeform of premenstrual syndrome.

Related Articles


PMDD is characterized by cyclical mood, behavioral and physicalsymptoms that can be debilitating in some women. The cause of PMDD isunknown, "although it is clear that changes in steroid hormone levelsconstitute a trigger for symptom production," said Kimberly Yonkers,M.D., associate professor in the Departments of Psychiatry andEpidemiology and Public Health and lead author of the study. She saidsymptoms are diminished by suppressing ovarian activity and can beprovoked by hormones given to women who are no longer menstruating.

The multi-center, double-blind, randomized clinical trial included 450women ages 18 to 40 from 64 medical centers across the country withsymptoms of PMDD and who were given either the oral contraceptive or aplacebo. Women who were given the oral contraceptive had significantlygreater improvement (48.4 percent compared to 36.1 percent of women onplacebo) in productivity, enjoyment of hobbies, social activities, andinterpersonal relationships, and experienced greater symptom reduction.Forty-four women from both groups withdrew from the study due toadverse effects such as nausea and intermenstrual bleeding.

The low dose oral contraceptive contains drospirenone, a new progestin,and ethinyl estradiol. It was administered for 24 days followed by fourdays of inactive pills, which is different than traditional dosingregimens that have a regimen of seven days of inactive pills. The newregimen is designed for greater ovarian suppression and a more stablehormonal environment. The women were evaluated over the course of twomenstrual cycles.

Yonkers said the results show the contraceptive is roughly as effectiveas serotonin reuptake inhibitors (SSRIs), which are commonly used asanti-depressants. "It's not necessarily better, but for women who areseeking contraception in addition to control of PMDD, this would bemore efficient because they could take one treatment," she said.

###

Obstetrics & Gynecology 106: 492-503 (September 2005)


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Oral Contraceptive Effective In Controlling Premenstrual Disorder." ScienceDaily. ScienceDaily, 31 August 2005. <www.sciencedaily.com/releases/2005/08/050831071714.htm>.
Yale University. (2005, August 31). Oral Contraceptive Effective In Controlling Premenstrual Disorder. ScienceDaily. Retrieved February 1, 2015 from www.sciencedaily.com/releases/2005/08/050831071714.htm
Yale University. "Oral Contraceptive Effective In Controlling Premenstrual Disorder." ScienceDaily. www.sciencedaily.com/releases/2005/08/050831071714.htm (accessed February 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, February 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) — The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) — President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) — The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) — The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins