Featured Research

from universities, journals, and other organizations

Oral Contraceptive Effective In Controlling Premenstrual Disorder

Date:
August 31, 2005
Source:
Yale University
Summary:
A new study led by researchers at Yale School of Medicine shows for the first time that a low dose oral contraceptive is effective in treating symptoms of premenstrual dysphoric disorder (PMDD), the most severe form of premenstrual syndrome.

New Haven, Conn.-A new study led by researchers at Yale School of Medicine shows for the first time that a low dose oral contraceptive with a unique progestin and dosing regimen is effective in treating symptoms of premenstrual dysphoric disorder (PMDD), the most severe form of premenstrual syndrome.

PMDD is characterized by cyclical mood, behavioral and physical symptoms that can be debilitating in some women. The cause of PMDD is unknown, "although it is clear that changes in steroid hormone levels constitute a trigger for symptom production," said Kimberly Yonkers, M.D., associate professor in the Departments of Psychiatry and Epidemiology and Public Health and lead author of the study. She said symptoms are diminished by suppressing ovarian activity and can be provoked by hormones given to women who are no longer menstruating.

The multi-center, double-blind, randomized clinical trial included 450 women ages 18 to 40 from 64 medical centers across the country with symptoms of PMDD and who were given either the oral contraceptive or a placebo. Women who were given the oral contraceptive had significantly greater improvement (48.4 percent compared to 36.1 percent of women on placebo) in productivity, enjoyment of hobbies, social activities, and interpersonal relationships, and experienced greater symptom reduction. Forty-four women from both groups withdrew from the study due to adverse effects such as nausea and intermenstrual bleeding.

The low dose oral contraceptive contains drospirenone, a new progestin, and ethinyl estradiol. It was administered for 24 days followed by four days of inactive pills, which is different than traditional dosing regimens that have a regimen of seven days of inactive pills. The new regimen is designed for greater ovarian suppression and a more stable hormonal environment. The women were evaluated over the course of two menstrual cycles.

Yonkers said the results show the contraceptive is roughly as effective as serotonin reuptake inhibitors (SSRIs), which are commonly used as anti-depressants. "It's not necessarily better, but for women who are seeking contraception in addition to control of PMDD, this would be more efficient because they could take one treatment," she said.

###

Obstetrics & Gynecology 106: 492-503 (September 2005)


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Oral Contraceptive Effective In Controlling Premenstrual Disorder." ScienceDaily. ScienceDaily, 31 August 2005. <www.sciencedaily.com/releases/2005/08/050831071714.htm>.
Yale University. (2005, August 31). Oral Contraceptive Effective In Controlling Premenstrual Disorder. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2005/08/050831071714.htm
Yale University. "Oral Contraceptive Effective In Controlling Premenstrual Disorder." ScienceDaily. www.sciencedaily.com/releases/2005/08/050831071714.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) — Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) — A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) — Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) — NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins