Featured Research

from universities, journals, and other organizations

Losing Sleep Over Heartburn? Treating Nighttime Heartburn Improves Sleep And Boosts Quality Of Life

Date:
September 3, 2005
Source:
Blackwell Publishing Ltd.
Summary:
The first major multi-center, randomized, double-blind, placebo-controlled trial addressing therapy for gastroesophageal reflux disease (GERD) related sleep disorders is published in the September issue of The American Journal of Gastroenterology.

Bethesda, MD, September 1, 2005 -- The first major multi-center,randomized, double-blind, placebo-controlled trial addressing therapyfor gastroesophageal reflux disease (GERD) related sleep disorders ispublished in the September issue of The American Journal ofGastroenterology. This study demonstrated that effective acidsuppression therapy with a proton pump inhibitor (PPI), either 20 mgsor 40 mgs of esomeprazole, relieved nighttime heartburn symptoms andGERD-related sleep disturbances, which significantly improved sleepquality and thereby improved work productivity.

The researchers found that nighttime heartburn was relieved in 53.1percent, 50.5 percent and 12.7 percent of patients who receivedesomeprazole 40 mg, esomeprazole 20 mg and placebo, respectively.Additionally, GERD-related sleep disturbances resolved in significantlymore patients who received therapy than those who received placebo. Thehigh percentage of patients with resolutions of sleep disturbances inthe current trial was both statistically and clinically significant.

"Sleep problems are extremely common in patients with GERD and areoften unrecognized," said lead author David A. Johnson, M.D., FACG,Professor of Medicine and Chief of Gastroenterology at Eastern VirginiaMedical School who serves as the Vice President of the American Collegeof Gastroenterology. For those with frequent and moderate-to-severesymptoms, GERD has a significant negative impact on sleep. "Anyonewho's had a poor night's rest knows how much that impacts theirperformance the next day. We found that nighttime heartburn is atreatable condition that responds to effective, acid-suppressivemedical therapy such as esomeprazole."

Additionally, an estimate by the American College of Gastroenterologybased on findings from this study reveals that U.S. workers whofrequently suffer from moderate-to-severe nighttime heartburn symptomscost the U.S. economy $1,920,528,315 per week in paid hours of lostproductivity.

According to Dr. Johnson, "Physicians treating patients with acidreflux therefore need to ask about sleep problems and furthermore toask how patients feel when they wake up the next day. Daytime fatigue,irritability, concentration problems may all suggest a problem withrestful sleep. Appropriate recognition of this will lead to appropriatetherapy." He continued, "Sleep quality should be included as animportant goal for optimal disease management of GERD. Even more so ina time of emphasis on quality management and achieving the bestoutcomes in medical care, this study demonstrates that appropriatetreatment for GERD is an investment which has profound quality benefitsfor patients and economic benefits for employers."

According to the American College of Gastroenterology, approximately 20percent of U.S. adults suffer from weekly heartburn symptoms. The ACG,using data from a Gallup poll, estimates that 79 percent of heartburnsufferers have nighttime symptoms, of whom 50 percent have symptomsthat are moderate to severe.

###

Full-text of the Johnson study can be accessed through the American Journal of Gastroenterology athttp://www.blackwell-synergy.com/doi/full/10.1111/j.1572-0241.2005.00285.x

Visit the American Journal of Gastroenterology Web site at www.blackwellpublishing.com/ajg.



Story Source:

The above story is based on materials provided by Blackwell Publishing Ltd.. Note: Materials may be edited for content and length.


Cite This Page:

Blackwell Publishing Ltd.. "Losing Sleep Over Heartburn? Treating Nighttime Heartburn Improves Sleep And Boosts Quality Of Life." ScienceDaily. ScienceDaily, 3 September 2005. <www.sciencedaily.com/releases/2005/09/050902071653.htm>.
Blackwell Publishing Ltd.. (2005, September 3). Losing Sleep Over Heartburn? Treating Nighttime Heartburn Improves Sleep And Boosts Quality Of Life. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2005/09/050902071653.htm
Blackwell Publishing Ltd.. "Losing Sleep Over Heartburn? Treating Nighttime Heartburn Improves Sleep And Boosts Quality Of Life." ScienceDaily. www.sciencedaily.com/releases/2005/09/050902071653.htm (accessed August 29, 2014).

Share This




More Mind & Brain News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill 'trips' May Reduce Falls for Elderly

Treadmill 'trips' May Reduce Falls for Elderly

AP (Aug. 28, 2014) Scientists are tripping the elderly on purpose in a Chicago lab in an effort to better prevent seniors from falling and injuring themselves in real life. (Aug.28) Video provided by AP
Powered by NewsLook.com
Alice in Wonderland Syndrome

Alice in Wonderland Syndrome

Ivanhoe (Aug. 27, 2014) It’s an unusual condition with a colorful name. Kids with “Alice in Wonderland” syndrome see sudden distortions in objects they’re looking at or their own bodies appear to change size, a lot like the main character in the Lewis Carroll story. Video provided by Ivanhoe
Powered by NewsLook.com
Stopping Schizophrenia Before Birth

Stopping Schizophrenia Before Birth

Ivanhoe (Aug. 27, 2014) Scientists have long called choline a “brain booster” essential for human development. Not only does it aid in memory and learning, researchers now believe choline could help prevent mental illness. Video provided by Ivanhoe
Powered by NewsLook.com
Personalized Brain Vaccine for Glioblastoma

Personalized Brain Vaccine for Glioblastoma

Ivanhoe (Aug. 27, 2014) Glioblastoma is the most common and aggressive brain cancer in humans. Now a new treatment using the patient’s own tumor could help slow down its progression and help patients live longer. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins