Featured Research

from universities, journals, and other organizations

A New Player In The Battle Against Hepatitis Prevents Inflammation And The Death Of Liver Cells

Date:
September 5, 2005
Source:
VIB, Flanders Interuniversity Institute of Biotechnology
Summary:
Scientists from the Flanders Interuniversity Institute for Biotechnology (VIB) have again achieved a breakthrough in research on hepatitis. The researchers, connected to Ghent University, have discovered the function of one of the most important proteins involved in hepatitis. Using a mouse model, they have shown that the protein prevents inflammation of the liver as well as the death of liver cells. This discovery can form the basis for the development of a new therapy in the battle against hepatitis in humans.

Hepatitis, a liver disorder

Hepatitis is a collective term for a number of inflammations of the liver whose symptoms strongly resemble each other. These inflammations can have a wide variety of causes, such as alcohol abuse or infection by a hepatitis virus. Hepatitis B and C, for example, are caused by a virus through contact with the blood or other bodily fluids of infected persons. In some cases, the person remains a carrier of the virus, and chronic hepatitis and even cancer of the liver can develop.

In Belgium, at least 700,000 people have had hepatitis B, and 5%-10% of these persons are still chronic carriers of the virus. Each year, there are about 6000 new infections. The number of people with hepatitis C comes to 80,000-100,000 - and 60%-80% of these persons develop chronic hepatitis. There is a vaccination against hepatitis B, but none against hepatitis C.

A new role for the protein ABIN-1

TNF (Tumor Necrosis Factor) is produced by our body, normally in small quantities. In inflammations of the liver, excessive TNF production activates the mechanisms that lead to inflammation and the death of liver cells and liver tissue. In addition, excessive TNF in liver cells stimulates the protein NF-ƒkB, which is also responsible for the inflammation of the liver. This makes NF-ƒkB an attractive target for a therapy that would neutralize the inflammation. However, an ideal therapy also needs to prevent the death of the liver cells.

The new player that this research brings a step closer to the realization of such a therapy is the protein ABIN-1. From previous research by the VIB research group - led by Rudi Beyaert - it turns out that ABIN-1 inhibits the action of NF-ƒkB. Now, Andy Wullaert and several colleagues from this team have shown that an extra dose of ABIN-1 provides a double protection to liver cells in mice. With an elevated production of ABIN-1, this protein will neutralize the inflammation caused by NF-ƒkB and also prevent the complete death of liver cells after induction by TNF.

ABIN-1 in the treatment of liver disorders

This research discloses the double protective action of ABIN-1 in liver disorders. NF-ƒkB, also responsible for inflammations, is inhibited by an elevated presence of ABIN-1. In addition, ABIN-1 also counteracts the death of liver cells. Further research can lead to new therapies in the battle against hepatitis, through which - by increasing the presence of ABIN-1 in the liver - one can inhibit the inflammation and prevent dell death.


Story Source:

The above story is based on materials provided by VIB, Flanders Interuniversity Institute of Biotechnology. Note: Materials may be edited for content and length.


Cite This Page:

VIB, Flanders Interuniversity Institute of Biotechnology. "A New Player In The Battle Against Hepatitis Prevents Inflammation And The Death Of Liver Cells." ScienceDaily. ScienceDaily, 5 September 2005. <www.sciencedaily.com/releases/2005/09/050904230438.htm>.
VIB, Flanders Interuniversity Institute of Biotechnology. (2005, September 5). A New Player In The Battle Against Hepatitis Prevents Inflammation And The Death Of Liver Cells. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2005/09/050904230438.htm
VIB, Flanders Interuniversity Institute of Biotechnology. "A New Player In The Battle Against Hepatitis Prevents Inflammation And The Death Of Liver Cells." ScienceDaily. www.sciencedaily.com/releases/2005/09/050904230438.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com
Catching More Than Fish: Ugandan Town Crippled by AIDS

Catching More Than Fish: Ugandan Town Crippled by AIDS

AFP (Apr. 22, 2014) The village of Kasensero on the shores of Lake Victoria was where HIV-AIDS was first discovered in Uganda. Its transient population of fishermen and sex workers means the nationwide programme to combat the virus has had little impact. Duration: 02:30 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins