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Fatty Acids: Good For The Brain, Good For Alzheimer Disease

Date:
September 11, 2005
Source:
Journal of Clinical Investigation
Summary:
A number of studies suggest a protective action of the fatty acid DHA in cognitive decline and in Alzheimer disease (AD). However, the molecular mechanism is not understood. In a paper appearing online on September 8 in advance of print publication of the October 1 issue of the Journal of Clinical Investigation, Nicolas Bazan and colleagues from Louisiana State University identify a specific mechanism by which DHA is neuroprotective in AD.

A number of studies suggest a protective action of the fatty acid DHA in cognitive decline and in Alzheimer disease (AD). However, the molecular mechanism is not understood. In a paper appearing online on September 8 in advance of print publication of the October 1 issue of the Journal of Clinical Investigation, Nicolas Bazan and colleagues from Louisiana State University identify a specific mechanism by which DHA is neuroprotective in AD.

The authors report that DHA can decrease levels of the pathogenic Abeta peptides that are associated with Alzheimer disease pathology in human brain cells. Meanwhile, the synthesis of neuroprotectin D1 (NPD1), an endogenous DHA-derived messenger, is upregulated. NPD1 inhibits apoptosis triggered by Abeta peptides. In a human AD donor brain, the authors show that DHA and NPD1 are reduced in vulnerable brain regions.

This data raises the possibility that NPD1 is a key regulator of cell survival, and might be manipulated for the development of novel therapeutic strategies for neurodegenerative diseases.

###

TITLE: A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease

View the PDF of this article at: https://www.the-jci.org/article.php?id=25420


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The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


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Journal of Clinical Investigation. "Fatty Acids: Good For The Brain, Good For Alzheimer Disease." ScienceDaily. ScienceDaily, 11 September 2005. <www.sciencedaily.com/releases/2005/09/050911105120.htm>.
Journal of Clinical Investigation. (2005, September 11). Fatty Acids: Good For The Brain, Good For Alzheimer Disease. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2005/09/050911105120.htm
Journal of Clinical Investigation. "Fatty Acids: Good For The Brain, Good For Alzheimer Disease." ScienceDaily. www.sciencedaily.com/releases/2005/09/050911105120.htm (accessed April 16, 2014).

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