Featured Research

from universities, journals, and other organizations

Cellular Antacids Give Vaccines A Boost

Date:
September 13, 2005
Source:
Journal of Experimental Medicine
Summary:
Scientists in Italy have found that a drug that blocks acid buildup inside cells revs up the immune response to vaccines. Reporting in the September 19 issue of The Journal of Experimental Medicine, Vincenzo Barnaba and his team at the University of Rome show that people receiving booster shots against hepatitis B virus developed more robust immune responses if given a widely used anti-malaria drug called chloroquine.

Scientists in Italy have found that a drug that blocks acid buildupinside cells revs up the immune response to vaccines. Reporting in theSeptember 19 issue of The Journal of Experimental Medicine, VincenzoBarnaba and his team at the University of Rome show that peoplereceiving booster shots against hepatitis B virus developed more robustimmune responses if given a widely used anti-malaria drug calledchloroquine.

Many vaccines are made up of soluble proteins derived from dangerousviruses or bacteria. But because of the way these proteins are brokendown by cells, they do a poor job of prodding killer cells calledcytolytic T cells into action. Cytolytic T cells are responsible foridentifying and executing infected cells, so finding ways to get moreof these cells activated is an important goal for vaccine development.

Barnaba and his colleagues now show that exposing cells tochloroquine prevents the acidification of cellular compartments intowhich vaccine proteins are taken up. Normally these proteins would bedigested rapidly inside the compartment, but this is prevented bychloroquine because the degradation requires an acidic environment. Thechloroquine treatment also made the vesicles leaky, allowing theproteins to escape into the cytoplasm of the cell. From there, theycould be broken down such that small pieces of the protein aredisplayed to nearby cytolytic T cells; recognition of these smallpieces of protein activates the killer cells.

The demonstration that a single dose of chloroquine boostedhepatitis B virus-specific T cell responses in up to 70% of vaccinerecipients suggests that this readily available, oral drug might be apromising vaccine supplement.


Story Source:

The above story is based on materials provided by Journal of Experimental Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Experimental Medicine. "Cellular Antacids Give Vaccines A Boost." ScienceDaily. ScienceDaily, 13 September 2005. <www.sciencedaily.com/releases/2005/09/050913075010.htm>.
Journal of Experimental Medicine. (2005, September 13). Cellular Antacids Give Vaccines A Boost. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2005/09/050913075010.htm
Journal of Experimental Medicine. "Cellular Antacids Give Vaccines A Boost." ScienceDaily. www.sciencedaily.com/releases/2005/09/050913075010.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins