Featured Research

from universities, journals, and other organizations

Scientists Develop Screening Method For Pancreatic Cancer

Date:
September 21, 2005
Source:
University of Liverpool
Summary:
Scientists at the University of Liverpool have found a way of identifying families at high risk of pancreatic cancer.

Scientists at the University of Liverpool have found a way of identifying families at high risk of pancreatic cancer.

The team has developed a novel means of testing for pancreaticcancer that will enable doctors to treat the killer disease at itsearliest stages. They are also now able to show how the risk of cancerfor these patients changes with age.

The Liverpool-based study group known as EUROPAC (EuropeanRegistry Of Hereditary Pancreatitis And Familial Pancreatic Cancer),working in collaboration with a similar group in Germany, has shownthat familial pancreatic cancer develops at an increasingly younger ageas it is passed down generations - a phenomenon known as anticipation.

In the largest study of its kind, the team surveyed 600families with a history of pancreatic cancer and identified a subgroupof over 80 families whose lifetime risk of developing the cancer was 50per cent.

Dr Bill Greenhalf, from the University's Division of Surgeryand Oncology, said: "Of those families with the highest incidence ofpancreatic cancer, we found that members developed the disease at ayounger age in each generation. As well as giving important clues aboutthe nature of the disease, this allows a more accurate estimate of therisk an individual faces of developing cancer in the short term so wecan treat the cancer as soon as possible."

The team led by Dr Greenhalf has developed a novel method ofanalysing pancreatic juice, taken from patients in families with ahistory of pancreatic cancer. By analysing DNA scientists are able toidentify specific genetic mutations that indicate the chances of apatient developing the disease in the short term, ranging from a 0.1%chance to a 90% certainty.

Dr Greenhalf added: "Our research has provided strong evidence thatanticipation and pancreatic juice analysis are the most effective meansof screening for pancreatic cancer in families with a history of thedisease. We intend to carry out further trials of these techniques andhope the results encourage more widespread adoption of these screeningmethods."

###

The research is published in two separate papers in the academic journals, Gut and Gastroenterology.

Notes to editors

1. The Pancreas Treatment and Research Centre at the University of Liverpool is the largest of its kind in the UK.
2. Cancer of the pancreas is one of the ten most common cancers inBritain, killing 7,000 people every year. It is amongst the mostdifficult to detect and treat. There are very few early symptoms and somost patients present late. Only 15% of patients are suitable forsurgery - the only treatment available - and most sufferers die withina year of diagnosis.
3. The University of Liverpool is one of the UK's leading researchinstitutions. It attracts collaborative and contract researchcommissions from a wide range of national and internationalorganisations valued at more than 90 million annually.


Story Source:

The above story is based on materials provided by University of Liverpool. Note: Materials may be edited for content and length.


Cite This Page:

University of Liverpool. "Scientists Develop Screening Method For Pancreatic Cancer." ScienceDaily. ScienceDaily, 21 September 2005. <www.sciencedaily.com/releases/2005/09/050921081518.htm>.
University of Liverpool. (2005, September 21). Scientists Develop Screening Method For Pancreatic Cancer. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2005/09/050921081518.htm
University of Liverpool. "Scientists Develop Screening Method For Pancreatic Cancer." ScienceDaily. www.sciencedaily.com/releases/2005/09/050921081518.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins