Featured Research

from universities, journals, and other organizations

Experimental Compound Reveals Metabolic Disturbances In The Heart

Date:
October 1, 2005
Source:
University of Maryland Medical Center
Summary:
A national team of researchers, led by a cardiovascular nuclear medicine specialist at the University of Maryland Medical Center, has demonstrated for the first time that an experimental radioactive compound can show images of heart damage up to 30 hours after a brief interruption of blood flow and oxygen. The discovery may help physicians in emergency rooms and in their offices determine whether a patient's chest pain, which may have subsided hours earlier, is related to heart disease or something else, such as indigestion.

A national team of researchers, led by a cardiovascular nuclearmedicine specialist at the University of Maryland Medical Center, hasdemonstrated for the first time that an experimental radioactivecompound can show images of heart damage up to 30 hours after a briefinterruption of blood flow and oxygen. The discovery may helpphysicians in emergency rooms and in their offices determine whether apatient's chest pain, which may have subsided hours earlier, is relatedto heart disease or something else, such as indigestion. The results ofthe study appear today in Circulation Online and will appear in theprint version of Circulation on October 4, 2005.

"We are excited about this agent because it extends the time windowfor identifying myocardial ischemia, a common cause of chest pain, longafter the pain stops and blood flow to the heart returns to normal,"says lead investigator Vasken Dilsizian, M.D., professor of medicineand diagnostic radiology and nuclear medicine at the University ofMaryland School of Medicine and director of Cardiovascular NuclearMedicine at the University of Maryland Medical Center. "This probeprovides a direct connection to the cause of the chest pain withoutrequiring a treadmill stress test or use of a drug that produces stressto assess heart function," says Dr. Dilsizian.

Nuclear medicine combines computers, detectors and radioactivesubstances called radioisotopes to produce images of blood flow andbiochemical functions in the heart and other organs. The radioactivetracer evaluated for this study, known by the brand name Zemiva, linksa fatty acid to a radioisotope which is injected in the patient. Theresearchers used a technique called SPECT (Single Photon EmissionComputed Tomography) to evaluate the tracer in this study.

The heart normally uses fatty acid as its primary fuel sourcefor energy. Decreased blood flow to the heart, caused either bynarrowed or clogged arteries or increased demand on the heart duringstrenuous exercise, sets off a metabolic disturbance that slows down orhalts the way fatty acid is normally utilized. The condition is calledmyocardial ischemia. The disturbance causes the heart to switch fromfatty acid as its primary fuel to glucose. The new tracer test keys inon this metabolic disturbance and seemingly remembers the imprint of anepisode of reduced blood flow long after the episode, a process that iscalled "ischemic memory." According to Dr. Dilsizian, "When you imagethe heart, you see lack of or reduced fatty acid metabolism."

Thirty-two patients from four centers were enrolled in thestudy. To determine the accuracy of images acquired by Zemiva, theresearchers first identified patients who had evidence of myocardialischemia on a treadmill using a standard tracer called thalium toproduce SPECT images. Later, SPECT images of the same patients weretaken with the new tracer (Zemiva) injected at rest (without repeatingthe treadmill exercise), but no more that 30 hours after the exercisethalium test. The exercise-induced thalium-based images were comparedwith the rest-injected Zimeva images. The comparison showed the twotracers pointed to the same abnormality in the heart in over 90 percentof the cases. This suggests that disturbances in fatty acid metabolismcan persist up to 30 hours after an ischemic episode, which can beimaged with the new tracer Zemiva.

Additional testing will be required before this new agent can be approved by the U.S. Food and Drug Administration.

The research team also included Timothy M. Bateman, M.D.,Cardiovascular Consultants, Kansas City, MO; Steven R. Bergmann, M.D.,Ph.D., College of Physicans and Surgeons of Columbia University; RogerDes Prez, M.D., Oklahoma Heart Institute; Martin Y. Magram, M.D.,University of Maryland Medical Center and the University of MarylandSchool of Medicine; Anne E. Goodbody, Ph.D., and John W. Babich, Ph.D.,Molecular Insight Pharmaceuticals, and James E. Udelson, M.D.,Tufts-New England Medical Center and Tufts Univeristy School ofMedicine. The study was funded by Molecular Insight Pharmaceuticals,maker of Zemiva.


Story Source:

The above story is based on materials provided by University of Maryland Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University of Maryland Medical Center. "Experimental Compound Reveals Metabolic Disturbances In The Heart." ScienceDaily. ScienceDaily, 1 October 2005. <www.sciencedaily.com/releases/2005/09/050928234558.htm>.
University of Maryland Medical Center. (2005, October 1). Experimental Compound Reveals Metabolic Disturbances In The Heart. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2005/09/050928234558.htm
University of Maryland Medical Center. "Experimental Compound Reveals Metabolic Disturbances In The Heart." ScienceDaily. www.sciencedaily.com/releases/2005/09/050928234558.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins