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Substance Lining Blood Vessels May Cause Cardiovascular Disease

Date:
October 10, 2005
Source:
Public Library of Science
Summary:
A paper published in the freely-available online journal PLoS Medicine reveals that pathophysiological concentrations of asymmetric dimethylarginine elicit significant changes in coronary artery endothelial cell gene expression and highlight specific molecular pathways for further investigation.

ADMA affects on endothelial gene expression.
Credit: Photo : Smith et al.

ADMA is already recognized to be an important indicator of cardiovascular disease: higher levels are found in people with a range of problems of the heart and blood vessel system. These levels have also been used to predict the risk of such problems in otherwise healthy male patients and pregnant women. However, Caroline Smith and colleagues from University College London attempted to uncover whether ADMA actually causes damage rather than just being a marker of risk. They did this by treating cells from the blood vessel lining with high doses of ADMA and measured the effects. The researchers found that a number of genes were more active when the cells were exposed to higher ADMA levels, including those that previous studies suggest are involved in lung, heart and kidney disease. The team also examined tissues from mice with high ADMA levels and found that the genes exhibiting changes were those known to be associated with cardiovascular disease and hypertension.

This exploratory research paves the way for new studies to examine the exact function that those genes responding to higher ADMA levels may play in cardiovascular disease. In the long term, understanding of the mechanisms associated with increased ADMA levels may lead to new strategies for treatment or prevention.

###

Citation: Smith CL, Anthony S, Hubank M, Leiper JM, Vallance P (2005) Effects of ADMA upon gene expression: An insight into the pathophysiological significance of raised plasma ADMA. PLoS Med 2(10): e264.


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The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


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Public Library of Science. "Substance Lining Blood Vessels May Cause Cardiovascular Disease." ScienceDaily. ScienceDaily, 10 October 2005. <www.sciencedaily.com/releases/2005/10/051010100906.htm>.
Public Library of Science. (2005, October 10). Substance Lining Blood Vessels May Cause Cardiovascular Disease. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2005/10/051010100906.htm
Public Library of Science. "Substance Lining Blood Vessels May Cause Cardiovascular Disease." ScienceDaily. www.sciencedaily.com/releases/2005/10/051010100906.htm (accessed April 18, 2014).

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