Featured Research

from universities, journals, and other organizations

Substance Lining Blood Vessels May Cause Cardiovascular Disease

Date:
October 10, 2005
Source:
Public Library of Science
Summary:
A paper published in the freely-available online journal PLoS Medicine reveals that pathophysiological concentrations of asymmetric dimethylarginine elicit significant changes in coronary artery endothelial cell gene expression and highlight specific molecular pathways for further investigation.

ADMA affects on endothelial gene expression.
Credit: Photo : Smith et al.

Related Articles


ADMA is already recognized to be an importantindicator of cardiovascular disease: higher levels are found in peoplewith a range of problems of the heart and blood vessel system. Theselevels have also been used to predict the risk of such problems inotherwise healthy male patients and pregnant women. However, CarolineSmith and colleagues from University College London attempted touncover whether ADMA actually causes damage rather than just being amarker of risk. They did this by treating cells from the blood vessellining with high doses of ADMA and measured the effects. Theresearchers found that a number of genes were more active when thecells were exposed to higher ADMA levels, including those that previousstudies suggest are involved in lung, heart and kidney disease. Theteam also examined tissues from mice with high ADMA levels and foundthat the genes exhibiting changes were those known to be associatedwith cardiovascular disease and hypertension.

This exploratoryresearch paves the way for new studies to examine the exact functionthat those genes responding to higher ADMA levels may play incardiovascular disease. In the long term, understanding of themechanisms associated with increased ADMA levels may lead to newstrategies for treatment or prevention.

###

Citation: SmithCL, Anthony S, Hubank M, Leiper JM, Vallance P (2005) Effects of ADMAupon gene expression: An insight into the pathophysiologicalsignificance of raised plasma ADMA. PLoS Med 2(10): e264.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Substance Lining Blood Vessels May Cause Cardiovascular Disease." ScienceDaily. ScienceDaily, 10 October 2005. <www.sciencedaily.com/releases/2005/10/051010100906.htm>.
Public Library of Science. (2005, October 10). Substance Lining Blood Vessels May Cause Cardiovascular Disease. ScienceDaily. Retrieved April 25, 2015 from www.sciencedaily.com/releases/2005/10/051010100906.htm
Public Library of Science. "Substance Lining Blood Vessels May Cause Cardiovascular Disease." ScienceDaily. www.sciencedaily.com/releases/2005/10/051010100906.htm (accessed April 25, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, April 25, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

85 Killed in Niger by Meningitis Since Start of Year

85 Killed in Niger by Meningitis Since Start of Year

AFP (Apr. 24, 2015) A meningitis outbreak in Niger has killed 85 people since the start of the year prompting authorities to close schools in the capital Niamey until Monday. Video provided by AFP
Powered by NewsLook.com
C-Section Births a Trend in Brazil

C-Section Births a Trend in Brazil

AFP (Apr. 24, 2015) More than half of Brazil&apos;s babies are born via cesarean section, as mothers and doctors opt for a faster and less painful experience despite the health risks. Duration: 02:02 Video provided by AFP
Powered by NewsLook.com
Anti-Malaria Jab Hope

Anti-Malaria Jab Hope

Reuters - News Video Online (Apr. 24, 2015) The world&apos;s first anti-malaria vaccine could get the go-ahead for use in Africa from October if approved by international regulators. Paul Chapman reports. Video provided by Reuters
Powered by NewsLook.com
3D Food Printing: The Meal of the Future?

3D Food Printing: The Meal of the Future?

AP (Apr. 23, 2015) Developers of 3D food printing hope the culinary technology will revolutionize the way we cook and eat. (April 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins