Featured Research

from universities, journals, and other organizations

Vanadium Appears To Play Role In Speeding Recovery From Infections

Date:
October 12, 2005
Source:
University of Illinois at Urbana-Champaign
Summary:
Dietary supplements containing vanadium are used by body builders to help beef up muscles and by some diabetic people to control blood sugar. New research now suggests the naturally occurring but easily toxic element may help prepare the body to recover speedily from infections from gram-negative organisms such as E. coli.

CHAMPAIGN, Ill. -- Dietary supplements containing vanadium are used bybody builders to help beef up muscles and by some diabetic people tocontrol blood sugar. New research now suggests the naturally occurringbut easily toxic element may help prepare the body to recover speedilyfrom infections from gram-negative organisms such as E. coli.

Related Articles


In research at the University of Illinois at Urbana-Champaign,scientists are trying to understand how recovery might be encouragedand why people with diabetes tend to have lingering behavioral symptomssuch as fatigue and apathy long after many infections end.

Their latest research found that mice given vanadium -- in itstypical vanadyl sulfate form -- before exposure to a pathogen spedrecovery in both diabetic and non-diabetic animals. They also testedpre-treatment with insulin-like growth factor (IGF-1), which vanadiummimics, but only the non-diabetic mice recovered quickly afterexposure.

The new paper appeared on line Oct. 10 ahead of regularjournal publication in the Proceedings of the National Academy ofSciences.

Researchers Daniel R. Johnson, a doctoral student, and Dr.Gregory Freund, head of the pathology department in the College ofMedicine at Urbana-Champaign, don't suggest adding vanadium supplementsto everyday diets. However, they said, the findings raise questionsabout just how it works and how it might be useful in speedingrecovery.

The amount of vanadium used in the study was comparable to thatfound in nutritional supplements. While its nutritional value isunclear, the body needs an estimated 10 to 20 micrograms a day andobtains it mostly from plant material. Vanadium in much higher levelsbecomes toxic. Its use for building muscles has not been confirmed, butvanadium has improved insulin sensitivity and reduced blood sugar indiabetic people.

In their research, Johnson first administered a low dose oflipopolysaccharide (LPS), a molecule present on E. coli and othergram-negative bacteria, to both diabetic and non-diabetic mice afterthey had been given IGF-1. Non-diabetic mice recovered more quicklythan diabetic mice, suggesting, he said, an insulin resistance state inthe diabetic animals.

Next, experimental mice were pre-treated with vanadyl sulfatebefore exposure to LPS. Recovery after illness of the vanadium-treatedmice, diabetic or not, was 50 percent faster than that of the untreatedcontrol mice.

"With vanadyl sulfate being like IGF-1, we expected to seeresistance in the diabetic animals, but we didn't see that," Johnsonsaid. "We saw similar improvement. Thus it must have been actingthrough a different pathway than do IGF-1 or insulin."

Johnson and Freund, also an adjunct professor of animalsciences and a researcher in the immunophysiology and behavior programat Illinois, theorize it may be vanadium's metal-related shape or itsability to inhibit tyrosine phosphatases, which help to modulatesignaling proteins, in the immune system. Freund and colleagues lastyear documented a connection between serine phosphorylation andanti-inflammatory cytokines.

"Diabetes affects millions of people," Freund said. "It is hardto overcome many of the problems in a nutritionally dependent fashion.This research implies that metals that are trace elements may have moreimportance than we realize to human health, not only in preventingdiseases but also in making you feel better."

It's possible, Johnson said, that takingvanadyl-sulfate-containing supplements beginning two weeks beforepossible exposure to gram-negative organisms might help speed recoveryfrom subsequent infection.

###

Co-authors with Freund and Johnson were Jason C. O'Connor, apostdoctoral researcher in animal sciences, and Robert Dantzer, anadjunct professor in the department of animal sciences and professor atthe French National Center for Scientific Research.

The National Institutes of Health, American Heart Association and U. of I. Agricultural Experiment Station funded the research.


Story Source:

The above story is based on materials provided by University of Illinois at Urbana-Champaign. Note: Materials may be edited for content and length.


Cite This Page:

University of Illinois at Urbana-Champaign. "Vanadium Appears To Play Role In Speeding Recovery From Infections." ScienceDaily. ScienceDaily, 12 October 2005. <www.sciencedaily.com/releases/2005/10/051012084200.htm>.
University of Illinois at Urbana-Champaign. (2005, October 12). Vanadium Appears To Play Role In Speeding Recovery From Infections. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2005/10/051012084200.htm
University of Illinois at Urbana-Champaign. "Vanadium Appears To Play Role In Speeding Recovery From Infections." ScienceDaily. www.sciencedaily.com/releases/2005/10/051012084200.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) — It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) — As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
Dads-To-Be Also Experience Hormone Changes During Pregnancy

Dads-To-Be Also Experience Hormone Changes During Pregnancy

Newsy (Dec. 18, 2014) — A study from University of Michigan researchers found that expectant fathers see a decrease in testosterone as the baby's birth draws near. Video provided by Newsy
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) — Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins