Featured Research

from universities, journals, and other organizations

Vanadium Appears To Play Role In Speeding Recovery From Infections

Date:
October 12, 2005
Source:
University of Illinois at Urbana-Champaign
Summary:
Dietary supplements containing vanadium are used by body builders to help beef up muscles and by some diabetic people to control blood sugar. New research now suggests the naturally occurring but easily toxic element may help prepare the body to recover speedily from infections from gram-negative organisms such as E. coli.

CHAMPAIGN, Ill. -- Dietary supplements containing vanadium are used by body builders to help beef up muscles and by some diabetic people to control blood sugar. New research now suggests the naturally occurring but easily toxic element may help prepare the body to recover speedily from infections from gram-negative organisms such as E. coli.

In research at the University of Illinois at Urbana-Champaign, scientists are trying to understand how recovery might be encouraged and why people with diabetes tend to have lingering behavioral symptoms such as fatigue and apathy long after many infections end.

Their latest research found that mice given vanadium -- in its typical vanadyl sulfate form -- before exposure to a pathogen sped recovery in both diabetic and non-diabetic animals. They also tested pre-treatment with insulin-like growth factor (IGF-1), which vanadium mimics, but only the non-diabetic mice recovered quickly after exposure.

The new paper appeared on line Oct. 10 ahead of regular journal publication in the Proceedings of the National Academy of Sciences.

Researchers Daniel R. Johnson, a doctoral student, and Dr. Gregory Freund, head of the pathology department in the College of Medicine at Urbana-Champaign, don't suggest adding vanadium supplements to everyday diets. However, they said, the findings raise questions about just how it works and how it might be useful in speeding recovery.

The amount of vanadium used in the study was comparable to that found in nutritional supplements. While its nutritional value is unclear, the body needs an estimated 10 to 20 micrograms a day and obtains it mostly from plant material. Vanadium in much higher levels becomes toxic. Its use for building muscles has not been confirmed, but vanadium has improved insulin sensitivity and reduced blood sugar in diabetic people.

In their research, Johnson first administered a low dose of lipopolysaccharide (LPS), a molecule present on E. coli and other gram-negative bacteria, to both diabetic and non-diabetic mice after they had been given IGF-1. Non-diabetic mice recovered more quickly than diabetic mice, suggesting, he said, an insulin resistance state in the diabetic animals.

Next, experimental mice were pre-treated with vanadyl sulfate before exposure to LPS. Recovery after illness of the vanadium-treated mice, diabetic or not, was 50 percent faster than that of the untreated control mice.

"With vanadyl sulfate being like IGF-1, we expected to see resistance in the diabetic animals, but we didn't see that," Johnson said. "We saw similar improvement. Thus it must have been acting through a different pathway than do IGF-1 or insulin."

Johnson and Freund, also an adjunct professor of animal sciences and a researcher in the immunophysiology and behavior program at Illinois, theorize it may be vanadium's metal-related shape or its ability to inhibit tyrosine phosphatases, which help to modulate signaling proteins, in the immune system. Freund and colleagues last year documented a connection between serine phosphorylation and anti-inflammatory cytokines.

"Diabetes affects millions of people," Freund said. "It is hard to overcome many of the problems in a nutritionally dependent fashion. This research implies that metals that are trace elements may have more importance than we realize to human health, not only in preventing diseases but also in making you feel better."

It's possible, Johnson said, that taking vanadyl-sulfate-containing supplements beginning two weeks before possible exposure to gram-negative organisms might help speed recovery from subsequent infection.

###

Co-authors with Freund and Johnson were Jason C. O'Connor, a postdoctoral researcher in animal sciences, and Robert Dantzer, an adjunct professor in the department of animal sciences and professor at the French National Center for Scientific Research.

The National Institutes of Health, American Heart Association and U. of I. Agricultural Experiment Station funded the research.


Story Source:

The above story is based on materials provided by University of Illinois at Urbana-Champaign. Note: Materials may be edited for content and length.


Cite This Page:

University of Illinois at Urbana-Champaign. "Vanadium Appears To Play Role In Speeding Recovery From Infections." ScienceDaily. ScienceDaily, 12 October 2005. <www.sciencedaily.com/releases/2005/10/051012084200.htm>.
University of Illinois at Urbana-Champaign. (2005, October 12). Vanadium Appears To Play Role In Speeding Recovery From Infections. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2005/10/051012084200.htm
University of Illinois at Urbana-Champaign. "Vanadium Appears To Play Role In Speeding Recovery From Infections." ScienceDaily. www.sciencedaily.com/releases/2005/10/051012084200.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) — Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) — In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) — A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) — The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins