Featured Research

from universities, journals, and other organizations

UCLA Researchers Identify How Antibody Blocks Prostate Cancer Growth In Animal Models

Date:
October 19, 2005
Source:
University of California - Los Angeles
Summary:
Researchers at UCLA's Jonsson Cancer Center have uncovered the mechanism by which an antibody blocks the growth of prostate cancer in animal models, a discovery that could pave the way for development of a new molecularly targeted therapy.

Researchers at UCLA's Jonsson Cancer Center have uncovered themechanism by which an antibody blocks the growth of prostate cancer inanimal models, a discovery that could pave the way for development of anew molecularly targeted therapy.

The antibody, called 1G8 and discovered by UCLA scientists, signalsthe prostate cancer cells to stop growing and die, said Dr. Robert E.Reiter, a Jonsson Cancer Center researcher and professor of urology.The antibody proved effective in several different animal models ofprostate cancer, Reiter said, indicating that is could be a potentcancer fighter.

The research appears in the Oct. 15 issue of Cancer Research, apeer-reviewed journal published by the American Association for CancerResearch.

The 1G8 antibody binds to prostate stem cell antigen or PSCA, acell surface protein discovered by Reiter that is found in about 95percent of early stage prostate cancers and about 87 percent ofprostate cancers that have spread to the bones. PSCA also is found inbladder and pancreatic cancers, Reiter and his team previouslydiscovered, so a new targeted therapy developed from the antibody mayalso prove effective in battling those cancers.

"The big question with antibodies has been, how do they work?"said Reiter, senior author of the study. "Do antibodies recruit theimmune system to kill the cancer or do they send a signal that tellsthe cancer cells to stop growing? This study shows how the antibodyworks, so we'll know how to apply it in the clinical setting."

The 1G8 antibody has two parts, one that binds with PSCA andone that binds with macrophages, the immune system's killer cells.Reiter and his team fragmented the antibody, separating the part thatbinds to PSCA and testing it alone in the animal models to see how itaffected the prostate cancer cells. Even without engaging an immuneresponse, the antibody blocked the growth of the prostate cancer cells.

"The fragments we created were unable to bind to the immunesystem, but they retained the same activity the whole antibody showed,so we proved that 1G8 must work by signaling the cancer cells to stopgrowing and die," Reiter said. "That's important because it provides alot more information about what PSCA does and how antibodies work. Italso suggests that PSCA is a very good target for therapy and that ourantibody, in particular, is extremely active and binds to a region onthe cell surface protein that may be an optimal target for a newtreatment."

Molecularly targeted therapies are the new wave of cancertherapy, homing in on what is broken or mutated in the cancer cells andleaving the healthy cells alone. Because they only target the cancercells, these therapies typically cause few side effects, if any, andare much easier for patients to tolerate.

The next step, Reiter said, is to test the 1G8 antibody in human clinical trials, probably in about a year.

This study is the result of years of laboratory research and ispart of the Jonsson Cancer Center's Specialized Program of ResearchExcellence in prostate cancer, a National Cancer Institute-fundedprogram to discover new and better ways to prevent, detect and treatprostate cancer.

"This work from start to finish is a UCLA discovery, truetranslational research that will go from the lab bench to the patientbedside," Reiter said.

Prostate cancer will strike more than 232,000 men in theUnited States this year alone, killing more than 30,350. Prostatecancer is the second leading cause of cancer death in men, according tothe American Cancer Society.

###

UCLA's Jonsson Comprehensive Cancer Center comprises more than 240researchers and clinicians engaged in cancer research, prevention,detection, control, treatment and education. One of the nation'slargest comprehensive cancer centers, the Jonsson Cancer Center isdedicated to promoting research and translating the results intoleading-edge clinical studies. In July 2005, the Jonsson Cancer Centerwas named the best cancer center in the western United States by U.S.News & World Report, a ranking it has held for six consecutiveyears.


Story Source:

The above story is based on materials provided by University of California - Los Angeles. Note: Materials may be edited for content and length.


Cite This Page:

University of California - Los Angeles. "UCLA Researchers Identify How Antibody Blocks Prostate Cancer Growth In Animal Models." ScienceDaily. ScienceDaily, 19 October 2005. <www.sciencedaily.com/releases/2005/10/051018224620.htm>.
University of California - Los Angeles. (2005, October 19). UCLA Researchers Identify How Antibody Blocks Prostate Cancer Growth In Animal Models. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2005/10/051018224620.htm
University of California - Los Angeles. "UCLA Researchers Identify How Antibody Blocks Prostate Cancer Growth In Animal Models." ScienceDaily. www.sciencedaily.com/releases/2005/10/051018224620.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
New Drug Could Reduce Cardiovascular Deaths

New Drug Could Reduce Cardiovascular Deaths

Newsy (Aug. 30, 2014) The new drug from Novartis could reduce cardiovascular deaths by 20 percent compared to other similar drugs. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins