Featured Research

from universities, journals, and other organizations

Cheek Cells Used To Identify Lung Cancer

Date:
November 8, 2005
Source:
American College of Chest Physicians
Summary:
In a new study presented at CHEST 2005, the 71st annual international scientific assembly of the American College of Chest Physicians (ACCP), scientists found that buccal mucosa, or cells scraped from the inner part of the cheek, may contain information that separates patients with lung cancer from high-risk negatives, a finding that may support cheek cell analysis as a simple and inexpensive early screening method for patients at risk for lung cancer.

A novel test for lung cancer uses inner cheek cells to identify the disease in high-risk patients. In a new study presented at CHEST 2005, the 71st annual international scientific assembly of the American College of Chest Physicians (ACCP), scientists found that buccal mucosa, or cells scraped from the inner part of the cheek, may contain information that separates patients with lung cancer from high-risk negatives, a finding that may support cheek cell analysis as a simple and inexpensive early screening method for patients at risk for lung cancer.

"Previous research has shown that cell nuclear changes can extend a significant distance from the site of a malignancy. We have already conducted a successful clinical trial for our sputum test for lung cancer. New data suggest that the effects of lung cancer can also be measured as far away as skin cells in the mouth," said lead researcher Bojana Turic, MD, Director of Clinical and Regulatory Affairs, Perceptronix, Inc, Vancouver, BC, Canada. "Although a clinical test based on buccal cells is still in development, the method of analyzing cheek cells to detect cancer is showing interesting results."

Dr. Turic and colleagues analyzed randomized cheek scrapings of 150 confirmed lung cancer patients and 990 high-risk patients, using Automated Quantitative Cytometry (AQC). Able to detect subtle changes in buccal cell nuclei, the AQC system analyzes several thousand cells per specimen and reduces the data to a single score that predicts the likelihood of the presence of cancer. Of the buccal specimens collected, the AQC showed 66 percent sensitivity at 70 percent specificity overall, and 61 percent sensitivity for stage I lung cancer, which comprised 47 of the 150 cases.

"Stage I lung cancer is considered treatable, but most lung cancers are currently detected beyond stage I," said Dr. Turic. "We believe that early detection is the key to reducing lung cancer mortality and have focused our approach around detecting stage I lung cancer."

Although the test is not intended for screening the general population, researchers are hopeful that the AQC method will become an accurate, noninvasive, inexpensive, and easy-to-administer lung cancer detection test for patients at risk for lung cancer.

"A sufficient amount of cells can be collected by scraping the inside of the cheek with a small wooden spatula similar to a tongue depressor," said Dr. Turic. "Ultimately, this test could be administered in primary care settings or dental offices. The procedure is simple enough that specimen collection could be done by patients themselves." Researchers stress that additional clinical testing of the AQC method is needed, using a sufficient number and appropriate sample of patients in order to validate the test's performance.

Researchers have also developed a sputum test that utilizes the AQC method. They hope to receive Canadian regulatory approval in early 2006. Both tests are intended to provide pulmonary physicians with valuable information to help them manage patients at risk of developing or suspected of having lung cancer.

"Each year, great strides are made in the detection, diagnosis, and treatment of lung cancer," said W. Michael Alberts, MD, FCCP, President of the American College of Chest Physicians. "As with any new cancer screening or therapy, rigorous testing must be conducted in order to establish its safety and efficacy. Therefore, we must remain cautious but hopeful regarding new advances in their initial testing stages."

###

CHEST 2005 is the 71st annual international scientific assembly of the American College of Chest Physicians, held October 29 through November 3 in Montreal, Quebec, Canada. ACCP represents 16,500 members who provide clinical respiratory, critical care, sleep, and cardiothoracic patient care in the United States and throughout the world. The ACCP's mission is to promote the prevention and treatment of diseases of the chest through leadership, education, research, and communication. For more information about the ACCP, please visit the ACCP Web site at www.chestnet.org.


Story Source:

The above story is based on materials provided by American College of Chest Physicians. Note: Materials may be edited for content and length.


Cite This Page:

American College of Chest Physicians. "Cheek Cells Used To Identify Lung Cancer." ScienceDaily. ScienceDaily, 8 November 2005. <www.sciencedaily.com/releases/2005/11/051108082455.htm>.
American College of Chest Physicians. (2005, November 8). Cheek Cells Used To Identify Lung Cancer. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2005/11/051108082455.htm
American College of Chest Physicians. "Cheek Cells Used To Identify Lung Cancer." ScienceDaily. www.sciencedaily.com/releases/2005/11/051108082455.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins