Featured Research

from universities, journals, and other organizations

New Gene Silencing Therapy For Cervical Cancer

Date:
November 21, 2005
Source:
University of Queensland
Summary:
Researchers at The University of Queensland's (UQ) Centre for Immunology and Cancer Research (CICR), based at the Princess Alexandra Hospital, have pioneered a new approach for the treatment of cervical cancer.

Dr Nigel McMillan.
Credit: Image courtesy of University of Queensland

Researchers at The University of Queensland's (UQ) Centre for Immunology and Cancer Research (CICR), based at the Princess Alexandra Hospital, have pioneered a new approach for the treatment of cervical cancer.

Related Articles


Lead researcher Dr Nigel McMillan said the finding was based on the method of "gene silencing", a novel technique to target and turn off single genes in a cell.

"Our research shows not only can we stop cervical cancer cells from growing in the test tube, but we can also completely eliminate the formation of cancer tumours in animal models," Dr McMillan said.

Professor Ian Frazer, Director of the CICR and developer of a vaccine for cervical cancer, said the research represented a significant step towards developing gene therapy for cervical cancer.

Cervical cancer is the leading cause of cancer death in women aged 25-50 worldwide and causes around 300 deaths per year in Australia.

Cervical cancer is caused by infection with the human papillomavirus and is the result of the over-production of two viral cancer-causing genes called E6 and E7.

The research team was able to turn off the production of these genes in cancer cells, resulting in the death of the cancer.

"Because these viral genes are foreign we can treat normal cells and they remain unaffected by our treatment," Dr McMillan said.

"Development of treatments for humans would be an advance over the current treatments, radiation and chemotherapy, which kill not only cancer cells but also normal cells that leads to hair loss and nausea.

"We envisage such treatment will be used for all forms of cervical cancer including the premalignant lesions picked up by the pap smear and especially for advanced cervical cancers where the cancer has moved to other sites such as the lung or liver."

Dr McMillan said the research also showed gene silencing enhanced the effect of chemotherapy by up to four times.

He said the findings suggest a cancer-specific treatment for advanced cervical cancers will be possible either alone or in combination with current treatments.

He said the next stage of research will focus on the development of materials for human trials to allow proper delivery of the drug to patients and to investigate whether other cancer types can be treated this way. A treatment using this technique is at least three years away.



Story Source:

The above story is based on materials provided by University of Queensland. Note: Materials may be edited for content and length.


Cite This Page:

University of Queensland. "New Gene Silencing Therapy For Cervical Cancer." ScienceDaily. ScienceDaily, 21 November 2005. <www.sciencedaily.com/releases/2005/11/051118160925.htm>.
University of Queensland. (2005, November 21). New Gene Silencing Therapy For Cervical Cancer. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2005/11/051118160925.htm
University of Queensland. "New Gene Silencing Therapy For Cervical Cancer." ScienceDaily. www.sciencedaily.com/releases/2005/11/051118160925.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins