Featured Research

from universities, journals, and other organizations

Study Shows Nicotine Vaccine Has Promise For Helping Smokers Quit

Date:
November 29, 2005
Source:
University of Minnesota
Summary:
A University of Minnesota study indicates that the nicotine vaccine NicVax, which is now being tested in humans, appears safe, well-tolerated, and a potentially effective method for helping smokers kick the habit.

A University of Minnesota study indicates that the nicotine vaccine NicVax, which is now being tested in humans, appears safe, well-tolerated, and a potentially effective method for helping smokers kick the habit.

Dorothy Hatsukami, Ph.D., director of the University of Minnesota Cancer Center's Transdisciplinary Tobacco Use Research Center (TTURC), is the lead author on this study. The 38-week study included 68 active smokers who were randomly assigned to receive one of three different doses of the vaccine or a placebo. The findings are published in the current issue of the journal Clinical Pharmacology and Therapeutics.

"The vaccine works by producing antibodies that specifically bind to nicotine and thereby prevent much of the nicotine from entering the brain," Hatsukami said. "This process potentially reduces the pleasurable effects from smoking and reduces the addiction to nicotine."

The vaccine may become a new option for helping the approximately 45 million people in the United States who smoke. In 2004, the rate for smoking in Minnesota was about the same as the national average of 20.9 percent.

"More research needs to be done, but at this point, our results show the vaccine is safe and well-tolerated," Hatsukami said. "We found the vaccine has few side effects on the central nervous system because the antibody itself is targeted specifically for nicotine and does not alter any functions of the brain."

Additionally, she says that while this study was not designed to test the treatment effect, 38 percent of the participants in the high-dose vaccine group quit smoking for at least 30 days.

"This result was an impressive and completely unexpected finding because the study was not focused on helping smokers quit smoking," she noted. "In fact, to participate in the study, smokers had to attest that they did not have a planned quit date for the next six months."

Cigarettes are linked to a number of diseases, the leading being lung cancer which is the number one cause of cancer-related deaths in the United States and in Minnesota. This year in the United States, more than 170,000 people will be told that they have lung cancer and 160,000 will die from it. In Minnesota, more than 2,600 residents will be diagnosed with lung cancer this year, and nearly 2,500 people will die from it.

Hatsukami conducted this study in collaboration with researchers at the University of Wisconsin and University of Nebraska. This study was sponsored by the National Institute of Drug Abuse and Nabi Biopharmaceuticals, developer of the NicVax vaccine. Paul Pentel, M.D., with Hennepin County Medical Center in Minneapolis, previously evaluated the vaccine in rats and found that the vaccine-induced antibodies led to reduced levels of nicotine in the brain. His research also showed that the nicotine-vaccinated rats reduced their intake of nicotine compared with rats not given the vaccine. Those results led to testing the vaccine in humans. This study reported by Hatsukami is the latest in several Phase 1 and 2 human clinical trials.

According to Hatsukami, the most commonly reported side effect was an ache and tenderness in the area of the arm where the vaccine was injected. Some of the participants also reported headaches and muscle pain, which in all cases went away in a few days.

"No differences were noted in withdrawal symptoms between participants who received the vaccine and those who got the placebo," Hatsukami said. "We also did not see a compensatory smoking behavior, meaning that vaccinated participants did not puff harder on cigarettes or smoke more cigarettes to make up for the lower levels of nicotine delivered to the brain." More research is required because other questions about the vaccine need to be answered, such as how long the effectiveness of the vaccine will last for a smoker and whether the vaccine can be used to prevent people who quit from relapsing and starting to smoke again.

"Our findings add to scientific information about nicotine vaccine and provide the basis for additional research to answer those questions," Hatsukami said.


Story Source:

The above story is based on materials provided by University of Minnesota. Note: Materials may be edited for content and length.


Cite This Page:

University of Minnesota. "Study Shows Nicotine Vaccine Has Promise For Helping Smokers Quit." ScienceDaily. ScienceDaily, 29 November 2005. <www.sciencedaily.com/releases/2005/11/051128194749.htm>.
University of Minnesota. (2005, November 29). Study Shows Nicotine Vaccine Has Promise For Helping Smokers Quit. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2005/11/051128194749.htm
University of Minnesota. "Study Shows Nicotine Vaccine Has Promise For Helping Smokers Quit." ScienceDaily. www.sciencedaily.com/releases/2005/11/051128194749.htm (accessed September 1, 2014).

Share This




More Mind & Brain News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Coffee Then Napping: The (New) Key To Alertness

Coffee Then Napping: The (New) Key To Alertness

Newsy (Aug. 30, 2014) Researchers say having a cup of coffee then taking a nap is more effective than a nap or coffee alone. Video provided by Newsy
Powered by NewsLook.com
Young Entrepreneurs Get $100,000, If They Quit School

Young Entrepreneurs Get $100,000, If They Quit School

AFP (Aug. 29, 2014) Twenty college-age students are getting 100,000 dollars from a Silicon Valley leader and a chance to live in San Francisco in order to work on the start-up project of their dreams, but they have to quit school first. Duration: 02:20 Video provided by AFP
Powered by NewsLook.com
Baby Babbling Might Lead To Faster Language Development

Baby Babbling Might Lead To Faster Language Development

Newsy (Aug. 29, 2014) A new study suggests babies develop language skills more quickly if their parents imitate the babies' sounds and expressions and talk to them often. Video provided by Newsy
Powered by NewsLook.com
Electrical Stimulation Boosts Brain Function, Study Says

Electrical Stimulation Boosts Brain Function, Study Says

Newsy (Aug. 29, 2014) Researchers found an improvement in memory and learning function in subjects who received electric pulses to their brains. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins