Featured Research

from universities, journals, and other organizations

Endotoxins In House Dust Pose A Significant Risk For Asthma

Date:
December 1, 2005
Source:
American Thoracic Society
Summary:
Exposure to household endotoxin levels poses a significant risk for asthma, according to the first nationwide sampling of house dust.

Exposure to household endotoxin levels poses a significant risk for asthma, according to the first nationwide sampling of house dust.

Related Articles


The study appears in the first issue for December 2005 of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

Endotoxins are toxic substances associated with the outer membrane of certain gram-negative bacteria. These molecules are bound to the bacterial cell wall and are released when the bacterium ruptures or disintegrates. According to the authors, inhalation exposure to endotoxins is common in homes. Indoor sources include: dust, pets, humidifiers, pests, and outdoor air.

Past studies have shown that exposure can cause lung inflammation.

Peter S. Thorne, Ph.D., of the Environmental Health Sciences Research Center at the University of Iowa, Iowa City, and five associates, evaluated 2,456 residents in 831 homes selected to represent the demographic characteristics of the U.S. population. The investigators took 2,552 house dust samples from five locations within the homes, including bedroom floors, bedding, family room floors, sofa surfaces, and kitchen floors.

"This study clearly demonstrates significant relationships between household endotoxin and diagnosed asthma, recent asthma symptoms, current use of asthma medications, and wheezing," said Dr. Thorne. "No effect was observed of allergy status on the relationship between endotoxin and asthma outcomes. This suggests that current endotoxin exposure may have little impact on allergy status and that airway inflammation is the most significant effect of endotoxin exposure in a cross-section of the population."

The authors found the strongest relationship between asthma, asthma medications, and wheezing came from endotoxin levels in bedroom floor and bedding dust. However, the effects were observed only in adults and not in children.

Moreover, the investigators also noted that the endotoxin concentrations were highest in kitchen and living room floor dust, and lowest for bedding (including mattress and pillow).

"The mean concentration of endotoxin in the kitchen floor dust was 2.3-fold higher than bedroom floor dust and 4.3-fold higher than bedding dust," said Dr. Thorne.

Two field workers visited each household and took answers from residents to detailed questionnaires, conducted a home inspection, and vacuumed dust into an in-line filter.

The study yielded an 11.3 percent prevalence rate for diagnosed asthma among the homes surveyed. This figure compared favorably with the 11.1 percent prevalence rate of diagnosed asthma associated with the 2002 National Health Interview Survey.

The authors also noted that their national survey demonstrated that U.S. household endotoxin exposure levels were higher than those in Europe.



Story Source:

The above story is based on materials provided by American Thoracic Society. Note: Materials may be edited for content and length.


Cite This Page:

American Thoracic Society. "Endotoxins In House Dust Pose A Significant Risk For Asthma." ScienceDaily. ScienceDaily, 1 December 2005. <www.sciencedaily.com/releases/2005/12/051201081408.htm>.
American Thoracic Society. (2005, December 1). Endotoxins In House Dust Pose A Significant Risk For Asthma. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2005/12/051201081408.htm
American Thoracic Society. "Endotoxins In House Dust Pose A Significant Risk For Asthma." ScienceDaily. www.sciencedaily.com/releases/2005/12/051201081408.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins