Featured Research

from universities, journals, and other organizations

Endotoxins In House Dust Pose A Significant Risk For Asthma

Date:
December 1, 2005
Source:
American Thoracic Society
Summary:
Exposure to household endotoxin levels poses a significant risk for asthma, according to the first nationwide sampling of house dust.

Exposure to household endotoxin levels poses a significant risk for asthma, according to the first nationwide sampling of house dust.

The study appears in the first issue for December 2005 of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

Endotoxins are toxic substances associated with the outer membrane of certain gram-negative bacteria. These molecules are bound to the bacterial cell wall and are released when the bacterium ruptures or disintegrates. According to the authors, inhalation exposure to endotoxins is common in homes. Indoor sources include: dust, pets, humidifiers, pests, and outdoor air.

Past studies have shown that exposure can cause lung inflammation.

Peter S. Thorne, Ph.D., of the Environmental Health Sciences Research Center at the University of Iowa, Iowa City, and five associates, evaluated 2,456 residents in 831 homes selected to represent the demographic characteristics of the U.S. population. The investigators took 2,552 house dust samples from five locations within the homes, including bedroom floors, bedding, family room floors, sofa surfaces, and kitchen floors.

"This study clearly demonstrates significant relationships between household endotoxin and diagnosed asthma, recent asthma symptoms, current use of asthma medications, and wheezing," said Dr. Thorne. "No effect was observed of allergy status on the relationship between endotoxin and asthma outcomes. This suggests that current endotoxin exposure may have little impact on allergy status and that airway inflammation is the most significant effect of endotoxin exposure in a cross-section of the population."

The authors found the strongest relationship between asthma, asthma medications, and wheezing came from endotoxin levels in bedroom floor and bedding dust. However, the effects were observed only in adults and not in children.

Moreover, the investigators also noted that the endotoxin concentrations were highest in kitchen and living room floor dust, and lowest for bedding (including mattress and pillow).

"The mean concentration of endotoxin in the kitchen floor dust was 2.3-fold higher than bedroom floor dust and 4.3-fold higher than bedding dust," said Dr. Thorne.

Two field workers visited each household and took answers from residents to detailed questionnaires, conducted a home inspection, and vacuumed dust into an in-line filter.

The study yielded an 11.3 percent prevalence rate for diagnosed asthma among the homes surveyed. This figure compared favorably with the 11.1 percent prevalence rate of diagnosed asthma associated with the 2002 National Health Interview Survey.

The authors also noted that their national survey demonstrated that U.S. household endotoxin exposure levels were higher than those in Europe.



Story Source:

The above story is based on materials provided by American Thoracic Society. Note: Materials may be edited for content and length.


Cite This Page:

American Thoracic Society. "Endotoxins In House Dust Pose A Significant Risk For Asthma." ScienceDaily. ScienceDaily, 1 December 2005. <www.sciencedaily.com/releases/2005/12/051201081408.htm>.
American Thoracic Society. (2005, December 1). Endotoxins In House Dust Pose A Significant Risk For Asthma. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2005/12/051201081408.htm
American Thoracic Society. "Endotoxins In House Dust Pose A Significant Risk For Asthma." ScienceDaily. www.sciencedaily.com/releases/2005/12/051201081408.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins