Featured Research

from universities, journals, and other organizations

Gene Increases Risk Of Tuberculosis

Date:
December 13, 2005
Source:
Journal of Experimental Medicine
Summary:
A study in the December 19 issue of The Journal of Experimental Medicine identifies a small genetic change that increases the odds of developing active tuberculosis (TB). Pedro Flores-Villanueva and his colleagues at the University of Texas Health Center (Tyler, TX) studied groups of patients in Mexico and Korea and found that individuals who carry this genetic change were more likely to develop disease when infected with TB-causing bacteria.

A study in the December 19 issue of The Journal of Experimental Medicine identifies a small genetic change that increases the odds of developing active tuberculosis (TB). Pedro Flores-Villanueva and his colleagues at the University of Texas Health Center (Tyler, TX) studied groups of patients in Mexico and Korea and found that individuals who carry this genetic change were more likely to develop disease when infected with TB-causing bacteria.

Infections with Mycobacterium tuberculosis, the bacterium that causes TB, are on the rise, with an estimated eight million new infections and two million TB-induced deaths occurring annually. But not all people who are exposed to this bug become ill -- a phenomenon largely explained by genetic differences that make some individuals more prone to developing disease than others. Indeed, a recent scientific study found that a particular region on the human chromosome 17 was associated with increased risk of developing active tuberculosis, but the exact gene(s) responsible for this effect was not identified.

Flores-Villanueva and colleagues show that the culprit behind the increased susceptibility to TB was a small change in the gene that encodes a protein called MCP-1 (the MCP-1 gene resides of chromosome 17). The genetic change was a tiny one, with the DNA sequence differing by only a single nucleotide (the building blocks of DNA). This change, which resulted in increased production of the MCP-1 protein, was five times more prevalent in individuals with active TB than in those who were infected but remained healthy.

MCP-1 is a protein that helps attract immune cells to sites of infection. For this reason, this protein is important during the early immune response to TB-causing bacteria. But extremely high levels of MCP-1 can be dangerous, as they inhibit the production of another immune protein called interleukin-12. Interleukin-12 is required to activate the immune cells that fight off the infection once they arrive on the scene. In an accompanying commentary article, geneticists Alexandre Alcais, Jean-Laurent Casanova and their colleagues at the University of Paris note that this is the largest genetic impact on adult TB that has ever been described.



Story Source:

The above story is based on materials provided by Journal of Experimental Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Experimental Medicine. "Gene Increases Risk Of Tuberculosis." ScienceDaily. ScienceDaily, 13 December 2005. <www.sciencedaily.com/releases/2005/12/051213074213.htm>.
Journal of Experimental Medicine. (2005, December 13). Gene Increases Risk Of Tuberculosis. ScienceDaily. Retrieved April 21, 2014 from www.sciencedaily.com/releases/2005/12/051213074213.htm
Journal of Experimental Medicine. "Gene Increases Risk Of Tuberculosis." ScienceDaily. www.sciencedaily.com/releases/2005/12/051213074213.htm (accessed April 21, 2014).

Share This



More Health & Medicine News

Monday, April 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Breakfast Foods Are Getting Pricier

Breakfast Foods Are Getting Pricier

AP (Apr. 21, 2014) Breakfast is now being served with a side of sticker shock. The cost of morning staples like bacon, coffee and orange juice is on the rise because of global supply problems. (April 21) Video provided by AP
Powered by NewsLook.com
Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins