Featured Research

from universities, journals, and other organizations

Gene Increases Risk Of Tuberculosis

Date:
December 13, 2005
Source:
Journal of Experimental Medicine
Summary:
A study in the December 19 issue of The Journal of Experimental Medicine identifies a small genetic change that increases the odds of developing active tuberculosis (TB). Pedro Flores-Villanueva and his colleagues at the University of Texas Health Center (Tyler, TX) studied groups of patients in Mexico and Korea and found that individuals who carry this genetic change were more likely to develop disease when infected with TB-causing bacteria.

A study in the December 19 issue of The Journal of Experimental Medicine identifies a small genetic change that increases the odds of developing active tuberculosis (TB). Pedro Flores-Villanueva and his colleagues at the University of Texas Health Center (Tyler, TX) studied groups of patients in Mexico and Korea and found that individuals who carry this genetic change were more likely to develop disease when infected with TB-causing bacteria.

Infections with Mycobacterium tuberculosis, the bacterium that causes TB, are on the rise, with an estimated eight million new infections and two million TB-induced deaths occurring annually. But not all people who are exposed to this bug become ill -- a phenomenon largely explained by genetic differences that make some individuals more prone to developing disease than others. Indeed, a recent scientific study found that a particular region on the human chromosome 17 was associated with increased risk of developing active tuberculosis, but the exact gene(s) responsible for this effect was not identified.

Flores-Villanueva and colleagues show that the culprit behind the increased susceptibility to TB was a small change in the gene that encodes a protein called MCP-1 (the MCP-1 gene resides of chromosome 17). The genetic change was a tiny one, with the DNA sequence differing by only a single nucleotide (the building blocks of DNA). This change, which resulted in increased production of the MCP-1 protein, was five times more prevalent in individuals with active TB than in those who were infected but remained healthy.

MCP-1 is a protein that helps attract immune cells to sites of infection. For this reason, this protein is important during the early immune response to TB-causing bacteria. But extremely high levels of MCP-1 can be dangerous, as they inhibit the production of another immune protein called interleukin-12. Interleukin-12 is required to activate the immune cells that fight off the infection once they arrive on the scene. In an accompanying commentary article, geneticists Alexandre Alcais, Jean-Laurent Casanova and their colleagues at the University of Paris note that this is the largest genetic impact on adult TB that has ever been described.



Story Source:

The above story is based on materials provided by Journal of Experimental Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Experimental Medicine. "Gene Increases Risk Of Tuberculosis." ScienceDaily. ScienceDaily, 13 December 2005. <www.sciencedaily.com/releases/2005/12/051213074213.htm>.
Journal of Experimental Medicine. (2005, December 13). Gene Increases Risk Of Tuberculosis. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2005/12/051213074213.htm
Journal of Experimental Medicine. "Gene Increases Risk Of Tuberculosis." ScienceDaily. www.sciencedaily.com/releases/2005/12/051213074213.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins