Featured Research

from universities, journals, and other organizations

Drug Cuts Sleep Apnea In Heart Failure Patients

Date:
January 15, 2006
Source:
American Thoracic Society
Summary:
Since sleep apnea is associated with heart failure, patients who take a single dose of acetazolamide -- a mild diurectic and respiratory stimulant -- before going to bed exhibit less sleep apnea, improved oxygen levels and fewer daytime symptoms of sleepiness.

Since sleep apnea is associated with heart failure, patients who take a single dose of acetazolamide--a mild diuretic and respiratory stimulant--before going to bed exhibit less sleep apnea, improved blood oxygen levels and fewer daytime symptoms of sleepiness.

The results of the double-blind, placebo-controlled study appear in the second issue for January 2006 of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

Shahrokh Javaheri, M.D., of the Pulmonary Service in the Department of Veterans Affairs Medical Center and Department of Medicine at the University of Cincinnati College of Medicine in Cincinnati, Ohio, studied 12 male patients with stable heart failure who had more than 15 episodes per hour each night of sleep apnea (breathing pauses during sleep lasting 10 seconds or more.)

In heart failure, the quantity of blood pumped each minute by the heart is insufficient to meet the body's requirements for oxygen and nutrients.

In the past, acetazolamide's principal use has been to help treat breathing irregularities and sleep apneas occurring at high altitude.

According to the authors, the 12 patients with stable heart failure were randomized to a double-blind cross-over protocol with either acetazolamide or placebo, taken one hour before bedtime over the course of six nights. There was a two-week washout period between the two study segments--acetazolamide and placebo.

"An important finding of the double-blind study was the significant improvement in patient perception of improved sleep quality, waking up more refreshed, with less daytime fatigue and sleepiness while taking acetazolamide, compared with placebo," said Dr. Javaheri.

The average age of the patients was 66. There were no significant patient differences in body mass index levels, blood pressure or heart rate during the two phases of the study.

Each patient underwent a sleep test, an analysis of blood gases as well as a pH study (a test of acidity or alkalinity), a measurement of serum electrolytes, a pulmonary function test, plus other measurements at the start of the study and at the completion of each arm (acetazolamide and placebo).

"We hypothesize that with long-term drug therapy, as sleep-related breathing disorders improve, it may be reflected in an improvement in cardiac function that will further improve periodic breathing, resulting in a positive feedback cycle," said Dr. Javaheri. "Improvement in sleep apnea may assist cardiac function by a variety of mechanisms such as improved oxygenation."

The author points out that since the short-term efficacy of the drug has been documented, more long-term studies are needed to measure patient cardiac function, quality of life and the levels of norepinephrine in the plasma and urine. (Norepinephrine is a hormone used to maintain blood pressure and to treat cardiac arrest.)

###

For more information on sleep apnea, visit the American Sleep Apnea Association's website at http://www.sleepapnea.org/. A member of the American Thoracic Society's Public Advisory Roundtable, the Association offers a variety of material on disease diagnosis, treatment and management, as well as advocacy for more research.


Story Source:

The above story is based on materials provided by American Thoracic Society. Note: Materials may be edited for content and length.


Cite This Page:

American Thoracic Society. "Drug Cuts Sleep Apnea In Heart Failure Patients." ScienceDaily. ScienceDaily, 15 January 2006. <www.sciencedaily.com/releases/2006/01/060115154048.htm>.
American Thoracic Society. (2006, January 15). Drug Cuts Sleep Apnea In Heart Failure Patients. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2006/01/060115154048.htm
American Thoracic Society. "Drug Cuts Sleep Apnea In Heart Failure Patients." ScienceDaily. www.sciencedaily.com/releases/2006/01/060115154048.htm (accessed August 20, 2014).

Share This




More Health & Medicine News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com
101-Year-Old Working Man Has All The Advice You Need

101-Year-Old Working Man Has All The Advice You Need

Newsy (Aug. 19, 2014) Herman Goldman has worked at the same lighting store for almost 75 years. Find out his secrets to a happy, productive life. Video provided by Newsy
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins