Featured Research

from universities, journals, and other organizations

Drug Cuts Sleep Apnea In Heart Failure Patients

Date:
January 15, 2006
Source:
American Thoracic Society
Summary:
Since sleep apnea is associated with heart failure, patients who take a single dose of acetazolamide -- a mild diurectic and respiratory stimulant -- before going to bed exhibit less sleep apnea, improved oxygen levels and fewer daytime symptoms of sleepiness.

Since sleep apnea is associated with heart failure, patients who take a single dose of acetazolamide--a mild diuretic and respiratory stimulant--before going to bed exhibit less sleep apnea, improved blood oxygen levels and fewer daytime symptoms of sleepiness.

The results of the double-blind, placebo-controlled study appear in the second issue for January 2006 of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

Shahrokh Javaheri, M.D., of the Pulmonary Service in the Department of Veterans Affairs Medical Center and Department of Medicine at the University of Cincinnati College of Medicine in Cincinnati, Ohio, studied 12 male patients with stable heart failure who had more than 15 episodes per hour each night of sleep apnea (breathing pauses during sleep lasting 10 seconds or more.)

In heart failure, the quantity of blood pumped each minute by the heart is insufficient to meet the body's requirements for oxygen and nutrients.

In the past, acetazolamide's principal use has been to help treat breathing irregularities and sleep apneas occurring at high altitude.

According to the authors, the 12 patients with stable heart failure were randomized to a double-blind cross-over protocol with either acetazolamide or placebo, taken one hour before bedtime over the course of six nights. There was a two-week washout period between the two study segments--acetazolamide and placebo.

"An important finding of the double-blind study was the significant improvement in patient perception of improved sleep quality, waking up more refreshed, with less daytime fatigue and sleepiness while taking acetazolamide, compared with placebo," said Dr. Javaheri.

The average age of the patients was 66. There were no significant patient differences in body mass index levels, blood pressure or heart rate during the two phases of the study.

Each patient underwent a sleep test, an analysis of blood gases as well as a pH study (a test of acidity or alkalinity), a measurement of serum electrolytes, a pulmonary function test, plus other measurements at the start of the study and at the completion of each arm (acetazolamide and placebo).

"We hypothesize that with long-term drug therapy, as sleep-related breathing disorders improve, it may be reflected in an improvement in cardiac function that will further improve periodic breathing, resulting in a positive feedback cycle," said Dr. Javaheri. "Improvement in sleep apnea may assist cardiac function by a variety of mechanisms such as improved oxygenation."

The author points out that since the short-term efficacy of the drug has been documented, more long-term studies are needed to measure patient cardiac function, quality of life and the levels of norepinephrine in the plasma and urine. (Norepinephrine is a hormone used to maintain blood pressure and to treat cardiac arrest.)

###

For more information on sleep apnea, visit the American Sleep Apnea Association's website at http://www.sleepapnea.org/. A member of the American Thoracic Society's Public Advisory Roundtable, the Association offers a variety of material on disease diagnosis, treatment and management, as well as advocacy for more research.


Story Source:

The above story is based on materials provided by American Thoracic Society. Note: Materials may be edited for content and length.


Cite This Page:

American Thoracic Society. "Drug Cuts Sleep Apnea In Heart Failure Patients." ScienceDaily. ScienceDaily, 15 January 2006. <www.sciencedaily.com/releases/2006/01/060115154048.htm>.
American Thoracic Society. (2006, January 15). Drug Cuts Sleep Apnea In Heart Failure Patients. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2006/01/060115154048.htm
American Thoracic Society. "Drug Cuts Sleep Apnea In Heart Failure Patients." ScienceDaily. www.sciencedaily.com/releases/2006/01/060115154048.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com
How The 'Angelina Jolie Effect' Increased Cancer Screenings

How The 'Angelina Jolie Effect' Increased Cancer Screenings

Newsy (Sep. 19, 2014) Angelina's Jolie's decision to undergo a preventative mastectomy in 2013 inspired many women to seek early screenings for the disease. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins