Featured Research

from universities, journals, and other organizations

Metabolic Acidosis Associated With An Increased Mortality Rate

Date:
February 11, 2006
Source:
BioMed Central
Summary:
Critically ill patients with metabolic acidosis are twice as likely to die as patients who do not have metabolic acidosis. A study published today in the journal Critical Care shows that the mortality rate among patients with metabolic acidosis is highest for patients with lactic acidosis.

Critically ill patients with metabolic acidosis are twice as likely to die as patients who do not have metabolic acidosis. A study published today in the journal Critical Care shows that the mortality rate among patients with metabolic acidosis is highest for patients with lactic acidosis -- abnormally acidic blood pH due to an excess of lactate - but it is also considerable for patients with strong ion gap (SIG) acidosis -- acidosis due to an excess of unidentified ions. Both lactate and SIG should be carefully monitored in intensive care units (ICUs).

In the largest study of its kind, Kyle Gunnerson from Virginia Commonwealth University, Virginia, USA and colleagues from the University of Pittsburgh, Pennsylvania, USA, selected patients admitted to the University of Pittsburgh Medical Center ICUs who were suspected of having metabolic acidosis. Out of 851 patients screened, 548 patients had metabolic acidosis and 303 patients did not. The patients who did not were used as the control, non-acidosis group.

Among patients with metabolic acidosis, 44% of patients had lactic acidosis, 37% of patients had SIG acidosis and 19% had hyperchloremic acidosis (acidosis not associated with either lactate or SIG). The mortality rate was 45% for patients with metabolic acidosis compared with 26% for patients without. Patients with lactic acidosis had a mortality rate of 56% and for patients with SIG acidosis, the mortality rate was 39%. Patients with hyperchloremic acidosis had a mortality rate similar to the rate in the non-acidosis group: 29%.

A statistical analysis confirmed that both lactate and SIG were strong independent predictors of hospital mortality. The authors recommend that both should be monitored in critically ill patients.

###

Article:
Critical Care Manuscript: C50806P
Lactate vs. Non-Lactate Metabolic Acidosis: A Retrospective Outcome Evaluation of Critically Ill Patients
Kyle J Gunnerson, Melissa Saul, Shui He and John A Kellum
Critical Care 2006, 10:R22 (10 February 2006) doi:10.1186/cc3987

After the embargo, article available at: http://ccforum.com/content/10/1/R22


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central. "Metabolic Acidosis Associated With An Increased Mortality Rate." ScienceDaily. ScienceDaily, 11 February 2006. <www.sciencedaily.com/releases/2006/02/060211134839.htm>.
BioMed Central. (2006, February 11). Metabolic Acidosis Associated With An Increased Mortality Rate. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2006/02/060211134839.htm
BioMed Central. "Metabolic Acidosis Associated With An Increased Mortality Rate." ScienceDaily. www.sciencedaily.com/releases/2006/02/060211134839.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins