Featured Research

from universities, journals, and other organizations

Metabolic Acidosis Associated With An Increased Mortality Rate

Date:
February 11, 2006
Source:
BioMed Central
Summary:
Critically ill patients with metabolic acidosis are twice as likely to die as patients who do not have metabolic acidosis. A study published today in the journal Critical Care shows that the mortality rate among patients with metabolic acidosis is highest for patients with lactic acidosis.

Critically ill patients with metabolic acidosis are twice as likely to die as patients who do not have metabolic acidosis. A study published today in the journal Critical Care shows that the mortality rate among patients with metabolic acidosis is highest for patients with lactic acidosis -- abnormally acidic blood pH due to an excess of lactate - but it is also considerable for patients with strong ion gap (SIG) acidosis -- acidosis due to an excess of unidentified ions. Both lactate and SIG should be carefully monitored in intensive care units (ICUs).

In the largest study of its kind, Kyle Gunnerson from Virginia Commonwealth University, Virginia, USA and colleagues from the University of Pittsburgh, Pennsylvania, USA, selected patients admitted to the University of Pittsburgh Medical Center ICUs who were suspected of having metabolic acidosis. Out of 851 patients screened, 548 patients had metabolic acidosis and 303 patients did not. The patients who did not were used as the control, non-acidosis group.

Among patients with metabolic acidosis, 44% of patients had lactic acidosis, 37% of patients had SIG acidosis and 19% had hyperchloremic acidosis (acidosis not associated with either lactate or SIG). The mortality rate was 45% for patients with metabolic acidosis compared with 26% for patients without. Patients with lactic acidosis had a mortality rate of 56% and for patients with SIG acidosis, the mortality rate was 39%. Patients with hyperchloremic acidosis had a mortality rate similar to the rate in the non-acidosis group: 29%.

A statistical analysis confirmed that both lactate and SIG were strong independent predictors of hospital mortality. The authors recommend that both should be monitored in critically ill patients.

###

Article:
Critical Care Manuscript: C50806P
Lactate vs. Non-Lactate Metabolic Acidosis: A Retrospective Outcome Evaluation of Critically Ill Patients
Kyle J Gunnerson, Melissa Saul, Shui He and John A Kellum
Critical Care 2006, 10:R22 (10 February 2006) doi:10.1186/cc3987

After the embargo, article available at: http://ccforum.com/content/10/1/R22


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central. "Metabolic Acidosis Associated With An Increased Mortality Rate." ScienceDaily. ScienceDaily, 11 February 2006. <www.sciencedaily.com/releases/2006/02/060211134839.htm>.
BioMed Central. (2006, February 11). Metabolic Acidosis Associated With An Increased Mortality Rate. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2006/02/060211134839.htm
BioMed Central. "Metabolic Acidosis Associated With An Increased Mortality Rate." ScienceDaily. www.sciencedaily.com/releases/2006/02/060211134839.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins