Featured Research

from universities, journals, and other organizations

Androgen Deprivation Therapy Does Not Keep Localized Prostate Cancer From Spreading, New Study Says

Date:
February 27, 2006
Source:
Oregon Health & Science University
Summary:
Oregon Health & Science University Cancer Institute researchers wanted to know if depriving men of testosterone actually keeps cancer from spreading beyond the prostate. What they found is that men who have localized prostate cancer with certain high-risk features and receive this treatment -- known as androgen deprivation therapy -- remain at risk of dying from prostate cancer.

Oregon Health & Science University Cancer Institute researchers wanted to know if depriving men of testosterone actually keeps cancer from spreading beyond the prostate. What they found is that men who have localized prostate cancer with certain high-risk features and receive this treatment -- known as androgen deprivation therapy -- remain at risk of dying from prostate cancer.

Related Articles


"The notion that androgen deprivation therapy will hold prostate cancer at bay while you die of something else is not proving to be entirely true," said Tomasz Beer, M.D., director of the Prostate Cancer Research Program in the Oregon Health & Science University Cancer Institute.

This is especially important because recent studies of physician practice trends show that androgen deprivation therapy is being used with increased frequency for men with prostate cancer that has not spread.

"Reasons for this trend are not really known, but may include a desire to do something rather than do nothing on the part of both physicians and patients," Beer said. "Unfortunately, these men may be enduring significant side effects for an uncertain benefit."

Androgen deprivation therapy, also known as hormone therapy, is the gold standard of care for men whose prostate cancer is advanced and has spread throughout the body. The therapy works by shutting down male hormones, principally testosterone, that can promote prostate cancer growth. This common treatment for prostate cancer wipes out most male hormones found in the body. Side effects can be significant and include erectile dysfunction, hot flashes, fatigue, osteoporosis, high cholesterol, anemia, forgetfulness and insomnia.

Little is known about the effectiveness of hormonal therapy in men whose cancer remains localized within the prostate, so Beer and his colleagues decided to study data from the Prostate Cancer Outcome Study (PCOS). They presented their results on Saturday, Feb. 25, at the Prostate Cancer Symposium in San Francisco.

In the retrospective study, the research team examined demographic data, socio-economic factors and tumor biology in relationship to overall survival and cancer-specific survival for a subgroup of 276 PCOS subjects who had localized prostate cancer and received androgen deprivation therapy as their primary treatment. Between 1994 and 1995, a total of 3,486 men were enrolled in PCOS within six months of prostate cancer diagnosis.

The analysis showed that out all the demographic and socio-economic factors considered, overall survival was predicted only by age and certain features of prostate cancer. Tumor biology, which is measured by Gleason score, was the only independent predictor of cancer specific survival. Tumor mass as measured by PSA approached statistical significance as a predictor. Nearly 10 percent of men died from prostate cancer within 5 years of starting hormonal therapy.

"Our study indicates that cancer remains an important contributor to overall mortality in these men, particularly those with high Gleason score and high serum PSA," Beer said. "These data will be useful for men with localized prostate cancer choosing between aggressive treatments such as surgery or radiation, observation and androgen deprivation therapy."

In an earlier OHSU Cancer Institute study of the effectiveness of hormone deprivation as a primary therapy for localized prostate cancer, researchers found that younger men and those with higher-grade tumors are more likely to experience disease progression during treatment. They also found that men with localized prostate cancer on hormone therapy experience a higher than expected rate of bone fractures caused primarily by treatment-related osteoporosis.

"Studies suggest that more needs to be known about the risks and benefits of this treatment before we recommend it to patients with localized disease," Beer said.

Prostate cancer is the most common cancer in men and the second leading cause of cancer-related death in American men. Overall, 1 in 6 men will develop prostate cancer during his lifetime.

###

This study was funded by the National Cancer Institute, a component of the National Institutes of Health.

Particulars:
Abstract No. 291: Predictors of Overall and Cancer-Specific Survival in Patients with Clinically Localized Prostate Cancer (PC) Treated with Primary Androgen Deprivation Therapy (PADT): Results from the Prostate Cancer Outcomes Study.

Authors: Julie N. Graff, Motomi Mori, Hong Li, Mark Garzotto, David Penson, Arnold Potosky and Tomasz M. Beer.


Story Source:

The above story is based on materials provided by Oregon Health & Science University. Note: Materials may be edited for content and length.


Cite This Page:

Oregon Health & Science University. "Androgen Deprivation Therapy Does Not Keep Localized Prostate Cancer From Spreading, New Study Says." ScienceDaily. ScienceDaily, 27 February 2006. <www.sciencedaily.com/releases/2006/02/060226114317.htm>.
Oregon Health & Science University. (2006, February 27). Androgen Deprivation Therapy Does Not Keep Localized Prostate Cancer From Spreading, New Study Says. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2006/02/060226114317.htm
Oregon Health & Science University. "Androgen Deprivation Therapy Does Not Keep Localized Prostate Cancer From Spreading, New Study Says." ScienceDaily. www.sciencedaily.com/releases/2006/02/060226114317.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins