Featured Research

from universities, journals, and other organizations

Sweetgum Tree Could Help Lessen Shortage Of Bird Flu Drug

Date:
April 5, 2006
Source:
American Chemical Society
Summary:
Chemists have found that the seeds of the sweetgum fruit -- also called "gumballs" -- contain significant amounts of shikimic acid, the starting material used to produce the main antiviral agent in a much-heralded drug for fighting bird flu. The finding could help increase the global supply of the drug, which is now in short supply, they say. Their study will be presented March 29th in Atlanta at the national meeting of the American Chemical Society.

The sweetgum tree grows widely throughout the country and is known for its mace-like green fruit, which are sometimes called "gumballs." Now, this spiny fruit may become an important source of a chemical needed to make a lifesaving drug against bird flu — a drug that is currently in short supply worldwide, researchers say.

Chemists have found that the seeds of the sweetgum fruit contain significant amounts of shikimic acid, the starting material used to produce the main antiviral agent in a much-heralded drug for fighting bird flu. Their findings, which could help increase the global supply of the drug, were described today at the 231st national meeting of the American Chemical Society, the world’s largest scientific society.

Shikimic acid is used to make a generic drug called oseltamivir — best known commercially as Tamiflu® — which is used to fight many types of flu viruses. Some health experts believe that this and similar antiviral drugs could help save lives by slowing the spread of the virus in the absence of a bird flu vaccine, which is still in development.

The drug, which blocks the replication of the flu virus, is being stockpiled worldwide to slow or stop a possible bird flu pandemic that some experts predict could kill millions — if the virus mutates into a form that can spread from person to person. The virus, a strain known as H5N1, primarily afflicts birds at present but has been known to kill a small but growing number of humans who have had close contact with infected birds.

There is a skyrocketing demand for Tamiflu, but some experts fear there won’t be enough of the drug to treat everyone if a worldwide pandemic occurs. The supply problem resides in the drug’s source: The shikimic acid used to make it is obtained almost exclusively from the Chinese star anise, a fruit that is found mainly in China and whose supply has dwindled due to high demand for the flu drug. Although shikimic acid is found in many plants, star anise has been considered the most abundant plant source, until now.

"Our work gives the hearty sweetgum tree another purpose, one that may help to alleviate the worldwide shortage of shikimic acid," says study leader Thomas Poon, Ph.D., a professor of chemistry from the W.M. Keck Science Center at The Claremont Colleges in Claremont, Calif. "They have lots of potential for fighting bird flu."

The sweetgum tree grows widely throughout the United States and other parts of the world. In this country, it is particularly common in the South, including the Carolinas, Georgia and Alabama, but also can be found as far west as Missouri, Arkansas and Oklahoma and northward in parts of Illinois.

Although shikimic acid is found in the leaves and bark of the tree, it is most abundant in the fruit, Poon says. In the mature tree, the fruit emerges as a green seedpod that later dries into a brown, spiny husk, which releases an abundance of tiny, grain-like seeds. To optimize shikimic acid extraction, the gumballs need to be harvested when they are still green and before the seeds have been dispersed, Poon says. Each tree can hold hundreds, if not thousands, of seedpods.

The American Chemical Society — the world’s largest scientific society — is a nonprofit organization chartered by the U.S. Congress and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Cite This Page:

American Chemical Society. "Sweetgum Tree Could Help Lessen Shortage Of Bird Flu Drug." ScienceDaily. ScienceDaily, 5 April 2006. <www.sciencedaily.com/releases/2006/04/060405234139.htm>.
American Chemical Society. (2006, April 5). Sweetgum Tree Could Help Lessen Shortage Of Bird Flu Drug. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2006/04/060405234139.htm
American Chemical Society. "Sweetgum Tree Could Help Lessen Shortage Of Bird Flu Drug." ScienceDaily. www.sciencedaily.com/releases/2006/04/060405234139.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) — The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) — Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) — America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) — China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins