Featured Research

from universities, journals, and other organizations

Hormone Found To Decrease Appetite And Increase Activity

Date:
April 26, 2006
Source:
Imperial College London
Summary:
New research shows how topping up the levels of a hormone found in the gut could help reduce the appetite and increase activity in overweight and obese people.

New research shows how topping up the levels of a hormone found in the gut could help reduce the appetite and increase activity in overweight and obese people.

The study now being pre-published online in the International Journal of Obesity shows how the team from Imperial College London gave injections of oxyntomodulin to fifteen overweight but healthy volunteers from Hammersmith Hospital, and monitored how this affected their food intake, and levels of activity.

Professor Steve Bloom, from Imperial College London, who led the research, said: "The discovery that this hormone has a double effect, increasing energy expenditure as well as reducing food intake, could be of huge importance. When most people diet, this produces a reduction in activity, which is probably an adaptive trait to conserve energy during times of famine. However this does make it especially difficult for obese individuals trying to loose weight. In contrast oxyntomodulin decreases calorific intake, but actually increases energy expenditure, making it an ideal intervention for the obese."

The researchers used fifteen healthy overweight male and female volunteers, aged between 23 and 49 years. The volunteers completed three separate four-day study sessions, where they self administered either saline or oxyntomodulin according to a double blind randomised trial.

After the first injection, the volunteers were given a meal, and their calorific intake was monitored. They spent the next two days in their normal environment, self administering oxyntomodulin three times a day before meals. On the fourth day, the volunteers came back to the hospital to have their energy expenditure measured.

They found that after the first meal, the volunteers ate on average 128 kcal or 17.4 percent less, while activity related energy expenditure increased by an average of 143 kcal or 26.2 percent.

The researchers also found a reduction in body weight by an average of 0.5 percent.

Professor Bloom added: "This discovery could provide doctors with a whole new way to treat the current obesity epidemic. We need to get away from the focus on food and start to think about how to increase exercise. The question is how to make people enjoy taking exercise and how to encourage them to do it spontaneously.

"Oxyntomodulin could work by letting the brain know it has an adequate energy supply and that it can afford to do productive things rather than concentrate solely on food seeking or conserving energy. It signals to the brain that it can increase exercise by letting it know that the energy is available to do more things.

"If used as a therapy for obesity, oxyntomodulin provides a double whammy - reducing food intake and increasing spontaneous activity."


Story Source:

The above story is based on materials provided by Imperial College London. Note: Materials may be edited for content and length.


Cite This Page:

Imperial College London. "Hormone Found To Decrease Appetite And Increase Activity." ScienceDaily. ScienceDaily, 26 April 2006. <www.sciencedaily.com/releases/2006/04/060426184212.htm>.
Imperial College London. (2006, April 26). Hormone Found To Decrease Appetite And Increase Activity. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2006/04/060426184212.htm
Imperial College London. "Hormone Found To Decrease Appetite And Increase Activity." ScienceDaily. www.sciencedaily.com/releases/2006/04/060426184212.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins