Featured Research

from universities, journals, and other organizations

How Drug Binds To Neurons To Stop Drunken Symptoms Of Alcohol

Date:
May 10, 2006
Source:
University of California - Los Angeles
Summary:
UCLA researchers have discovered how an alcohol antidote drug binds to specific receptors on neurons to stop the drunken behavioral symptoms of alcohol. Identifying which receptors the drug binds to may lead to a better understanding of how alcohol works in the brain, and help develop alcohol addiction medications and treatments.

UCLA researchers discovered how an experimental drug, called Ro15-4513, binds to specific receptors on brain neurons, which helps explain how this drug stops the drunken behavioral symptoms of alcohol such as impaired motor coordination, memory loss and drowsiness.

The team showed in the lab that Ro15-4513 binds to and blocks alcohol action on these highly alcohol-sensitive receptors. The UCLA group previously found that these receptors are specific subtypes of Gamma-amino butyric acid (GABA-A) receptors that play a role in impairing motor coordination caused by alcohol in experimental animals.

These studies are the first to show how the alcohol antidote drug Ro15-4513 binds to these GABA-A receptors. The research may lead to a better understanding of how alcohol works in the brain as well as help develop drugs that prevent alcohol actions such as a sober-up pill, and alcohol addiction medications and treatments. UCLA researchers also suggest in the future that it may be possible to harness the beneficial effects of alcohol on the body, including inducing sleep, enhancing mood or mirroring the positive effects of moderate alcohol consumption on the heart and brain.

Authors of the study include Richard W. Olsen, Ph.D., professor and Martin Wallner, Ph.D., researcher, both in the UCLA Department of Molecular and Medical Pharmacology. The research appears in the May 8 online edition of the Proceedings of the National Academy of Sciences.

The study was funded by the National Institutes of Health, the Alcoholic Beverage Medical Research Foundation, and the State of California for medical research on alcohol and substance abuse.


Story Source:

The above story is based on materials provided by University of California - Los Angeles. Note: Materials may be edited for content and length.


Cite This Page:

University of California - Los Angeles. "How Drug Binds To Neurons To Stop Drunken Symptoms Of Alcohol." ScienceDaily. ScienceDaily, 10 May 2006. <www.sciencedaily.com/releases/2006/05/060510192138.htm>.
University of California - Los Angeles. (2006, May 10). How Drug Binds To Neurons To Stop Drunken Symptoms Of Alcohol. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2006/05/060510192138.htm
University of California - Los Angeles. "How Drug Binds To Neurons To Stop Drunken Symptoms Of Alcohol." ScienceDaily. www.sciencedaily.com/releases/2006/05/060510192138.htm (accessed July 23, 2014).

Share This




More Mind & Brain News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Do Obese Women Have 'Food Learning Impairment'?

Do Obese Women Have 'Food Learning Impairment'?

Newsy (July 18, 2014) Yale researchers tested 135 men and women, and it was only obese women who were deemed to have "impaired associative learning." Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins