Featured Research

from universities, journals, and other organizations

Selenium-protein Deficiency Raises Prostate Cancer Risk

Date:
May 23, 2006
Source:
University of Illinois at Chicago
Summary:
UIC researchers report new findings that suggest the level of selenium-containing proteins in the body plays an instrumental role in preventing cancer, and that dietary selenium plays a role in stimulating the body's level of these proteins.

Selenium, an essential dietary mineral that can act as an antioxidant when incorporated into proteins, has been shown in many studies to reduce the incidence of cancers -- notably lung, colorectal and prostate.

"The problem is, nobody seems to know how the mechanism works, and that's not trivial," said Alan Diamond, professor of human nutrition at the University of Illinois at Chicago and principal investigator in an ongoing multidisciplinary study set up at UIC to help answer that question.

"Knowing how it works allows you to maximize-out its benefits," he said.

Diamond and his colleagues report in the May 23 issue of the Proceedings of the National Academy of Sciences on research findings using specially bred transgenic mice that suggest it is the level of selenium-containing proteins in the body that is instrumental in preventing cancer, and that dietary selenium plays a role in stimulating the body's level of these selenoproteins.

Two genetically manipulated mice were mated. One was prone to developing prostate cancer. The other had lower levels of selenoproteins. Approximately 50 offspring that carried both traits were studied to see if the reduced levels of selenoproteins accelerated cancer development. As the researchers suspected, it did.

"It's a hardcore link in an animal model system of selenium-containing proteins to prostate cancer and, by extrapolation, the mechanism by which selenium prevents cancer," said Diamond.

Further research is underway to corroborate the stimulating effect of dietary selenium in enhancing levels of protective selenoproteins. Diamond added that much work remains to be done to discover exactly how selenoproteins play their protective role, and in whom.

At least 25 different selenoproteins have been found in the human body. But what role each plays is not known, nor is it known if certain persons are genetically more -- or less -- receptive to the benefits of these proteins, or to a selenium supplement, Diamond said.

The effectiveness of selenium may be due to its effects on a single selenoprotein, or combinations of several members of this class. One selenoprotein in particular, glutathione peroxidase, is of special interest to Diamond and his associates. They plan to run new tests using new mice genetically modified to reduce levels of just this one selenoprotein.

"If reductions result in accelerated prostate cancer, then we have our player," he said.

Other UIC faculty participating in the study include Veda Diwadkar-Navsariwala, post-doctoral researcher in human nutrition; Gain Prins, professor of urology; Steven Swanson, associate professor of medicinal chemistry and pharmacognosy; Lynn Birch, research specialist in urology; Vera Ray, clinical assistant professor of pathology; Sadam Hedayat, distinguished professor of statistics; and Daniel Lantvit, research specialist in pharmaceutical sciences.


Story Source:

The above story is based on materials provided by University of Illinois at Chicago. Note: Materials may be edited for content and length.


Cite This Page:

University of Illinois at Chicago. "Selenium-protein Deficiency Raises Prostate Cancer Risk." ScienceDaily. ScienceDaily, 23 May 2006. <www.sciencedaily.com/releases/2006/05/060523072036.htm>.
University of Illinois at Chicago. (2006, May 23). Selenium-protein Deficiency Raises Prostate Cancer Risk. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2006/05/060523072036.htm
University of Illinois at Chicago. "Selenium-protein Deficiency Raises Prostate Cancer Risk." ScienceDaily. www.sciencedaily.com/releases/2006/05/060523072036.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins