Featured Research

from universities, journals, and other organizations

Study Finds Men With Enlarged Prostate Can Benefit From Botox Injections

Date:
May 28, 2006
Source:
University of Pittsburgh Medical Center
Summary:
Injecting botulinum toxin A, or Botox, into the prostate gland of men with benign prostatic hyperplasia (BPH), a condition commonly referred to as enlarged prostate, eases symptoms and improves quality of life. Thirty-one patients out of 41, or 75.6 percent, experienced a 30 percent improvement in urinary tract symptoms and quality of life. These improvements were seen up to one year in some of the patients.

When researchers at the Chang Gung University Medical College, Taiwan and the University of Pittsburgh School of Medicine injected botulinum toxin A, or Botox, into the prostate gland of men with benign prostatic hyperplasia (BPH), a condition commonly referred to as enlarged prostate, they found that it eased symptoms and improved quality of life. Their results, based on 41 men with the condition, will be presented at the annual meeting of the American Urological Association (AUA) in Atlanta and published in abstract 1436 in the AUA proceedings.

"Millions of men in the United States suffer from enlarged prostate," said Michael B. Chancellor, M.D., professor of urology and gynecology at the University of Pittsburgh School of Medicine. "It's a challenging disease to live with because it causes frequent and difficult urination. Unfortunately, common treatments also are problematic because they carry some risk of serious side effects, such as impotence. Our results are encouraging because they indicate that Botox could represent a simple, safe and effective treatment for enlarged prostate."

The patients, ranging in age from 49 to 79 years, with symptomatic BPH that did not respond to standard medical treatment, received injections of Botox directly into their prostate glands. Thirty-one patients, or 75.6 percent, experienced a 30 percent improvement in urinary tract symptoms and quality of life. These improvements were seen up to one year post-injection in some of the patients. Four out of five patients, or 80 percent, were able to completely empty their bladders within a week to one month after the injection, as the Botox caused the prostate gland to relax, putting less pressure on the urethra. Patients did not experience any significant side effects, including stress urinary incontinence or erectile dysfunction.

According to Dr. Chancellor, Botox reduces the size of the prostate gland through a cellular process called apoptosis, in which the prostate cells die in a programmed manner. This reduction in size can improve urine flow and decrease residual urine left in the bladder.

BPH is one of the most common diseases affecting men as they age. More than half of all men over the age of 60, and 80 percent by age 80, will have enlarged prostates. Forty to 50 percent will develop symptoms of BPH, which include more frequent urination, urinary tract infections, the inability to completely empty the bladder and, in severe cases, eventual damage to the bladder and kidneys.

Contributors to the study include Yao-Chi Chuang, M.D., Po-Hui Chiang, M.D., and Kaohsiung Hsien, M.D., with the Chang Gung University Medical College, Taiwan; and Naoki Yoshimura M.D., Ph.D., and Fernando de Miguel, Ph.D., with the University of Pittsburgh School of Medicine. The study is funded by a grant from Allergan.


Story Source:

The above story is based on materials provided by University of Pittsburgh Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University of Pittsburgh Medical Center. "Study Finds Men With Enlarged Prostate Can Benefit From Botox Injections." ScienceDaily. ScienceDaily, 28 May 2006. <www.sciencedaily.com/releases/2006/05/060528162115.htm>.
University of Pittsburgh Medical Center. (2006, May 28). Study Finds Men With Enlarged Prostate Can Benefit From Botox Injections. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2006/05/060528162115.htm
University of Pittsburgh Medical Center. "Study Finds Men With Enlarged Prostate Can Benefit From Botox Injections." ScienceDaily. www.sciencedaily.com/releases/2006/05/060528162115.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins