Featured Research

from universities, journals, and other organizations

Mayo Clinic Studies Find Association Between Acid Reflux And Esophageal Cancer

Date:
May 31, 2006
Source:
Mayo Clinic
Summary:
Two new Mayo Clinic studies draw attention to the risk factors and possible genetic basis for Barrett's esophagus and esophageal cancer (adenocarcinoma). These studies will be presented Monday, May 22, and Tuesday, May 23, in Los Angeles at Digestive Disease Week‚® 2006.

Two new Mayo Clinic studies draw attention to the risk factors and possible genetic basis for Barrett's esophagus and esophageal cancer (adenocarcinoma). These studies will be presented Monday, May 22, and Tuesday, May 23, in Los Angeles at Digestive Disease Week 2006.

According to G. Richard Locke III, M.D., and Yvonne Romero, M.D., Mayo Clinic gastroenterologists and co-authors of one study, the incidence of esophageal cancer is increasing at what has been called an "epidemic" rate, but the cause for this increase is uncertain. Their team studied 186 cases of esophageal and stomach cancer (adenocarcinoma) and found a significant association between esophageal cancer and gastroesophageal reflux disease, also known as acid reflux.

According to Dr. Locke, the research strengthens the understanding of the connection between acid reflux and esophageal cancer.

"But only about 5 percent of individuals who experience acid reflux will develop Barrett's esophagus," says Dr. Romero. "And once Barrett's esophagus is diagnosed, patients have a 30- to 125-fold increased risk of developing esophageal cancer."

Barrett's esophagus is a condition that occurs when acid reflux stimulates changes in the lining of the esophagus so that it resembles the lining of the intestines. Currently, the only way to identify Barrett's esophagus is by performing an endoscopy.

"Acid reflux is such a common problem that it is unrealistic to perform an endoscopic examination on everyone who experiences it," explains Dr. Locke. "Thus, in order to learn what's causing this increase in esophageal cancer, we first need to know what's causing Barrett's esophagus and whether there are any genetic risks for which acid reflux patients could be screened."

A second study, led by Dr. Romero, examined that question.

Her team discovered strong evidence for susceptibility genes in familial Barrett's esophagus and esophageal cancer (adenocarcinoma). The genetic linkage analysis was performed on 278 people in 31 families with two or more members affected by Barrett's esophagus, with or without esophageal cancer.

"Our research found areas on a chromosome that appear to be important for Barrett's esophagus and esophageal cancer -- so we're on the right path," says Dr. Romero. "Our next step is to look at 94 additional families to identify the particular genes associated with these disorders. Eventually, we'd like to develop a blood test for Barrett's esophagus to identify who has this precancerous lining early in their disease course, to ultimately prevent it from escalating into esophageal cancer."

Co-authors of these studies include Sarah Crane, M.D.; William Harmsen; Nancy Diehl; Alan Zinsmeister, Ph.D.; Joseph Melton III, M.D.; Nicholas Talley, M.D., Ph.D.; Joshua Slusser; Mariza de Andrade, Ph.D.; Julie Cunningham, Ph.D.; Teresa Zais; Debra Geno; Gloria Petersen, Ph.D., and the Barrett's Esophagus Genomic Study Group; all of Mayo Clinic in Rochester, Minn.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Cite This Page:

Mayo Clinic. "Mayo Clinic Studies Find Association Between Acid Reflux And Esophageal Cancer." ScienceDaily. ScienceDaily, 31 May 2006. <www.sciencedaily.com/releases/2006/05/060531095341.htm>.
Mayo Clinic. (2006, May 31). Mayo Clinic Studies Find Association Between Acid Reflux And Esophageal Cancer. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2006/05/060531095341.htm
Mayo Clinic. "Mayo Clinic Studies Find Association Between Acid Reflux And Esophageal Cancer." ScienceDaily. www.sciencedaily.com/releases/2006/05/060531095341.htm (accessed August 20, 2014).

Share This




More Health & Medicine News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com
101-Year-Old Working Man Has All The Advice You Need

101-Year-Old Working Man Has All The Advice You Need

Newsy (Aug. 19, 2014) Herman Goldman has worked at the same lighting store for almost 75 years. Find out his secrets to a happy, productive life. Video provided by Newsy
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com
American Ebola Patient Apparently Improving, Outbreak Is Not

American Ebola Patient Apparently Improving, Outbreak Is Not

Newsy (Aug. 19, 2014) Nancy Writebol, an American missionary who contracted Ebola, is apparently getting better, according to her husband. The outbreak, however, is not. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins