Featured Research

from universities, journals, and other organizations

New Research Promising For Improving Brain Cell Survival After Brain Injury

Date:
July 11, 2006
Source:
Howard Florey Institute
Summary:
Scientists at Melbourne's Howard Florey Institute have found a protein in the brain that can save neurons from dying after experiencing traumatic brain injury from incidents such as stroke, car accidents and falls.

Scientists at Melbourne's Howard Florey Institute have found a protein in the brain that can save neurons from dying after experiencing traumatic brain injury from incidents such as stroke, car accidents and falls.

The team, led by Professor Seong-Seng Tan, has discovered that this naturally occurring protein, called BP5, is produced more than usual in brain cells after they have experienced traumatic injury.

Prof Tan said that because this protein is “over-expressed”, it can prevent the neuron’s cells from dying, thus reducing brain damage.

“BP5’s pattern of expression indicates that it allows neurons to survive in a stressed environment,” Prof Tan said.

“We have tested this hypothesis in mice by expressing BP5 in stressed neurons and this proof-of-principle experiment showed that BP5 can prevent neurons from undergoing cell death.

“BP5 works by using the cell’s waste disposal system to flush away toxic and damaged proteins produced after injury, which appears to tip the balance towards nerve cell survival, instead of death,” he said.

Prof Tan is the first to show that this mechanism can be fruitfully manipulated to prevent brain cells from dying. For this reason, his work has been published by the Journal of Neuroscience, the peak body journal of the American Society for Neuroscience.

“Now our challenge is to understand how BP5 performs it neuron-saving function and develop drugs that can do the same thing,” Prof Tan said.

“Ultimately, we want to deliver the drug to patients suffering brain injury from stroke or trauma so save as many neurons as possible.

“Such a drug would limit damage to the brain after the injury, as well as the subsequent few days when injured nerves release ‘suicide factors’ that cause surrounding, healthy neurons to die en masse.

“This treatment to prevent brain damage has wide application and could be given to car accident and assault victims, people undergoing radiotherapy for brain tumours, premature babies that need to be induced, and stroke patients.

“While we still have a long way to go before such a drug will be available, this research is a promising step forward in the development of an effective treatment for traumatic brain injury,” Prof Tan said.

Prof Tan's discovery was assisted by funding from the Myer Family Foundation, the Victorian Trauma Foundation, and the Australian National Health and Medical Research Council. Finding an effective treatment for brain injury is urgent and this year, the Victorian State Government has committed $63 million to boost research into brain and spinal nerve injuries.

Prof Tan’s team at the Howard Florey Institute was assisted by researchers from the Alfred Trauma Research Centre, La Trobe University, Walter and Eliza Hall Research Institute of Medical Research and The Hanson Centre in Adelaide.

The Howard Florey Institute is Australia’s leading brain research centre. Its scientists undertake clinical and applied research that can be developed into treatments to combat brain disorders, and new medical practices. Their discoveries will improve the lives of those directly, and indirectly, affected by brain and mind disorders in Australia, and around the world. The Florey’s research areas cover a variety of brain and mind disorders including Parkinson’s disease, stroke, motor neuron disease, addiction, epilepsy, multiple sclerosis, autism and dementia.


Story Source:

The above story is based on materials provided by Howard Florey Institute. Note: Materials may be edited for content and length.


Cite This Page:

Howard Florey Institute. "New Research Promising For Improving Brain Cell Survival After Brain Injury." ScienceDaily. ScienceDaily, 11 July 2006. <www.sciencedaily.com/releases/2006/07/060711132311.htm>.
Howard Florey Institute. (2006, July 11). New Research Promising For Improving Brain Cell Survival After Brain Injury. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2006/07/060711132311.htm
Howard Florey Institute. "New Research Promising For Improving Brain Cell Survival After Brain Injury." ScienceDaily. www.sciencedaily.com/releases/2006/07/060711132311.htm (accessed September 2, 2014).

Share This




More Mind & Brain News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
Coffee Then Napping: The (New) Key To Alertness

Coffee Then Napping: The (New) Key To Alertness

Newsy (Aug. 30, 2014) Researchers say having a cup of coffee then taking a nap is more effective than a nap or coffee alone. Video provided by Newsy
Powered by NewsLook.com
Young Entrepreneurs Get $100,000, If They Quit School

Young Entrepreneurs Get $100,000, If They Quit School

AFP (Aug. 29, 2014) Twenty college-age students are getting 100,000 dollars from a Silicon Valley leader and a chance to live in San Francisco in order to work on the start-up project of their dreams, but they have to quit school first. Duration: 02:20 Video provided by AFP
Powered by NewsLook.com
Baby Babbling Might Lead To Faster Language Development

Baby Babbling Might Lead To Faster Language Development

Newsy (Aug. 29, 2014) A new study suggests babies develop language skills more quickly if their parents imitate the babies' sounds and expressions and talk to them often. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins