Featured Research

from universities, journals, and other organizations

Researchers Identify Very First Neurons In The 'Thinking' Brain

Date:
July 22, 2006
Source:
Yale University
Summary:
Researchers at Yale School of Medicine and the University of Oxford have identified the very first neurons in what develops into the cerebral cortex, the part of the brain that makes humans human. The findings published in Nature Neuroscience show that the first neurons, or "predecessors," as the researchers called them, are in place 31 days after fertilization. This is much earlier than previously thought and well before development of arms, legs or eyes.

The earliest identified neuron in the embryonic human cerebral cortex. Predecessor neuron is labeled golden, other proliferating cells are blue.
Credit: Image courtesy of Yale University

Researchers at Yale School of Medicine and the University of Oxford have identified the very first neurons in what develops into the cerebral cortex, the part of the brain that makes humans human.

The findings published in Nature Neuroscience show that the first neurons, or "predecessors," as the researchers called them, are in place 31 days after fertilization. This is much earlier than previously thought and well before development of arms, legs or eyes.

"These neurons, described here for the first time, precede all other known cell types of the developing cortex," the researchers said in their paper. "These precocious predecessor neurons might be important in the cascade of developmental events leading to the formation of the human cerebral cortex."

The cerebral cortex is largely responsible for human cognition, playing an essential role in perception, memory, thought, language, mental ability, intellect and consciousness. It is composed of about 20 billion neurons and accounts for 40 percent of the brain's weight.

Co-author Pasko Rakic, chair of the Department of Neurobiology and director of the Kavli Institute of Neuroscience at Yale, said the use of highly specific cell markers led the team to the surprising discovery of new types of neurons in the prospective cerebral cortex.

"We hypothesize that these predecessor neurons may be a transient population involved in determining the number of functional radial units including the human specific regions of the cerebral cortex mediating higher cognitive functions," Rakic said. "As a next step it is essential to determine their neural stem cell lineage, pattern of gene expression, developmental role and eventual fate."

Pinpointing the early development of the cerebral cortex may help in understanding the many developmental disorders of higher brain function, such as autism, schizophrenia, childhood epilepsy, developmental dyslexia and mental retardation. It also may explain how the human brain developed differently from that of other species.

Until recently it was thought that cortical neurons were generated locally, but this research team describes a distinctive, widespread population of neurons situated beneath the surface of the human embryonic forebrain even before complete closure of the neural tube.

Predecessor cells, unlike mature nerve cells, do not have synaptic connection with other neurons. They do have long processes, or "tails," with one stretching out in front of the cell body and the other trailing behind. Analysis of the skeleton of these cells suggests that they migrate upwards in the surface of the developing brain and enter the future cortex.

The researchers found that the processes form a vast network and they speculate that this web of processes might be used to control neuronal production, guide the migration of cells and determine the regional specification of the cerebral cortex.

Co-authors include Irina Bystron, Zoltan Molnar and Colin Blakemore of Oxford.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Researchers Identify Very First Neurons In The 'Thinking' Brain." ScienceDaily. ScienceDaily, 22 July 2006. <www.sciencedaily.com/releases/2006/07/060721182137.htm>.
Yale University. (2006, July 22). Researchers Identify Very First Neurons In The 'Thinking' Brain. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2006/07/060721182137.htm
Yale University. "Researchers Identify Very First Neurons In The 'Thinking' Brain." ScienceDaily. www.sciencedaily.com/releases/2006/07/060721182137.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins