Featured Research

from universities, journals, and other organizations

Researchers Create Mouse Lacking Key Inflammation Gene

Date:
September 12, 2006
Source:
Boston University
Summary:
Researchers from Boston University School of Dental Medicine have generated a mouse model exhibiting reduced inflammation. Researchers are offering this in vivo model for sale to spearhead discovery of drugs against inflammatory disorders such as arthritis and Crohn's disease.

In a paper published in The Proceedings of the National Academy of Science (PNAS), researchers from Boston University School of Dental Medicine generated a mouse model exhibiting reduced inflammation.

Related Articles


The Boston University researchers found that the transcription factor LITAF (Lipopolysaccharide [LPS]-Induced TNF-Alpha Factor) controls inflammation through a completely different pathway than the better known and studied NF-kB transcriptional regulator.

Drugs regulating TNF-alpha through the better-known NF-kB pathway such as Remicade, Embrel, and Humira represent a multibillion market. The LITAF transcription factor offers a new approach to treating inflammatory disorders along with other immunological conditions. Researchers are offering this in vivo model for sale to spearhead discovery of drugs against inflammatory disorders such as arthritis and Crohn's disease.

In the study, Boston University researchers created a mouse lacking the gene that encodes for the LITAF protein. They found that several cytokines were induced at lower levels in the LITAF-deficient mice compared with the levels observed in the LITAF-positive control mice. Specifically, the deficient mice were more resistant to LPS-induced lethality.

"The generation of the macrophage-specific LITAF-deficient animals opens new opportunities for assessing the role of LITAF in inflammation in hopes of designing anti-LITAF drugs for major inflammatory diseases," says Dr. Salomon Amar of Boston University, the lead author of the paper. Amar discovered the LITAF transcription factor in 1999.

Researchers, who have applied to patent the mouse, are now working on whether other molecules work in synergy with LITAF.


Story Source:

The above story is based on materials provided by Boston University. Note: Materials may be edited for content and length.


Cite This Page:

Boston University. "Researchers Create Mouse Lacking Key Inflammation Gene." ScienceDaily. ScienceDaily, 12 September 2006. <www.sciencedaily.com/releases/2006/09/060911112210.htm>.
Boston University. (2006, September 12). Researchers Create Mouse Lacking Key Inflammation Gene. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2006/09/060911112210.htm
Boston University. "Researchers Create Mouse Lacking Key Inflammation Gene." ScienceDaily. www.sciencedaily.com/releases/2006/09/060911112210.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Stray Dog Follows Adventure Racing Team for 6-Day Endurance Race

Stray Dog Follows Adventure Racing Team for 6-Day Endurance Race

Buzz60 (Nov. 24, 2014) A Swedish Adventure racing team travels to try and win a world title, but comes home with something way better: a stray dog that joined the team for much of the grueling 430-mile race. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com
Deadly Japanese Pufferfish Discovered in Crimean Waters

Deadly Japanese Pufferfish Discovered in Crimean Waters

Reuters - Light News Video Online (Nov. 24, 2014) The capture of deadly Japanese pufferfish in the waters of Crimea is causing concern for fishermen and scientists alike. Sharon Reich reports. Video provided by Reuters
Powered by NewsLook.com
Terrifying Black Seadevil Fish Captured on First-of-Its Kind Video

Terrifying Black Seadevil Fish Captured on First-of-Its Kind Video

Buzz60 (Nov. 24, 2014) An aquarium captures a first-of-its kind video of a notoriously camera-shy fish that’s also not so camera-friendly. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Red Panda Cubs Explore the Bratislava Zoo

Red Panda Cubs Explore the Bratislava Zoo

AFP (Nov. 24, 2014) Four-month old Red Panda twins Pim and Pam still rely on their mother for breast milk at the Bratislava Zoo in Slovakia, but the precocious cubs have begun to branch out to solid foods, as well. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins