Featured Research

from universities, journals, and other organizations

Calcineurin Helps Newborns Breathe Easy

Date:
September 23, 2006
Source:
Journal of Clinical Investigation
Summary:
Many premature babies suffer from the potentially life threatening respiratory distress syndrome because their lungs have not completed the final stages of development when they are born. A new study in the JCI shows that in mice a protein known as calcineurin is essential for complete lung development. This identification of one pathway controlling the final stages of lung development in mice might help researchers design strategies to treat respiratory distress syndrome in premature babies.

It is only very late in pregnancy that the lungs of the fetus complete their development so that the fetus will be able to breathe air when it is born. As a result, many premature babies suffer from the potentially life threatening respiratory distress syndrome. The proteins that control the final stages of lung development have not been identified.

Related Articles


Now, in a study appearing online on September 21, in advance of publication in the October print issue of the Journal of Clinical Investigation, Vrushank Dav้ and colleagues from the University of Cincinnati, show that in mice a protein known as calcineurin is essential for complete lung development.

Mice lacking calcineurin function in the epithelial cells of the lung were unable to breathe properly and died shortly after birth because their lungs failed to develop fully. These effects of calcineurin were mediated by a protein known as NFATc3, which was shown to activate the expression of many of the genes that need to be activated if the final stages of lung development are to proceed normally.

This study describes one pathway controlling the final stages of lung development in mice and might help researchers design strategies to treat respiratory distress syndrome in premature babies.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Calcineurin Helps Newborns Breathe Easy." ScienceDaily. ScienceDaily, 23 September 2006. <www.sciencedaily.com/releases/2006/09/060922093749.htm>.
Journal of Clinical Investigation. (2006, September 23). Calcineurin Helps Newborns Breathe Easy. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2006/09/060922093749.htm
Journal of Clinical Investigation. "Calcineurin Helps Newborns Breathe Easy." ScienceDaily. www.sciencedaily.com/releases/2006/09/060922093749.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) — As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
Dads-To-Be Also Experience Hormone Changes During Pregnancy

Dads-To-Be Also Experience Hormone Changes During Pregnancy

Newsy (Dec. 18, 2014) — A study from University of Michigan researchers found that expectant fathers see a decrease in testosterone as the baby's birth draws near. Video provided by Newsy
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) — Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) — Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins