Featured Research

from universities, journals, and other organizations

Fighting Cancer With Aspirin?

Date:
October 3, 2006
Source:
Federation of American Societies for Experimental Biology
Summary:
When looking for new weapons in the war on cancer, scientists should turn to their medicine cabinets for an age-old remedy -- aspirin. Scientists at the University of Newcastle have determined that aspirin has cancer-fighting effects extending beyond Cox inhibitors. This finding, appearing in the October 2006 issue of the FASEB Journal, allows researchers to pursue new lines of investigation that could ultimately yield a new type of cancer-fighting drug.

When looking for new weapons in the war on cancer, scientists should turn to their medicine cabinets for an age-old remedy--aspirin. According to scientists at the University of Newcastle (UK), aspirin has cancer-fighting effects that extend beyond already understood Cox inhibitors.

This finding, which appears in the October 2006 issue of The FASEB Journal, provides important clues to how aspirin works in cancer and in inflammation: aspirin reduces the formation of blood vessels that fuel developing tumors. Without new blood vessels (formed through a process called angiogenesis) tumors cannot grow. With this information, researchers can pursue new lines of investigation that could ultimately yield an entirely new type of cancer-fighting drug.

In the study, the researchers show that aspirin acts on the signaling molecule NFkappaB, which is known to trigger the formation of new blood vessels, an important part of tumor development. Additionally, Newcastle researchers found a dose-dependent relationship between blood vessel formation and the amount of aspirin used in the study. This new finding confirms and extends earlier evidence suggesting that NFkappaB is a target of aspirin action in inflammation; now researchers can work out exactly how signals interrupted by aspirin can control not only inflammation, but the biology of tumor growth as well.

"Aspirin has always been touted as a 'wonder drug,'" said Gerald Weissmann, MD, Editor-in-Chief of The FASEB Journal, "and this study shows that we are still learning about the many actions of this amazing drug."

The FASEB Journal (http://www.fasebj.org) is published by the Federation of American Societies for Experimental Biology (FASEB) and is consistently ranked among the top three biology journals worldwide by the Institute for Scientific Information. FASEB comprises 21 nonprofit societies with more than 80,000 members, making it the largest coalition of biomedical research associations in the United States. FASEB's mission is to enhance the ability of biomedical and life scientists to improve -- through their research -- the health, well-being and productivity of all people. FASEB serves the interests of these scientists in those areas related to public policy, facilitates coalition activities among member societies and disseminates information on biological research through scientific conferences and publications.


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Cite This Page:

Federation of American Societies for Experimental Biology. "Fighting Cancer With Aspirin?." ScienceDaily. ScienceDaily, 3 October 2006. <www.sciencedaily.com/releases/2006/10/061002215512.htm>.
Federation of American Societies for Experimental Biology. (2006, October 3). Fighting Cancer With Aspirin?. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2006/10/061002215512.htm
Federation of American Societies for Experimental Biology. "Fighting Cancer With Aspirin?." ScienceDaily. www.sciencedaily.com/releases/2006/10/061002215512.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins