Featured Research

from universities, journals, and other organizations

New Gene Linked To Bipolar Disorder

Date:
October 3, 2006
Source:
University College London
Summary:
A new gene linked to both depression and bipolar disorder has been identified by University College London and Danish researchers.

A new gene linked to both depression and bipolar disorder has been identified by UCL (University College London) and Danish researchers.

The collaboration, led by Professor Hugh Gurling at UCL and Professor Ole Mors at the University of Aarhus, first looked at bipolar cases in families living in the UK and in Denmark, and then at large numbers of unrelated people with bipolar disorder. The results of the genetic searches, published in the October issue of the American Journal of Psychiatry, identified the gene -- known as Slynar -- which is found on chromosome 12.

Bipolar disorder is known to run strongly in families, but the Slynar gene is one of just three genes now known to be implicated in susceptibility to the disorder. This gene appears to be present in around 10 per cent of bipolar disorder cases. Previous studies of families have already shown that there are multiple genetic subtypes of the disorder, but progress in identifying the exact genes responsible has been slow because groups of families inherit different susceptibility genes.

The Slynar gene is normally found in the brain, but in bipolar disorder has an abnormal effect due to mutations in the gene. However, researchers do not yet know what the gene's normal function is or how these mutations might be contributing to the disorder.

Professor Hugh Gurling, UCL Department of Mental Health Sciences, says: "The next step is to determine the role of the Slynar gene in the brain and how abnormalities in this gene may cause bipolar disorder. Using techniques such as animal models will help us to fully understand the mechanisms behind this gene and explore how we might be able to intervene in these mechanisms, to help people with the disorder.

"We hope our discovery will eventually lead to new treatments for depression and bipolar disorder, including possible preventive strategies, for example with drugs or even through nutritional intervention."

Around one in every 200 people in the UK develops bipolar and other related mood disorders. Signs of depression include losing weight, feeling totally negative about oneself, feel hopeless about the future and sometimes ending up in a depressive stupor in bed, unable to move, eat, drink or talk. People with bipolar disorder may also experience extreme mood highs, overactivity, increased libido, sleeplessness and grandiose delusions.


Story Source:

The above story is based on materials provided by University College London. Note: Materials may be edited for content and length.


Cite This Page:

University College London. "New Gene Linked To Bipolar Disorder." ScienceDaily. ScienceDaily, 3 October 2006. <www.sciencedaily.com/releases/2006/10/061003085831.htm>.
University College London. (2006, October 3). New Gene Linked To Bipolar Disorder. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2006/10/061003085831.htm
University College London. "New Gene Linked To Bipolar Disorder." ScienceDaily. www.sciencedaily.com/releases/2006/10/061003085831.htm (accessed September 23, 2014).

Share This



More Mind & Brain News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Food Addiction Might Be Caused By PTSD

Food Addiction Might Be Caused By PTSD

Newsy (Sep. 18, 2014) New research shows that women who suffer from PTSD are three times more likely to develop a food addiction. Video provided by Newsy
Powered by NewsLook.com
Corporal Punishment on Decline, Debate Renews

Corporal Punishment on Decline, Debate Renews

AP (Sep. 16, 2014) Corporal punishment in the United States is on the decline, but there is renewed debate over its use after Minnesota Vikings running back Adrian Peterson was charged with child abuse. (Sept. 16) Video provided by AP
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins