Featured Research

from universities, journals, and other organizations

Mayo Clinic Researchers Recommend Embryo Transfer Delay For At-risk Women

Date:
October 26, 2006
Source:
Mayo Clinic
Summary:
Mayo Clinic researchers have determined a method to achieve the best results for the mother's health and birth of a live baby for women who undergo in vitro fertilization who demonstrate risk of ovarian hyperstimulation syndrome.

Mayo Clinic researchers have determined a method to achieve the best results for the mother's health and birth of a live baby for women who undergo in vitro fertilization who demonstrate risk of ovarian hyperstimulation syndrome. Embryo transfer into the mother's uterus is delayed after the fertilization of the mother's eggs in the laboratory, and all embryos are frozen until the mother's risk subsides naturally with time. Findings will be presented as an abstract at the American Society for Reproductive Medicine in New Orleans on Tuesday, Oct. 24.

Related Articles


"We take steps to minimize ovarian hyperstimulation syndrome as an issue," says Charles Coddington, M.D., Mayo Clinic reproductive endocrinologist and senior study researcher. "If we feel that there's a good chance a woman would get this syndrome, then we would recommend complete cryopreservation -- freezing -- of her embryos and waiting about a month or so to complete the embryo transfer."

Ovarian hyperstimulation syndrome occurs in approximately 5 percent of women treated with medications to prompt ovulation, the first step in the in vitro fertilization process. A small percentage of those who develop the syndrome (1 to 2 percent) may experience a life-threatening illness. After stimulation, a woman's ovaries can become highly sensitive to hormonal change and start to enlarge, sometimes to orange or grapefruit size, rather than the normal walnut size. Enlargement of ovaries can be painful, as they are surrounded by a tunic that does not allow stretching. The stretched ovaries also secrete fluid into the abdomen, giving the woman a feeling of fullness, which may cause difficulty breathing. Because the fluid has left the vascular system, in a small number of cases, the woman may develop problems with the kidneys or with thrombosis. In extreme cases, blood clots can form in the legs, which can lead to pulmonary embolism.

In this study, the investigators retrospectively analyzed the medical records of 1,002 Mayo Clinic patients who had undergone in vitro fertilization between 2000 and 2004. They found 188 patients at risk for ovarian hyperstimulation syndrome, represented by high estradiol (estrogenic hormone) levels and the development of a large number of follicles in the ovaries. Three different treatment strategies were employed with the women at risk: the cycles of 21 were coasted (medication to stimulate the ovaries that is normally given daily was withheld for a day); all embryos of 32 patients were frozen, delaying transfer to the mother's uterus until the symptoms of risk subsided; and in the remaining 135 patients, with no other risk factors for ovarian hyperstimulation, physicians did not delay embryo transfer to the mother's uterus. Balancing the resulting live births with the health issues and hospitalization costs in the women who developed ovarian hyperstimulation syndrome using these three methods, the investigators found that the freezing and delaying procedure produced the best overall results.

"We conclude that elective embryo cryopreservation with subsequent embryo transfer is an effective way of preventing severe ovarian hyperstimulation syndrome and its life-threatening consequences," says Dr. Coddington. "The quality and pregnancy potential of the frozen embryos remains excellent, as demonstrated by the high cumulative live birth rate per patient."

Though women can develop an early form of this syndrome before pregnancy is achieved through in vitro fertilization like the women in this study, other women experience ovarian hyperstimulation syndrome after embryo transfer and subsequent pregnancy, and the pregnancy hormone exacerbates hyperstimulation. If the mother is pregnant, the syndrome does not pose a risk to the baby, as long as the mother remains stable, says Dr. Coddington.

What causes the syndrome and why it affects those it does are unknown, according to Dr. Coddington.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Cite This Page:

Mayo Clinic. "Mayo Clinic Researchers Recommend Embryo Transfer Delay For At-risk Women." ScienceDaily. ScienceDaily, 26 October 2006. <www.sciencedaily.com/releases/2006/10/061025085444.htm>.
Mayo Clinic. (2006, October 26). Mayo Clinic Researchers Recommend Embryo Transfer Delay For At-risk Women. ScienceDaily. Retrieved November 21, 2014 from www.sciencedaily.com/releases/2006/10/061025085444.htm
Mayo Clinic. "Mayo Clinic Researchers Recommend Embryo Transfer Delay For At-risk Women." ScienceDaily. www.sciencedaily.com/releases/2006/10/061025085444.htm (accessed November 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN Says It Will Scale Up Its Ebola Response

UN Says It Will Scale Up Its Ebola Response

AFP (Nov. 20, 2014) UN Resident Coordinator David McLachlan-Karr and WHO representative in the country Daniel Kertesz updated the media on the UN Ebola response on Wednesday. Duration: 00:51 Video provided by AFP
Powered by NewsLook.com
Takata Offers "sincerest Condolences" To Victims of Malfunctioning Airbag

Takata Offers "sincerest Condolences" To Victims of Malfunctioning Airbag

Reuters - US Online Video (Nov. 20, 2014) U.S. Congress hears from a victim and company officials as it holds a hearing on the safety of Takata airbags after reports of injuries. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Obesity Costs Almost As Much As War And Terrorism

Obesity Costs Almost As Much As War And Terrorism

Newsy (Nov. 20, 2014) The newest estimate of the cost of obesity is pretty jarring — $2 trillion. But how did researchers get to that number? Video provided by Newsy
Powered by NewsLook.com
Calling All Men: Here's Your Chance to Experience Labor Pains

Calling All Men: Here's Your Chance to Experience Labor Pains

Reuters - Light News Video Online (Nov. 20, 2014) Chinese hospital offers men a chance to experience the pain of child birth via electric shocks. Sharon Reich reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins