Featured Research

from universities, journals, and other organizations

Bacteria Could Make New Library Of Cancer Drugs That Are Too Complex To Create Artificially

Date:
November 1, 2006
Source:
University of Warwick
Summary:
Researchers at the University of Warwick are examining a way of using bacteria to manufacture a new suite of potential anti-cancer drugs that are difficult to create synthetically on a lab bench. The bacterium Streptomyces coelicolor naturally produce antibiotics called prodiginines.

A colony of S. coelicolor bacteria that could be used to make a prodiginine such as streptorubin (shown in yellow).
Credit: Image courtesy of University of Warwick

Researchers at the University of Warwick are examining a way of using bacteria to manufacture a new suite of potential anti-cancer drugs that are difficult to create synthetically on a lab bench.

The bacterium Streptomyces coelicolor naturally produce antibiotics called prodiginines.

This group of antibiotics has stimulated much recent interest as they can be used to target and kill cancer cells. A synthetic prodiginine analogue called GX15-070 is currently in phase 1 and 2 cancer treatment trials. However, analogues of other prodiginines, such as streptorubin B, could be even more powerful anti cancer tools, but they cannot currently be easily synthetically produced on a lab bench.

Professor Greg Challis and colleagues in the Chemistry Department of the University of Warwick have looked at the enzymes controlling the process that allows the bacterium Streptomyces coelicolor to create streptorubin B and have gained a clear understanding of which are the key enzymes that act at particular steps of that process. By manipulation of the enzyme content of the bacteria, they aim to produce a range of different compounds based closely on the form of streptorubin B normally formed by the bacteria. Some of these analogues of streptorubin B could provide the basis for developing useful new anti cancer drugs.

Professor Challis said: "This approach combines the strengths of conventional organic synthesis, with the synthetic power of biology, to assemble complex and synthetically difficult structures. It could be particularly valuable for generating analogues of streptorubin B with all the promise that holds for the development of new anti cancer drugs"


Story Source:

The above story is based on materials provided by University of Warwick. Note: Materials may be edited for content and length.


Cite This Page:

University of Warwick. "Bacteria Could Make New Library Of Cancer Drugs That Are Too Complex To Create Artificially." ScienceDaily. ScienceDaily, 1 November 2006. <www.sciencedaily.com/releases/2006/10/061031185318.htm>.
University of Warwick. (2006, November 1). Bacteria Could Make New Library Of Cancer Drugs That Are Too Complex To Create Artificially. ScienceDaily. Retrieved September 19, 2014 from www.sciencedaily.com/releases/2006/10/061031185318.htm
University of Warwick. "Bacteria Could Make New Library Of Cancer Drugs That Are Too Complex To Create Artificially." ScienceDaily. www.sciencedaily.com/releases/2006/10/061031185318.htm (accessed September 19, 2014).

Share This



More Health & Medicine News

Friday, September 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com
What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
U.S. Food Makers Surpass Calorie-Cutting Pledge

U.S. Food Makers Surpass Calorie-Cutting Pledge

Newsy (Sep. 18, 2014) Sixteen large food and beverage companies in the United States that committed to cut calories in their products far surpassed their target. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins