Featured Research

from universities, journals, and other organizations

Researchers Turn Cord Blood Into Lung Cells

Date:
November 13, 2006
Source:
University of Minnesota
Summary:
Researchers at the University of Minnesota have, for the first time, coaxed umbilical cord blood stem cells to differentiate into a type of lung cell.

Researchers at the University of Minnesota have, for the first time, coaxed umbilical cord blood stem cells to differentiate into a type of lung cell.

The cord blood cells differentiated into a type of lung cell called type II alveolar cells. These cells are responsible for secreting surfactant, a substance which allows the air sacs in the lungs to remain open, allowing air to move in and out of the sacs. The cells are also responsible for helping to repair the airway after injury.

"In the future, we may be able to examine cord blood from babies who have lung diseases, such as cystic fibrosis, to do more research to understand how these diseases evolve as well as to develop better medical treatments," said David McKenna, M.D., assistant professor of lab medicine and pathology and medical director of the Clinical Cell Therapy Lab at the University of Minnesota Medical Center, Fairview.

The research paper is currently available online, and will be published in the Nov. 7, 2006, issue of the journal Cytotherapy.

Type II alveolar cells develop late in fetal development, which is why some premature babies are born with underdeveloped lungs. The cells and the air sacs as a whole continue to mature and develop through a child's first few years of life.

Now the researchers will try to better characterize the cells, so that in the future, the cells could be used as a research tool to better understand lung development and disease. The cells may also be useful as a way to test potential new drugs.

To differentiate the lung cells from the cord blood, McKenna and his team first derived the Multi-Lineage Progenitor CellTM (MLPCTM) from umbilical cord blood. This stem cell, which was first isolated and characterized by BioEฎ, Inc., St. Paul, is a precursor cell that can be expanded in culture, then differentiated into different types of tissue representative of all three embryonic lineages, endoderm, mesoderm and ectoderm.

In this series of experiments, McKenna and his group cultured the MLPC and differentiated it into the lung cells, an endoderm-type cell. By testing the cells that grew with various methods, they were able to find cells that exhibited key markers present in type II alveolar cells.

The research was funded by BioE, Inc.


Story Source:

The above story is based on materials provided by University of Minnesota. Note: Materials may be edited for content and length.


Cite This Page:

University of Minnesota. "Researchers Turn Cord Blood Into Lung Cells." ScienceDaily. ScienceDaily, 13 November 2006. <www.sciencedaily.com/releases/2006/11/061101150949.htm>.
University of Minnesota. (2006, November 13). Researchers Turn Cord Blood Into Lung Cells. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2006/11/061101150949.htm
University of Minnesota. "Researchers Turn Cord Blood Into Lung Cells." ScienceDaily. www.sciencedaily.com/releases/2006/11/061101150949.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) — The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) — Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) — Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins