Featured Research

from universities, journals, and other organizations

Viagra For Babies? Sildenafil Found To Prevent Rebound Pulmonary Hypertension In Infants

Date:
November 2, 2006
Source:
American Thoracic Society
Summary:
A single dose of sildenafil, a blood vessel widening vasodilator (also sold under the brand name Viagra), prevented rebound pulmonary hypertension and significantly reduced the duration of mechanical ventilation in intensive care unit (ICU) infants being withdrawn from inhaled nitric oxide therapy. This research appears in the first issue for November 2006 of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

A single dose of sildenafil, a blood vessel widening vasodilator (also sold under the brand name Viagra), prevented rebound pulmonary hypertension and significantly reduced the duration of mechanical ventilation in intensive care unit (ICU) infants being withdrawn from inhaled nitric oxide therapy.

This research appears in the first issue for November 2006 of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

Lara Shekerdemian, M.D., of the Pediatric Intensive Care Unit at the Royal Children's Hospital in Melbourne, Australia, and five associates gave a single dose of sildenafil to 15 infants undergoing withdrawal from inhaled nitric oxide therapy. None experienced rebound pulmonary hypertension, a common therapeutic complication.

Fourteen children in the study cohort received a placebo. Ten of the 14 had an acute elevation of pulmonary artery pressure by 20 percent or more during the latter part of the weaning process.

Inhaled nitric oxide was first introduced in the early 1990s as a therapeutic agent to widen pulmonary blood vessels in ventilated lung regions by relaxing pulmonary vascular smooth muscle.

Although there have been no definitive studies of clinical benefit to date, the investigators believe that inhaled nitric oxide therapy warrants use as an adjunctive treatment in some of the sickest patients in the ICU. They call it "unrivaled" in its efficacy as a selective pulmonary vasodilator.

"An important complication that is associated with the use of inhaled nitric oxide is the development of rebound pulmonary hypertension on its withdrawal," said Dr. Shekerdemian.

All infants who failed to respond were given sildenafil during a subsequent weaning attempt more than 24 hours later and were weaned successfully from nitric oxide treatment.

The total duration of ventilation for patients given sildenafil was slightly over 28 hours, as compared with 98 hours for those taking a placebo.

"The total ICU stay after the study was completed was 47.8 hours for the sildenafil group and 189 hours for the placebo group," added Dr. Shekerdemian.

"This study is unique in a number of ways," she continued. "It is the first study to investigate the pharmacologic prophylaxis of rebound pulmonary hypertension during the primary attempt to wean from inhaled nitric oxide. This is also the first prospective trial of sildenafil in the prevention of rebound pulmonary hypertension. Moreover, this study is the first that defines the extent of the problem of rebound pulmonary hypertension in infants and children weaning from inhaled nitric oxide in the pediatric ICU."


Story Source:

The above story is based on materials provided by American Thoracic Society. Note: Materials may be edited for content and length.


Cite This Page:

American Thoracic Society. "Viagra For Babies? Sildenafil Found To Prevent Rebound Pulmonary Hypertension In Infants." ScienceDaily. ScienceDaily, 2 November 2006. <www.sciencedaily.com/releases/2006/11/061101151450.htm>.
American Thoracic Society. (2006, November 2). Viagra For Babies? Sildenafil Found To Prevent Rebound Pulmonary Hypertension In Infants. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2006/11/061101151450.htm
American Thoracic Society. "Viagra For Babies? Sildenafil Found To Prevent Rebound Pulmonary Hypertension In Infants." ScienceDaily. www.sciencedaily.com/releases/2006/11/061101151450.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins