Featured Research

from universities, journals, and other organizations

Stem Cells Get A Grip

Date:
December 15, 2006
Source:
American Society for Cell Biology
Summary:
At the American Society for Cell Biology's 2006 conference, scientists will describe how live cell imaging has revealed the very close relationship of hematopoietic stem cells and osteoblasts in the stem cell niche.

In real estate, it's location, location, location. In stem cells, it's niche, niche, niche.

Related Articles


Stems cells are regulated by "intrinsic factors" but it's also becoming increasingly clear that their "stemness" depends on the unique microenvironment called the stem cell niche.

No adult or somatic stem cells have a more complex niche life than hematopoietic stem cells, which give rise to all the different types of blood and immune cells. The bone marrow is their niche. It's a crowded neighborhood, teeming with different cell types such as fibroblasts, adipocytes, macrophages, and endothelial cells. Hematopoietic stem cells also share their bone marrow niche with osteoblasts, the body's bone-forming cells, which are derived from a different stem cell population called bone marrow stromal cells. The two stem cells lines probably have a common progenitor but for now scientists can only regard hematopoietic stem cells and osteoblasts as niche neighbors. But it's a very close relationship, as researchers in the National Institute of Child Health & Human Development laboratory of Jennifer Lippincott-Schwartz now reveal in great detail.

Earlier reports had established that osteoblasts are a crucial component of the hematopoietic stem cell niche and that physical contact with osteoblasts was vital for their survival. The Lippincott-Schwartz lab used live cell imaging techniques to see what happens when the two cell types are put together, directing their attention in particular at the point of cell-cell contact, and how it affects the cellular and molecular relationship of the two cell types.

The NIH researchers observed dynamic amoeboid motility toward the osteoblasts by both human CD34+ hematopoietic progenitor cells and KG1 cells, which are a hematopoietic subset of myeloid progenitors. The progenitor cells assumed a polarized morphology with a leading edge structure and a foot-like "special domain" projection from the cell's trailing edge called a uropod. It was through this foot that the hematopoietic stem cells took hold of the osteoblasts. The uropod contact point was enriched in the cholera toxin B subunit, a lipid raft molecule, as well as the stem cell marker CD133.

The researchers had seeded the outside of the progenitor cells with microscopic markers, quantum dot nanocrystals, and watched as the dots were taken into the cells and delivered specifically to the uropod domain at the point of contact. Interestingly, time-lapse microscopy detected transfer of the quantum dots from the progenitor cells to the osteoblastic cells, suggesting an intercellular transfer of cell-associated molecules. Immune cells are known to transfer cell-surface molecules during cell-cell interactions so a similar intercellular transfer between hematopoietic progenitors and osteoblasts could be of broad biological significance, the researchers say. Further studies will explore how these close neighbors pull together in the hematopoietic niche.


Story Source:

The above story is based on materials provided by American Society for Cell Biology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Cell Biology. "Stem Cells Get A Grip." ScienceDaily. ScienceDaily, 15 December 2006. <www.sciencedaily.com/releases/2006/12/061215091126.htm>.
American Society for Cell Biology. (2006, December 15). Stem Cells Get A Grip. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2006/12/061215091126.htm
American Society for Cell Biology. "Stem Cells Get A Grip." ScienceDaily. www.sciencedaily.com/releases/2006/12/061215091126.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins