Featured Research

from universities, journals, and other organizations

How Many Genes Does It Take To Learn? Lessons From Sea Slugs

Date:
December 29, 2006
Source:
University of Florida
Summary:
At any given time within just a single brain cell of sea slug known as Aplysia, more than 10,000 genes are active, according to scientists writing in Cell. Researchers also analyzed 146 human genes implicated in 168 neurological disorders, including Parkinson's and Alzheimer's diseases, and genes controlling aging and stem-cell differentiation. They found 104 counterpart genes in Aplysia, suggesting it will be a valuable tool for developing treatments for neurodegenerative diseases.

Leonid Moroz, a professor of neuroscience and zoology at the University of Florida Whitney Laboratory for Marine Bioscience, has found that gene sequences in a simple marine snail called.
Credit: Sarah Kiewel/UF HSC News

Scientists analyzing the genomics of a marine snail have gotten an unprecedented look at brain mechanisms, discovering that the neural processes in even a simple sea creature are far from sluggish.

At any given time within just a single brain cell of sea slug known as Aplysia, more than 10,000 genes are active, according to scientists writing in Friday's (Dec. 29, 2006) edition of the journal Cell. The findings suggest that acts of learning or the progression of brain disorders do not take place in isolation - large clusters of genes within an untold amount of cells contribute to major neural events.

"For the first time we provide a genomic dissection of the memory-forming network," said Leonid Moroz, a professor of neuroscience and zoology at the University of Florida Whitney Laboratory for Marine Bioscience. "We took advantage of this powerful model of neurobiology and identified thousands of genes operating within a single neuron. Just during any simple event related to memory formation, we expect differences in gene expression for at least 200 to 400 genes."

Researchers studied gene expression in association with specific networks controlling feeding or defensive reflexes in the sea slug. To their surprise, they identified more than 100 genes similar to those associated with all major human neurological diseases and more than 600 genes controlling development, confirming that molecular and genomic events underlying key neuronal functions were developed in early animal ancestors and remained practically unchanged for more than 530 million years of independent evolution in the lineages leading to men or sea slugs.

Moroz and his collaborators uncovered new information that suggest that gene loss in the evolution of the nervous system is as important as gene gain in terms of adaptive strategies. They believe that a common ancestor of animals had a complex genome and different genes controlling brain or immune functions were lost independently in different lineages of animals, including humans.

Until now, scientists have been largely in the dark about how genes control the generation of specific brain circuitry and how genes modify that circuitry to enable learning and memory. For that matter, little is known about the genes that distinguish one neuron from the next, even though they may function quite differently.

Molecular analyses of Aplysia neuronal genes are shedding light on these elusive processes. In 2000, senior author Eric Kandel, M.D., of Columbia University in New York shared the Nobel Prize in Physiology or Medicine for his work using Aplysia as a model of how memories are formed in the human brain.

Despite its simple nervous system - Aplysia has about 10,000 large neurons that can be easily identified, compared with about one hundred billion neurons in humans - the animal is capable of learning and its brain cells communicate in many ways identical to human neural communication.

In the new findings, scientists identified more than 175,000 gene tags useful for understanding brain functions, increasing by more than 100 times the amount of genomic information available for study, according to Moroz and 22 other researchers from UF and Columbia University. More than half of the genes have clear counterparts in humans and can be linked to a defined neuronal circuitry, including a simple memory-forming network.

"In the human brain there are a hundred billion neurons, each expressing at least 18,000 genes, and the level of expression of each gene is different," said Moroz, who is affiliated with UF's Evelyn F. and William L. McKnight Brain Institute and the UF Genetics Institute. "Understanding individual genes or proteins is important, but this is a sort of molecular alphabet. This helps us learn the molecular grammar, or a set of rules that can control orchestrated activity of multiple genes in specific neurons. If we are going to understand memory or neurological disease at the cellular level, we need to understand the rules."

Scientists also analyzed 146 human genes implicated in 168 neurological disorders, including Parkinson's and Alzheimer's diseases, and genes controlling aging and stem-cell differentiation. They found 104 counterpart genes in Aplysia, suggesting it will be a valuable tool for developing treatments for neurodegenerative diseases.

"The authors have assembled a tremendous amount of data on gene transcripts associated with neuronal signaling pathways in Aplysia that sheds new light on evolutionary relationships of this very ancient and highly successful marine animal," said Dennis Steindler, Ph.D., executive director of UF's McKnight Brain Institute, who did not participate in the research. "A very important part of this study is the discovery of novel genes not formerly associated with the mollusk genome that include many associated with neurological disorders."

The findings are especially important for scientists using mollusks in experimental systems, according to Edgar Walters, Ph.D., a professor of integrative biology and pharmacology at the University of Texas Medical School at Houston, who was not involved in the research.

"Few animals other than Aplysia allow scientists to relate a molecular pathway directly to the function of a cell, all in context with an animal's behavior," Walters said. "In a mammal, it's hard to identify and manipulate a single cell and know what its function is. With Aplysia, there is direct access to whatever cell you're interested in with just a micropipette. As a scientist who wants to know which molecules are present in Aplysia for experimental manipulation, I am very happy to see this paper come out."


Story Source:

The above story is based on materials provided by University of Florida. Note: Materials may be edited for content and length.


Cite This Page:

University of Florida. "How Many Genes Does It Take To Learn? Lessons From Sea Slugs." ScienceDaily. ScienceDaily, 29 December 2006. <www.sciencedaily.com/releases/2006/12/061228131329.htm>.
University of Florida. (2006, December 29). How Many Genes Does It Take To Learn? Lessons From Sea Slugs. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2006/12/061228131329.htm
University of Florida. "How Many Genes Does It Take To Learn? Lessons From Sea Slugs." ScienceDaily. www.sciencedaily.com/releases/2006/12/061228131329.htm (accessed September 2, 2014).

Share This




More Plants & Animals News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Washington Wildlife Center Goes Nuts Over Baby Squirrels

Washington Wildlife Center Goes Nuts Over Baby Squirrels

Reuters - US Online Video (Aug. 30, 2014) An animal rescue in Washington state receives an influx of orphaned squirrels, keeping workers busy as they nurse them back to health. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Experimental Ebola Drug ZMapp Cures Lab Monkeys Of Disease

Experimental Ebola Drug ZMapp Cures Lab Monkeys Of Disease

Newsy (Aug. 29, 2014) In a new study, a promising experimental treatment for Ebola managed to cure a group of infected macaque monkeys. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins