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What Makes Epithelial Cells Change Their Identity?

Date:
February 6, 2007
Source:
Journal of Clinical Investigation
Summary:
During development and during pathological processes in the adult, cells are constantly changing their function. One, well-characterized, cellular transition that occurs during development, as well as during wound healing, tissue fibrosis, and tumor metastasis, is the transition from an epithelial cell to a mesenchymal cell (often a fibroblast).
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During development and during pathological processes in the adult, cells are constantly changing their function. One, well-characterized, cellular transition that occurs during development, as well as during wound healing, tissue fibrosis, and tumor metastasis, is the transition from an epithelial cell to a mesenchymal cell (often a fibroblast).

This change in cell type and function is known as epithelial-mesenchymal transition (EMT) and it has been shown that a protein known as FSP1 is important for this transition. However, the proteins that direct the change in the pattern of genes expressed, so that epithelial cells can undergo EMT, have not been completely defined.

In a study appearing in the February issue of the Journal of Clinical Investigation, Eric Neilson and colleagues from Vanderbilt University, Nashville, identify two proteins, CBF-A and KAP-1, as crucial for initiating EMT. CBF-A and KAP-1 were shown, by two independent mechanisms, to bind a regulatory region of DNA in the gene encoding FSP1. This regulatory region of DNA is known as FTS-1 and the binding of proteins to FTS-1 has previously been shown to drive the expression of FSP1. Further analysis by Neilson and colleagues showed that in kidney epithelial cells engineered to express CBF-A a complex composed of CBF-A, KAP-1, and FST-1 formed and that this triggered EMT.

This study indicated that the CBF-A/KAP-1/FTS-1 complex is an early regulator of EMT and the authors suggest that it might be the master regulatory complex in this important process.

In an accompanying commentary, Raghu Kalluri and colleagues from Harvard Medical School, Boston, clarify the importance of this study for our understanding of EMT and suggest that the CBF-A/KAP-1/FTS-1 complex might be a good therapeutic target for the treatment of diseases in which EMT features prominently, such as tissue fibrosis.


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The above post is reprinted from materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


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Journal of Clinical Investigation. "What Makes Epithelial Cells Change Their Identity?." ScienceDaily. ScienceDaily, 6 February 2007. <www.sciencedaily.com/releases/2007/02/070204112245.htm>.
Journal of Clinical Investigation. (2007, February 6). What Makes Epithelial Cells Change Their Identity?. ScienceDaily. Retrieved July 29, 2015 from www.sciencedaily.com/releases/2007/02/070204112245.htm
Journal of Clinical Investigation. "What Makes Epithelial Cells Change Their Identity?." ScienceDaily. www.sciencedaily.com/releases/2007/02/070204112245.htm (accessed July 29, 2015).

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