Featured Research

from universities, journals, and other organizations

Researchers Identify Factor In Pathogenesis Of Graves' Disease

Date:
February 19, 2007
Source:
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)
Summary:
Investigators at the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed) have found evidence that continues to implicate insulin-like growth factor receptor (IGF-1R) in the development of Graves' disease.

Investigators at the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed) have found evidence that continues to implicate insulin-like growth factor receptor (IGF-1R) in the development of Graves' disease.

In previous research published in the Journal of Immunology, Terry J. Smith, M.D. and Raymond Douglas, M.D., Ph.D. have identified the interaction between immunoglobulins and IGF-1R as a cause of inflammation and lymphocyte infiltration in both Graves' disease and rheumatoid arthritis. The discovery of these mechanisms in a similar class of autoimmune diseases supports the belief that a single biological mechanism is activating a variety of autoimmune diseases. The identification of such a mechanism may lead to a common therapeutic strategy for these conditions.

According to Dr. Smith, "We continue to build a body of evidence that suggests that a single biological mechanism can activate a variety of autoimmune diseases. It is possible that these findings will allow us for the first time to interrupt the disease process before any lasting damage is done. It could be involved in other autoimmune disorders as well; we're thinking about a large number of diseases."

In the article appearing in the March 1, 2007 issue of the Journal of Immunology, Dr. Smith and his colleagues report that a disproportionately large fraction of peripheral blood T cells express IGF-1R in patients with Graves' disease. The results support a potential role for IGF-1R as a determinant of immune responses through fibroblast and lymphocyte activation and expansion. This further implicates IGF-1R in the pathogenesis of patients with Graves' disease.

Graves' disease, the most common cause of hyperthyroidism, can lead to severe swelling around the eye sockets. It is part of a class of autoimmune disorders in which cellular defense mechanisms mistakenly identify the body's own tissues as foreign and seek to destroy them. Other autoimmune disorders in the same class include rheumatoid arthritis, multiple sclerosis, and lupus. 37,000 new patients per year are diagnosed with Graves' disease in the United States.

"Autoimmune diseases are among the most insidious and debilitating of human ailments," said LA BioMed President and CEO Kenneth P. Trevett, J.D. "We are working closely with Dr. Smith and his colleagues to facilitate this work and promote its transfer to the patient bedside."

The Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed) is one of the largest independent, not-for-profit biomedical research institutes in Los Angeles County. Affiliated with both the David Geffen School of Medicine at UCLA and the Harbor-UCLA Medical Center, the Institute has an annual budget of over $75 million and currently supports more than 1,000 research studies in areas such as cardiology, emerging infections, cancer, women's health, reproductive health, vaccine research, respiratory physiology, dermatology, neonatology, molecular biology, and genetics.


Story Source:

The above story is based on materials provided by Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed). Note: Materials may be edited for content and length.


Cite This Page:

Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed). "Researchers Identify Factor In Pathogenesis Of Graves' Disease." ScienceDaily. ScienceDaily, 19 February 2007. <www.sciencedaily.com/releases/2007/02/070218135419.htm>.
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed). (2007, February 19). Researchers Identify Factor In Pathogenesis Of Graves' Disease. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2007/02/070218135419.htm
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed). "Researchers Identify Factor In Pathogenesis Of Graves' Disease." ScienceDaily. www.sciencedaily.com/releases/2007/02/070218135419.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com
Catching More Than Fish: Ugandan Town Crippled by AIDS

Catching More Than Fish: Ugandan Town Crippled by AIDS

AFP (Apr. 22, 2014) The village of Kasensero on the shores of Lake Victoria was where HIV-AIDS was first discovered in Uganda. Its transient population of fishermen and sex workers means the nationwide programme to combat the virus has had little impact. Duration: 02:30 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins